Bone Healing in a Rabbit Mandibular Defect Using Platelet-Rich Plasma

Evaluation of the role of autogenous bone-marrow–derived mesenchymal stem cell transplantation for the repair of mandibular bone defects in rabbits

“…This allowed us to examine in depth and to assess the early events during the process of bone regeneration as well as the relatively long-term follow-up of the regenerated bone within the experimental bone defects. This was in accordance with Miloro et al (Miloro et al, 2010), who criticized his evaluation periods of 1, 2, and 3 months for the study of bone healing in a rabbit mandibular defect using platelet-rich plasma, suggesting that perhaps some benefits from PRP would have been realized at the 2-week period, related to the early changes (Miloro et al, 2010). On the other hand, Busuttil Naudi suggested that evaluation periods longer than 3 months would be beneficial in long-term follow up of the surgical sites for studying bone bioengineering for mandibular reconstruction (Busuttil Naudi et al, 2012).…”

“…Review of the literature revealed multiple widely accepted experimental critical-sized defect designs in rabbits Rabie, 2002, 2003;Miloro et al, 2010;Busuttil Naudi et al, 2012). Rabie, 2002, 2003) conducted multiple studies involving mandibular bone defects repair in rabbits with a defect design of 10 mm  15 mm at the lower border without loss of mandibular continuity.…”

Comparison of Platelet-Rich Plasma and VEGF-Transfected Mesenchymal Stem Cells on Vascularization and Bone Formation in a Critical-Size Bone Defect

“…However, there is also a relevant number of studies reporting no or minimal effects of PRP on bone formation [Li et al, 2004;Roldan et al, 2004;Plachokova et al, 2007;Thor et al, 2007;Vasconcelos Gurgel et al, 2007;You et al, 2007;Miloro et al, 2010;Kazakos et al, 2011]. Regarding its clinical use in maxillofacial surgery, a recent metaanalysis indicated that there was sufficient evidence to support the use of PRP for bone formation on a sinus bone graft, whereas there was no significant effect on the implant survival and bone-to-implant contact [Bae et al, 2011].…”

Evaluation of Regenerative Processes in a Rat Model of Mandibular Condyle Defect using in vivo Micro X-Ray Computed Tomography

“…We observed cartilage-like tissue in the bone stumps, and this pseudocartilage was carrying out the ossification process in a sequential manner 1,7,8,13) . Thus far, in most of the studies that have observed reproduction of bone after creating a defect of the mandible, the defect has been created in the body of mandibible section [14][15][16][17][18][19][20] . Furthermore, several researchers attempted to transplant autogenous bone, allogeneic bone, decalcified powdered bone, and freeze-dried bone [14][15][16][17] .…”