Bone-derived CAD library for assembly of scaffolds in computer-aided tissue engineering

Bucklen, Brandon; Wettergreen, W.A.; Yüksel, Eser; Liebschner, Michael A. K.

doi:10.1080/17452750801911352

Cited by 50 publications

(23 citation statements)

References 49 publications

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“…In the second part of the study, microstructural models of three different scaffold architectures were used, based on those used in the literature (Bucklen et al, 2008;Luxner et al, 2005;Wettergreen et al, 2005). Unit cells for different architectures were generated for each scaffold, as shown in Figure 2.…”

Section: Model Applicationsmentioning

confidence: 99%

Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open-cell tissue engineering scaffolds

Shirazi

Ronan

Rochev

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Publication InformationShirazi, RN,Ronan, W,Rochev, Y,McHugh, P (2016) 'Modelling the degradation and elastic properties of poly (lacticco-glycolic AbstractScaffolding plays a critical rule in tissue engineering and an appropriate degradation rate and sufficient mechanical integrity are required during degradation and healing of tissue. This paper presents a computational investigation of the molecular weight degradation and the mechanical performance of poly(lactic-co-glycolic acid) (PLGA) films and tissue engineering scaffolds. A reactiondiffusion model which predicts the degradation behaviour is coupled with an entropy-based mechanical model which relates the Young's modulus and the molecular weight. The model parameters are determined based on experimental data for in-vitro degradation of a PLGA film. Microstructural models of three different scaffold architectures are used to investigate the degradation and mechanical behaviour of each scaffold. Although the architecture of the scaffold does not have a significant influence on the degradation rate, it determines the initial stiffness of the scaffold. It is revealed that the size of the scaffold strut controls the degradation rate and the mechanical collapse. A critical length scale due to competition between diffusion of degradation products and autocatalytic degradation is determined to be in the range 2-100 μm. Below this range, slower homogenous degradation occurs; however, for larger samples monomers are trapped inside the sample and faster autocatalytic degradation occurs.

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Section: Model Applicationsmentioning

confidence: 99%

Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open-cell tissue engineering scaffolds

Shirazi

Ronan

Rochev

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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“…Biomimetic scaffolds with similar microarchitectures, mechanical and biological properties as native tissue are of significant interest. Some groups established libraries for scaffold or unit cell designs which can be used to build scaffolds with certain mechanical and physical properties to satisfy the needs of the implantation site [2,[9][10][11][12]. Limitations of conventional fabrication techniques in producing the desired scaffold design can be overcome by Rapid Manufacturing (RM) techniques, which allow the manufacturing of complex 3D shapes with various pore designs from CAD files [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Fabrication, mechanical and in vivo performance of polycaprolactone/tricalcium phosphate composite scaffolds

et al. 2012

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In this paper, the use of the Selective Laser Sintering (SLS) process for the generation of bone tissue engineering scaffolds from PCL and PCL/TCP is explored. Different scaffold designs are generated and are assessed from the point of view of manufacturability, porosity and mechanical performance. Large scaffold specimens are generated, with a preferred design, and are assessed through an in vivo study in a critical size bone defect in the sheep tibia with subsequent microscopic, histological and mechanical evaluation. Further explorations are performed to generate scaffolds with increasing TCP contents.Scaffold fabrication from PCL and PCL/TCP mixtures with up to 50 mass-% TCP is shown to be possible. With increasing macroporosity the stiffness of the scaffolds is seen to drop, however, the stiffness can be increased by minor geometrical changes, such as the addition of a cage around the scaffold. In the animal study the selected scaffold for implantation did not perform as well as the TCP control in terms of new bone formation and the resulting mechanical performance of the defect area. A possible cause for this is presented.

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“…Because of the easy manufacturability and the open-pore structure of the lattice structure, it can realize the porous characteristics of the implant. As a result, many lattice structures have already been applied to the design of implant structures, and even a design scheme based on the lattice library has been formed [98,99]. Common lattice structures that are successfully applied in implants include polyhedral models based on CAD, models based on implicit surfaces, and models based on topological optimization, etc., as shown in Figure 7.…”

Section: Lattice Structure Designmentioning

confidence: 99%

Additive Manufacturing of Customized Metallic Orthopedic Implants: Materials, Structures, and Surface Modifications

Bai

Cheng

Chen

et al. 2019

Metals

132

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Metals have been used for orthopedic implants for a long time due to their excellent mechanical properties. With the rapid development of additive manufacturing (AM) technology, studying customized implants with complex microstructures for patients has become a trend of various bone defect repair. A superior customized implant should have good biocompatibility and mechanical properties matching the defect bone. To meet the performance requirements of implants, this paper introduces the biomedical metallic materials currently applied to orthopedic implants from the design to manufacture, elaborates the structure design and surface modification of the orthopedic implant. By selecting the appropriate implant material and processing method, optimizing the implant structure and modifying the surface can ensure the performance requirements of the implant. Finally, this paper discusses the future development trend of the orthopedic implant.

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Bone-derived CAD library for assembly of scaffolds in computer-aided tissue engineering

Cited by 50 publications

References 49 publications

Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open-cell tissue engineering scaffolds

Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open-cell tissue engineering scaffolds

Fabrication, mechanical and in vivo performance of polycaprolactone/tricalcium phosphate composite scaffolds

Additive Manufacturing of Customized Metallic Orthopedic Implants: Materials, Structures, and Surface Modifications

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