Bone fracture healing: perspectives according to molecular basis

Ruggieri, Iván Nadir Camal; Cícero, Andrés Mauricio; Issa, João Paulo Mardegan; Feldman, Sara

doi:10.1007/s00774-020-01168-0

Cited by 25 publications

(22 citation statements)

References 215 publications

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“…Therefore, we suggest that patients treated by the two fixation methods should avoid strenuous exercise after surgery as to prevent trabecular microfractures. According to Wolff’s law and the promoting factors of callus healing, the pressure of model A is slightly higher than that of model B, indicating the mechanical stimulation of model A is stronger than that of model B, which is very important in late fracture healing and callus plasticity ( 19 ). Rogge et al suggested that the more uniform the stress distribution in the fracture site is, the more beneficial to the fracture healing it will be ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

A finite element analysis of the supportive effect of a new type of rotary support plate on lateral tibial plateau fractures

Gao¹,

Yao²,

Geng³

et al. 2022

Ann Transl Med

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Background: Tibial plateau fractures (TPFs) are a challenging type of fracture in orthopedic traumatology.We previously designed a plate (Patent Number: CN201520195596.5) for posterolateral TPF combined with posterior lateral collapse.. In this study, finite element analysis was used to compare the biomechanical characteristics of two internal fixation methods for posterolateral TPF. We investigated the support effect of the new steel plate on lateral TPFs combined with posterior TPFs. Methods: Two models of complex TPF were established. Model A was fixed with the new type of plate, and model B was fixed without the plate. Three axial loads of 500, 1,000, and 1,500 N were applied using FEA on the two fracture models (A and B) to analyze the data.

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Section: Discussionmentioning

confidence: 99%

A finite element analysis of the supportive effect of a new type of rotary support plate on lateral tibial plateau fractures

Gao¹,

Yao²,

Geng³

et al. 2022

Ann Transl Med

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“…This activation leads to cytoskeletal changes in the osteocytes and remodeling of the ECM, circumstances that alter the bone tissue. The latest advances in intracellular signaling pathways, the osteocyte mechanotransmission system, and bone tissue engineering suggest promising experimental strategies, some of which could be employed in clinical trials [ 16 ].…”

Section: Integration Between the Cytoskeleton And The Main Moleculmentioning

confidence: 99%

A Review of Recent Developments in the Molecular Mechanisms of Bone Healing

Rodríguez-Merchán

2021

IJMS

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Between 5 and 10 percent of fractures do not heal, a condition known as nonunion. In clinical practice, stable fracture fixation associated with autologous iliac crest bone graft placement is the gold standard for treatment. However, some recalcitrant nonunions do not resolve satisfactorily with this technique. For these cases, biological alternatives are sought based on the molecular mechanisms of bone healing, whose most recent findings are reviewed in this article. The pro-osteogenic efficacy of morin (a pale yellow crystalline flavonoid pigment found in old fustic and osage orange trees) has recently been reported, and the combined use of bone morphogenetic protein-9 (BMP9) and leptin might improve fracture healing. Inhibition with methyl-piperidino-pyrazole of estrogen receptor alpha signaling delays bone regeneration. Smoking causes a chondrogenic disorder, aberrant activity of the skeleton’s stem and progenitor cells, and an intense initial inflammatory response. Smoking cessation 4 weeks before surgery is therefore highly recommended. The delay in fracture consolidation in diabetic animals is related to BMP6 deficiency (35 kDa). The combination of bioceramics and expanded autologous human mesenchymal stem cells from bone marrow is a new and encouraging alternative for treating recalcitrant nonunions.

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“…They act as bone sensors, altering bone formation in response to mechanical stimuli by causing fluid flow in the canaliculi space, which contains osteocytes. Lacunae osteocytes communicate with other osteocytes and bone cells via cadherin, α- or β-catenin, and Connexin proteins , by breaking bone, and osteoclast cells provide specific pathways for nerves and blood vessel transmission in regenerative activities. Osteoclast function is regulated by macrophage colony stimulating factor and RANKL …”

Section: Physiology and Pathophysiology Of Bone Tissuementioning

confidence: 99%

Criteria, Challenges, and Opportunities for Acellularized Allogeneic/Xenogeneic Bone Grafts in Bone Repairing

Sharifi

Kheradmandi

Salehi

et al. 2022

ACS Biomater. Sci. Eng.

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As bone grafts become more commonly needed by patients and as donors become scarcer, acellularized bone grafts (ABGs) are becoming more popular for restorative purposes. While autogeneic grafts are reliable as a gold standard, allogeneic and xenogeneic ABGs have been shown to be of particular interest due to the limited availability of autogeneic resources and reduced patient well-being in long-term surgeries. Because of the complete similarity of their structures with native bone, excellent mechanical properties, high biocompatibility, and similarities of biological behaviors (osteoinductive and osteoconductive) with local bones, successful outcomes of allogeneic and xenogeneic ABGs in both in vitro and in vivo research have raised hopes of repairing patients' bone injuries in clinical applications. However, clinical trials have been delayed due to a lack of standardized protocols pertaining to acellularization, cell seeding, maintenance, and diversity of ABG evaluation criteria. This study sought to uncover these factors by exploring the bone structures, ossification properties of ABGs, sources, benefits, and challenges of acellularization approaches (physical, chemical, and enzymatic), cell loading, and type of cells used and effects of each of the above items on the regenerative technologies. To gain a perspective on the repair and commercialization of products before implementing new research activities, this study describes the differences between ABGs created by various techniques and methods applied to them. With a comprehensive understanding of ABG behavior, future research focused on treating bone defects could provide a better way to combine the treatment approaches needed to treat bone defects.

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Bone fracture healing: perspectives according to molecular basis

Cited by 25 publications

References 215 publications

A finite element analysis of the supportive effect of a new type of rotary support plate on lateral tibial plateau fractures

A finite element analysis of the supportive effect of a new type of rotary support plate on lateral tibial plateau fractures

A Review of Recent Developments in the Molecular Mechanisms of Bone Healing

Criteria, Challenges, and Opportunities for Acellularized Allogeneic/Xenogeneic Bone Grafts in Bone Repairing

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