Bone marrow–derived progenitor cells in pulmonary fibrosis

Hashimoto, Naozumi; Jin, Hong; Liu, Tianju; Chensue, Stephen W.; Phan, Sem H.

doi:10.1172/jci18847

Cited by 396 publications

(388 citation statements)

References 38 publications

(24 reference statements)

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“…It is likely that if these cells are mobilized at the wrong time and home to the wrong place (e.g., into areas of chronic inflammation), they may exert unwanted effects (Reya et al 2001;Virchow et al 1855). For example, BM-derived stem/progenitor cells have been implicated in the pathogenesis of lung fibrosis, ocular pterygia, and diabetic neuropathy (Hasegawa et al 2006;Hashimoto et al 2004;Song et al 2005).…”

Section: The Role Of Bm-derived Stem/progenitor Cells In Pathologymentioning

confidence: 99%

Bone-marrow-derived stem cells — our key to longevity?

et al. 2007

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Bone marrow (BM) was for many years primarily regarded as the source of hematopoietic stem cells. In this review we discuss current views of the BM stem cell compartment and present data showing that BM contains not only hematopoietic but also heterogeneous non-hematopoietic stem cells. It is likely that similar or overlapping populations of primitive non-hematopoietic stem cells in BM were detected by different investigators using different experimental strategies and hence were assigned different names (e.g., mesenchymal stem cells, multipotent adult progenitor cells, or marrow-isolated adult multilineage inducible cells). However, the search still continues for true pluripotent stem cells in adult BM, which would fulfill the required criteria (e.g. complementation of blastocyst development). Recently our group has identified in BM a population of very small embryonic-like stem cells (VSELs), which express several markers characteristic for pluripotent stem cells and are found during early embryogenesis in the epiblast of the cylinder-stage embryo.

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Section: The Role Of Bm-derived Stem/progenitor Cells In Pathologymentioning

confidence: 99%

Bone-marrow-derived stem cells — our key to longevity?

et al. 2007

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“…Circulating fi broblast-like cells (of presumably bone marrow origin [5,9]) can serve as sources of fi brocytes in lung tissue. Studying the effects of imHD, we focused our attention on the progenitor fi broblast cells.…”

Section: Resultsmentioning

confidence: 99%

Antifibrotic Effects of Immobilized Hyaluronidase in Repeated Bleomycin-Induced Lesions of the Alveolar Epithelium

Дыгай¹,

Скурихин²,

Ермакова³

et al. 2013

Bull Exp Biol Med

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Antifibrotic activity of testicular hyaluronidase, immobilized on polyethylenoxide and obtained by electron beam synthesis, was studied on the model of bleomycin injuries to the alveolar epithelium (irreversible pneumofibrosis) in C57Bl/6 mice and compared to the effect of testicular hyaluronidase. Intranasal therapy with immobilized and testicular hyaluronidases prevented the deposition of fibrotic mass in the parenchyma of "bleomycin" lungs. The effect of immobilized hyaluronidase was more pronounced than that of testicular hyaluronidase. The studied compounds were virtually inessential for infiltration of the alveolar interstitium and alveolar tracts by lymphocytes, macrophages, neutrophils, and plasma cells. Unchanged histoarchitectonics of bleomycin-damaged lungs in immobilized hyaluronidase therapy was due to suppression of the progenitor fibroblast cells (CD45(-)).

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“…Fibrocytes are bone marrow-derived mesenchymal progenitors, which co-express leukocyte (CD45, CD34, CD13) and mesenchymal markers (type I collagen, type I procollagen, fibronectin) (Chesney et al 1998;Bucala et al 1994;Abe et al 2001;Phillips et al 2004;Moore et al 2005;Hashimoto et al 2004;Mori et al 2005;Sakai et al 2006;Schmidt et al 2003;Aiba and Tagami 1997;Yang et al 2005). Moreover, fibrocytes are characterized by their ability to differentiate along multiple lineages, such as myofibroblasts, osteoblasts and adipocytes, giving rise to fully differentiated cells with distinct function (Choi et al 2010;Hong et al 2005;Phillips et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Nicotinic acetylcholine receptor alpha7 subunit is time-dependently expressed in distinct cell types during skin wound healing in mice

Wang

Liu

et al. 2011

Histochem Cell Biol

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Recent studies have shown that nicotinic acetylcholine receptor alpha7 subunit (nAChRα7) plays an important role in regulation of inflammation, angiogenesis and keratinocyte biology, but little is known about its expression after the skin is wounded. A preliminary study on time-dependent expression and distribution of nAChRα7 was performed by immunohistochemistry, Western blotting and RT-PCR during skin wound healing in mice. After a 1-cm-long incision was made in the skin of the central dorsum, mice were killed at intervals ranging from 6 h to 14 days post-injury. In uninjured skin controls, nAChRα7 positive staining was observed in epidermis, hair follicles, sebaceous glands, vessel endothelium and resident dermal fibroblastic cells. In wounded specimens, a small number of polymorphonuclear cells, a large number of mononuclear cells (MNCs) and fibroblastic cells (FBCs) showed positive reaction for nAChRα7 in the wound zones. Simultaneously, nAChRα7 immunoreactivity was evident in endothelial-like cells of regenerated vessels and neoepidermis. By morphometric analysis, an up-regulation of nAChRα7 expression was verified at the inflammatory phase after skin injury and reached a peak at the proliferative phase of wound healing. The expression tendency was further confirmed by Western blotting and RT-PCR assay. By immunofluorescent staining for co-localization, the nAChRα7-positive MNCs and FBCs in skin wounds were identified as macrophages, fibrocytes and myofibroblasts. A number of nAChRα7-positive myofibroblasts were also CD45 positive, indicating that they originated from differentiation of fibrocytes. The results demonstrate that nAChRα7 is time-dependently expressed in distinct cell types, which may be closely involved in inflammatory response and repair process during skin wound healing.

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Bone marrow–derived progenitor cells in pulmonary fibrosis

Cited by 396 publications

References 38 publications

Bone-marrow-derived stem cells — our key to longevity?

Bone-marrow-derived stem cells — our key to longevity?

Antifibrotic Effects of Immobilized Hyaluronidase in Repeated Bleomycin-Induced Lesions of the Alveolar Epithelium

Nicotinic acetylcholine receptor alpha7 subunit is time-dependently expressed in distinct cell types during skin wound healing in mice

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