Bone impairment assessed by HR-pQCT in juvenile-onset systemic lupus erythematosus

Paupitz, Juliane Aline; Lima, Glauce Leão; Alvarenga, Jackeline Couto; Oliveira, Ricardo Manoel de; Bonfá, Eloísa; Pereira, Rosa Maria Rodrigues

doi:10.1007/s00198-015-3461-y

Cited by 28 publications

(18 citation statements)

References 45 publications

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“…12 The precision of HR-pQCT showed coefficients of variation of 0.93%-1.41% at the distal radius and 0.25%-1.16% at the tibia for density measurements and 1.49%-7.59% at the distal radius and 0.78%-6.35% at the tibia for morphometric measurements, which are similar to the literature. 13 Segmentation of the cortex was obtained through an automatic segmentation algorithm. The common regions between the baseline and 1-year scan were identified and analyzed using a three-dimensional image registration framework using a baseline-indexed analysis.…”

Section: Measurement Of Bmd By Dxamentioning

confidence: 99%

“…The following biomechanical properties were analyzed using microfinite element analysis: stiffness (kilonewton per millimeter) and estimated failure load (newton). 13 Biochemical and Hormonal Determinations Blood samples were obtained at baseline and months 6 and 12 of the protocol. The samples were collected in a fasting state, and they were centrifuged in cryovials aliquots and stored at 280°C.…”

Section: Microfinite Element Analysismentioning

confidence: 99%

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A Randomized Trial of Zoledronic Acid to Prevent Bone Loss in the First Year after Kidney Transplantation

Marques¹,

Araujo

Graciolli

et al. 2019

JASN

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Background Bone and mineral disorders commonly affect kidney transplant (KTx) recipients and have been associated with a high risk of fracture. Bisphosphonates may prevent or treat bone loss in such patients, but there is concern that these drugs might induce adynamic bone disease (ABD). MethodsIn an open label, randomized trial to assess the safety and efficacy of zoledronate for preventing bone loss in the first year after kidney transplant, we randomized 34 patients before transplant to receive zoledronate or no treatment. We used dual-energy x-ray absorptiometry (DXA), high-resolution peripheral quantitative computed tomography (HR-pQCT), and bone biopsies to evaluate changes in bone in the 32 evaluable participants between the time of KTx and 12 months post-transplant.Results Both groups of patients experienced decreased bone turnover after KTx, but zoledronate itself did not affect this outcome. Unlike previous studies, DXA showed no post-transplant bone loss in either group; we instead observed an increase of bone mineral density in both lumbar spine and total hip sites, with a significant positive effect of zoledronate. However, bone biopsies showed post-transplant impairment of trabecular connectivity (and no benefit from zoledronate); HR-pQCT detected trabecular bone loss at the peripheral skeleton, which zoledronate partially attenuated.Conclusions Current immunosuppressive regimens do not contribute to post-transplant central skeleton trabecular bone loss, and zoledronate does not induce ABD. Because fractures in transplant recipients are most commonly peripheral fractures, clinicians should consider bisphosphonate use in patients at high fracture risk who have evidence of significantly low bone mass at these sites at the time of KTx.

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Section: Measurement Of Bmd By Dxamentioning

confidence: 99%

Section: Microfinite Element Analysismentioning

confidence: 99%

A Randomized Trial of Zoledronic Acid to Prevent Bone Loss in the First Year after Kidney Transplantation

Marques¹,

Araujo

Graciolli

et al. 2019

JASN

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“…The application of pQCT allowed enhancing the comprehension of age-related changes and sex differences in bone microarchitecture [ 95 ]. Over the past 10 years, many studies have been published about the use of pQCT in children and adolescent with chronic diseases potentially threatening bone health [ 96 ], such as cystic fibrosis [ 97 – 100 ], inflammatory bowel disease [ 101 – 105 ], juvenile idiopathic arthritis [ 106 – 109 ], cancer survivors [ 110 – 112 ], juvenile onset lupus erythematosus [ 109 , 113 – 115 ], hematologic disorders [ 116 – 119 ], mellitus diabetes [ 120 – 123 ], renal diseases [ 46 , 53 , 124 – 131 ], cerebral palsy [ 132 – 135 ], growth hormone deficiency [ 136 , 137 ], and genetic disorders and syndromes [ 138 – 149 ] (Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

“…JSLE patients present bone microstructure and strength deficits, particularly at the distal radius. Paupitz JA et al, 2016 [ 113 ] Longitudinal study 56 JSLE patients JSLE subjects present a reduced peak bone mass with high risk of osteoporosis in early adulthood. JSLE patients had significantly lower TrabBMD, SSI, but not muscleCSA and CBA values, while CortBMD and fatCSA were significantly increased.…”

Section: Introductionmentioning

confidence: 99%

Peripheral quantitative computed tomography (pQCT) for the assessment of bone strength in most of bone affecting conditions in developmental age: a review

Stagi

Cavalli

et al. 2016

Ital J Pediatr

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Peripheral quantitative computed tomography provides an automatical scan analysis of trabecular and cortical bone compartments, calculating not only their bone mineral density (BMD), but also bone geometrical parameters, such as marrow and cortical Cross-Sectional Area (CSA), Cortical Thickness (CoTh), both periosteal and endosteal circumference, as well as biomechanical parameters like Cross-Sectional Moment of Inertia (CSMI), a measure of bending, polar moment of inertia, indicating bone strength in torsion, and Strength Strain Index (SSI). Also CSA of muscle and fat can be extracted. Muscles, which are thought to stimulate bones to adapt their geometry and mineral content, are determinant to preserve or increase bone strength; thus, pQCT provides an evaluation of the functional ‘muscle-bone unit’, defined as BMC/muscle CSA ratio. This functional approach to bone densitometry can establish if bone strength is normally adapted to the muscle force, and if muscle force is adequate for body size, providing more detailed insights to targeted strategies for the prevention and treatment of bone fragility. The present paper offers an extensive review of technical features of pQCT and its possible clinical application in the diagnostic of bone status as well as in the monitoring of the skeleton’s health follow-up.

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“…A vBMD e a microarquitetura óssea foram avaliadas em uma sub amostra (Alvarenga et al, 2017). A HR-pQCT mostrou um coeficiente de variação de 0,93 a 1,41% no rádio distal e 0,25 a 1,16% na tíbia para medidas de densidade volumétrica e 1,49 a 7,59% no rádio distal e 0,78 a 6,35% na tíbia para parâmetros estruturais (Paupitz et al, 2016).…”

Section: Densidade Mineral óSsea Volumétrica E Microarquitetura óSseaunclassified

Efeitos da suplementação de creatina na massa óssea, função e força musculares e na composição corporal de mulheres pós-menopausadas com osteopenia: um estudo clínico, randomizado, controlado por placebo

Sales¹

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Bone impairment assessed by HR-pQCT in juvenile-onset systemic lupus erythematosus

Cited by 28 publications

References 45 publications

A Randomized Trial of Zoledronic Acid to Prevent Bone Loss in the First Year after Kidney Transplantation

A Randomized Trial of Zoledronic Acid to Prevent Bone Loss in the First Year after Kidney Transplantation

Peripheral quantitative computed tomography (pQCT) for the assessment of bone strength in most of bone affecting conditions in developmental age: a review

Efeitos da suplementação de creatina na massa óssea, função e força musculares e na composição corporal de mulheres pós-menopausadas com osteopenia: um estudo clínico, randomizado, controlado por placebo

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