Bone mechanical properties and changes with osteoporosis

Osterhoff, Georg; Morgan, Elise F.; Shefelbine, Sandra J.; Karim, Lamya; McNamara, Laoise M.; Augat, Peter

doi:10.1016/s0020-1383(16)47003-8

Cited by 413 publications

(334 citation statements)

References 111 publications

(145 reference statements)

Supporting

Mentioning

303

Contrasting

Unclassified

Order By: Relevance

“…As it was reported in details in our previous papers, the weakening of the biomechanical properties of the femur due to the treatment with Cd results from the unfavourable impact of this heavy metal on the mineral status and organic matrix (formed mainly by collagen) of the bone [15][16][17][18]33,34]. Proper amount and structure of collagen fibers play an important role for bone formation and strength [29,30,35]. The results of the present study show that the low exposure to Cd (1 mg Cd/kg diet) inhibited collagen biosynthesis in the bone tissue already after 10 months.…”

Section: Discussionmentioning

confidence: 95%

“…Thus, it seems very important to recognize effective ways of prevention from health effects of exposure to Cd, including its impact on the skeleton. because the bone biomechanical properties are determined not only by the bone mineral status, but also by the bone matrix composed mainly of collagen [29,30], the concentration of procollagen I (PC I), as a marker of collagen biosynthesis, in the bone tissue was assayed.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Protective Effect of Chokeberry (<em>Aronia melanocarpa </em>L.) Extract Against Cadmium Impact on the Biomechanical Properties of the Femur: A Study in a Rat Model of Low and Moderate Lifetime Women Exposure to this Heavy Metal

Brzóska

Roszczenko

Rogalska

et al. 2017

Preprint

View full text Add to dashboard Cite

The hypothesis that consumption of Aronia melanocarpa berries (chokeberries) extract, recently reported by us to improve bone metabolism in female rats at low-level and moderate chronic exposure to cadmium (1 and 5 mg Cd/kg diet for up to 24 months), may increase the bone resistance to fracture was investigated. Biomechanical properties of the neck (bending test with vertical head loading) and diaphysis (three-point bending test) of the femur of rats administered 0.1% aqueous chokeberry extract (65.74% of polyphenols) or/and Cd in the diet (1 and 5 mg Cd/kg) for 3, 10, 17, and 24 months were evaluated. Moreover, procollagen I was assayed in the bone tissue. The low-level and moderate exposure to Cd decreased procollagen I concentration in the bone tissue and weakened biomechanical properties of the femoral neck and diaphysis. Chokeberry extract administration under the exposure to Cd improved the bone collagen biosynthesis and femur biomechanical properties. The results allow for the conclusion that consumption of chokeberry products under exposure to Cd may improve the bone biomechanical properties and protect from fracture. This study provides support for Aronia melanocarpa berries being a promising natural agent for the skeleton protection under low-level and moderate chronic exposure to Cd.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Protective Effect of Chokeberry (<em>Aronia melanocarpa </em>L.) Extract Against Cadmium Impact on the Biomechanical Properties of the Femur: A Study in a Rat Model of Low and Moderate Lifetime Women Exposure to this Heavy Metal

Brzóska

Roszczenko

Rogalska

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

“…This finding is expected since sound bone presents higher mineral quantity to attenuate micro‐CT X‐ray source when compared to a demineralized one . The increase in pores size is more evident in bone slab immersed for 30 days, and this time was chosen in order to simulate higher microstructure changes that can affect the bone resistance, a characteristic of the osteoporosis disease .…”

Section: Resultsmentioning

confidence: 99%

Assessment of simulated osteoporosis in alveolar bone using optical coherence tomography

