Bonded stationary phases for chromatography

Locke, David C.; Schmermund, John T.; Banner, Burton.

doi:10.1021/ac60309a019

Cited by 109 publications

(24 citation statements)

References 10 publications

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“…Among the most successful methods can be cited direct esterification, 3 sequential reactions with thionyl chloride and Grignard reagent 4 and the silanization method. [5][6][7] This latter eventually becoming the primary method for modifying the silica surface, being employed by all manufacturers of HPLC stationary phases.…”

Section: Chemically Bonded Stationary Phasesmentioning

confidence: 99%

State-of-the-art in immobilized polymer stationary phases for high-performance liquid chromatography

Faria¹,

Jardim²

2009

J. Braz. Chem. Soc.

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O aumento da estabilidade química e a redução da alta atividade de grupos residuais têm sido, nas últimas quatro décadas, os principais focos de pesquisas na preparação de fases estacionárias para cromatografia líquida de alta eficiência na modalidade de fase reversa (CLAE-FR). Novas e eficientes estratégias de modificação da superfície da sílica e a introdução de novos materiais como suportes cromatográficos têm minimizado estas limitações e possibilitado uma crescente popularização da CLAE-FR. Neste trabalho será apresentada uma visão geral do estado da arte de uma das estratégias de preparo de fases estacionárias que vem contornando tais limitações da CLAE-FR; as fases estacionárias baseadas na imobilização de polímeros orgânicos pré-sintetizados sobre partículas de sílica e sílica metalizada (zirconizada e titanizada). Uma consideração especial será dada ao desenvolvimento destas fases estacionárias ocorrido no Brasil nos últimos 15 anos.Increasing stability and reducing the high activity of residual groups from stationary phases have been the main focuses of research on the preparation of reversed-phase high-performance liquid chromatography (RP-HPLC) phases over the last four decades. New and more efficient strategies for modifying the silica surface as well as the introduction of new chromatographic supports have minimized these effects and have enabled the increasing popularization of RP-HPLC. In this paper, an overview will be given of the state-of-the-art in stationary phases for RP-HPLC based on immobilization of pre-synthesized organic polymers on both silica and metalized-silica supports. Special consideration is given to the development of HPLC stationary phases in Brazil in the past 15 years.

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Section: Chemically Bonded Stationary Phasesmentioning

confidence: 99%

State-of-the-art in immobilized polymer stationary phases for high-performance liquid chromatography

Faria¹,

Jardim²

2009

J. Braz. Chem. Soc.

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“…There was also IR evidence for SiH 2 groups. Partial conversion to Si-H has been observed on treatment of chlorinated silica with hydrogen at 975-1075 K [586]. Si-H groups are fixed to the surface in the condensation reaction with HSiCl 3 (vide infra).…”

Section: Modification Of Silica Surfacesmentioning

confidence: 99%

Nature and Estimation of Functional Groups on Solid Surfaces

1983

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“…Pioneer work on the modification of silica explored the covalent grafting onto surface silanols. Reactions with alcohols (Si-O-C) [6] and silanol chlorination and subsequent reactions with Grignard or organolithium reagents (Si-C) [7,8] or with amines (Si-N) [9] and condensation with alkoxy and chlorosilanes (Si-O-Si-C) [10,11] were first investigated. The relative stability of the Si-O-Si-C bond under different conditions and the non-demanding reaction conditions made that by the mid-1970s most of the work was being done with silanes [1][2][3].…”

Section: Surface Modification Of Silica Particlesmentioning

confidence: 99%

Organic Modification of Hydroxylated Nanoparticles: Silica, Sepiolite, and Polysaccharides

Tiemblo

García

Hoyos

et al. 2015

Handbook of Nanoparticles

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The incorporation of organic compounds onto the surface of nanoparticles (NPs) differs from the same reactions carried out on macroscopic surfaces in that the former are characterized by surfaces energies much higher than the latter. Consequently, surface stabilization mechanisms of NPs are very active, and among them NP self-aggregation is the first and most important. In NP surface modification, the ability of the experimental conditions to destroy self-aggregation will determine the extent to which the NP surface is modified and so, the modified NP nature. A second consequence of the high-surface free energy is the NP surface avidity to interact chemically or physically with other compounds: NPs readily adsorb water, gases, vapors, or other higher molecular weight substances, and in the particular case of hydroxylated NP, chemical reactivity is both high and rich. This chapter will deal with the surface modification of silica, sepiolite, and polysaccharides. Experimental strategies, resulting organo-NPs, their structure and properties, and frequent uses and applications of them will be reviewed.

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Bonded stationary phases for chromatography

Cited by 109 publications

References 10 publications

State-of-the-art in immobilized polymer stationary phases for high-performance liquid chromatography

State-of-the-art in immobilized polymer stationary phases for high-performance liquid chromatography

Nature and Estimation of Functional Groups on Solid Surfaces

Organic Modification of Hydroxylated Nanoparticles: Silica, Sepiolite, and Polysaccharides

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