Bone Marrow Stem Cell as a Potential Treatment for Diabetes

Li, Ming; Ikehara, Susumu

doi:10.1155/2013/329596

Cited by 14 publications

(10 citation statements)

References 61 publications

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“…On the other hand, the infusion of BMSCs suppressed helper T-cell development, thus attenuating immune responses and inflammatory damage [147]. Type I and type II diabetes have been the targets of BMSCs therapy [148][149][150][151]. There are several completed and in processing clinical trials registered in the database of U.S National Library of Medicine that used BMSCs in phase I to phase III clinical trials.…”

Section: Bmscs Involved In the Treatment Of Immune Disorder Diseasesmentioning

confidence: 99%

An Update on the Progress of Isolation, Culture, Storage, and Clinical Application of Human Bone Marrow Mesenchymal Stem/Stromal Cells

Chu

Phuong

Tien

et al. 2020

IJMS

141

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Bone marrow mesenchymal stem/stromal cells (BMSCs), which are known as multipotent cells, are widely used in the treatment of various diseases via their self-renewable, differentiation, and immunomodulatory properties. In-vitro and in-vivo studies have supported the understanding mechanisms, safety, and efficacy of BMSCs therapy in clinical applications. The number of clinical trials in phase I/II is accelerating; however, they are limited in the size of subjects, regulations, and standards for the preparation and transportation and administration of BMSCs, leading to inconsistency in the input and outcome of the therapy. Based on the International Society for Cellular Therapy guidelines, the characterization, isolation, cultivation, differentiation, and applications can be optimized and standardized, which are compliant with good manufacturing practice requirements to produce clinical-grade preparation of BMSCs. This review highlights and updates on the progress of production, as well as provides further challenges in the studies of BMSCs, for the approval of BMSCs widely in clinical application.

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Section: Bmscs Involved In the Treatment Of Immune Disorder Diseasesmentioning

confidence: 99%

An Update on the Progress of Isolation, Culture, Storage, and Clinical Application of Human Bone Marrow Mesenchymal Stem/Stromal Cells

Chu

Phuong

Tien

et al. 2020

IJMS

141

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“…The treatment of diabetes mellitus includes diet (Li Volti et al, 2011 ; Marrazzo et al, 2014 ), therapy with insulin and/or oral hypoglycemic agents and pancreas transplantation or pancreatic islets (Logdberg et al, 2003 ). However, because of the limited availability of donor organs, recent studies have focused on the possibility of using stem cells for the treatment of DM (Li and Ikehara, 2013 ).…”

Section: Diabetes and Related Complicationsmentioning

confidence: 99%

Therapeutic Efficacy of Stem Cells Transplantation in Diabetes: Role of Heme Oxygenase

Raffaele

Volti

Barbagallo

et al. 2016

Front. Cell Dev. Biol.

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The growing data obtained from in vivo studies and clinical trials demonstrated the benefit of adult stem cells transplantation in diabetes; although an important limit is represented by their survival after the transplant. To this regard, recent reports suggest that genetic manipulation of stem cells prior to transplantation can lead to enhanced survival and better engraftment. The following review proposes to stimulate interest in the role of heme oxygenase-1 over-expression on transplantation of stem cells in diabetes, focusing on the clinical potential of heme oxygenase protein and activity to restore tissue damage and/or to improve the immunomodulatory properties of transplanted stem cells.

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“…Extensive stellate cell-mediated fibrosis is a main characteristic of CP as well as pancreatic cancer ( 53 , 54 ). It was observed that bone marrow-derived stem cells could incorporate into the pancreas and differentiate to the exocrine compartment ( 55 ). This differentiation adopted various phenotypes depending on whether cells are recruited to an inflammatory or a carcinogenic pancreas.…”

Section: Chronic Pancreatitis (Cp) and Pancreatic Fibrosismentioning

confidence: 99%

Pancreas β cell regeneration and type 1 diabetes (Review)

Jian-hua

Yang

Chen

et al. 2014

Experimental and Therapeutic Medicine

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Diabetes mellitus, which may cause hyperglycemia and a number of complications, mostly results from a deficiency of β cell mass (type 1 diabetes) or a limitation of β cell function (type 2 diabetes). Currently, enhancing β cell regeneration and increasing cell proliferation have not only been described in experimental diabetes models, but have also been proven to improve outcomes for patients with diabetes. Therefore, understanding the mechanisms controlling the development and regeneration of β cells in the human pancreas may be helpful for the treatment of β cell-deficient disease. In this review, we first introduce the various cell types in the adult pancreas and thereby clarify their functions and origins. Then, the known mechanisms of β cell development and expansion in the normal human pancreas are described. The potential mechanisms of β cell regeneration, including β cell self-replication, neogenesis from non-β cell precursors and transdifferentiation from α cells, are discussed in the next part. Finally, the ability of the pancreas to regenerate mature β cells is explored in pathological conditions, including type 1 diabetes, chronic pancreatitis and persistent hyperinsulinemic hypoglycemia of infancy.

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Bone Marrow Stem Cell as a Potential Treatment for Diabetes

Cited by 14 publications

References 61 publications

An Update on the Progress of Isolation, Culture, Storage, and Clinical Application of Human Bone Marrow Mesenchymal Stem/Stromal Cells

An Update on the Progress of Isolation, Culture, Storage, and Clinical Application of Human Bone Marrow Mesenchymal Stem/Stromal Cells

Therapeutic Efficacy of Stem Cells Transplantation in Diabetes: Role of Heme Oxygenase

Pancreas β cell regeneration and type 1 diabetes (Review)

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