Del-Valle

Lins

Ana

2019

Journal of Biophotonics

View full text Add to dashboard Cite

Steoporosis is a skeletal disorder that compromises bone resistance and its diagnosis is usually performed using dual energy X‐ray absorptiometry. Thus, the search for efficient diagnostic methods that do not involve the emission of ionizing radiation is necessary. This study proposed to use the Optical Coherence Tomography (OCT) to evaluate osteoporosis in alveolar bone. Osteoporosis lesions is simulated in vitro in porcine bones, and imaging is performed by OCT and micro‐computed tomography (micro‐CT). A developed algorithm is proposed to calculate the optical attenuation coefficient ( μ t), mean optical attenuation coefficient (μfalse¯t), integrated reflectivity (ΔR) and bone density ( BD). The μfalse¯t, ΔR and BD parameters shows a good correlation to micro‐CT parameters (bone volume/tissue volume and total porosity). The μ t and μfalse¯t methods are negatively impacted by non‐uniform intensities distribution in osteoporosis images. In conclusion, BD and ΔR analysis demonstrates to be potential techniques for diagnosis and monitoring of osteoporosis using OCT.

show abstract

“…Furthermore, collagen is not only a structural protein, but as an integrin ligand modulates the transduction of bone cell signals (Green, Schotland, Stauber, Kleeman, & Clemens, 1995). Therefore, disturbed structure or changes in the amount of collagen can contribute to the impairment of bone strength and increase the fracture risk (Burr, 2002;Garnero, 2015;Osterhoff et al, 2016; Saito & Marumo, 2015; Wang, Bank, TeKoppele, & Agrawal, 2001;…”

Section: Discussionmentioning

confidence: 99%

Beneficial impact of zinc supplementation on the collagen in the bone tissue of cadmium‐exposed rats

Andrulewicz-Botulińska

Brzóska

et al. 2018

J of Applied Toxicology

View full text Add to dashboard Cite

Cadmium (Cd) is a toxic metal that damages bone tissue by affecting its mineral and organic components. The organic matrix is mainly (90%) composed of collagen, which determines the biomechanical strength of bone. The aim of this study was to evaluate the effect of zinc (Zn) supplementation (30 or 60 mg l ) under moderate and relatively high exposure to Cd (5 and 50 mg l ) on collagen in the rat tibia proximal epiphysis and diaphysis (regions abundant in trabecular and cortical bone, respectively). Significant decrease in collagen type I biosynthesis was found in both regions of the tibia in Cd-treated rats, whereas the supplementation with Zn provided significant protection against this effect. Western blot confirmed the presence of the major type I collagen in the tibia epiphysis and diaphysis, but collagen type II was revealed only in the epiphysis. Acetic acid- and pepsin-soluble collagen concentration in the tibia epiphysis and diaphysis was significantly increased due to the exposure to Cd, whereas the supplementation with Zn protected, partially or totally, from these effects, depending on the used concentration. The supplementation with Zn also provided protection from unfavorable Cd impact on the maturation of the bone collagen, as the ratio of cross-links to monomers was higher compared to the Cd-treated group. This report confirms our previous findings on the preventive action of Zn against harmful effects of Cd on bone, but additionally, and to the best of our knowledge for the first time, explains the possible mechanism of the beneficial influence of this bioelement.

show abstract

Bone mechanical properties and changes with osteoporosis

Cited by 413 publications

References 111 publications

Protective Effect of Chokeberry (<em>Aronia melanocarpa </em>L.) Extract Against Cadmium Impact on the Biomechanical Properties of the Femur: A Study in a Rat Model of Low and Moderate Lifetime Women Exposure to this Heavy Metal

Protective Effect of Chokeberry (<em>Aronia melanocarpa </em>L.) Extract Against Cadmium Impact on the Biomechanical Properties of the Femur: A Study in a Rat Model of Low and Moderate Lifetime Women Exposure to this Heavy Metal

Assessment of simulated osteoporosis in alveolar bone using optical coherence tomography

Beneficial impact of zinc supplementation on the collagen in the bone tissue of cadmium‐exposed rats

Contact Info

Product

Resources

About