Bone metastases from thyroid carcinoma

McCormack, Kenneth R.

doi:10.1002/1097-0142(196602)19:2<181::aid-cncr2820190207>3.0.co;2-2

Cited by 72 publications

(49 citation statements)

References 12 publications

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“…In one of the largest available series of 45 cases of differentiated thyroid carcinoma who had bone metastasis at presentation, sternum was the most frequent site. 1 Metastasis in the bone is the third leading site for metastasis after lung and liver; about 15% of all carcinoma clinically manifest bone metastasis. 3 The majority of the bone metastasis are caused by cancer of the breast, lung, followed by thyroid as an intermediate group.…”

Section: Discussionsupporting

confidence: 70%

“…Differentiated thyroid cancer presenting with osseous metastases is very rare as it is reported in 3-12% cases only. 1,2 Out of the two differentiated thyroid cancers, higher prevalence of bone metastasis occurs in follicular (15.2%) than in papillary carcinoma (0.6%). 2,3 Although rare, the common sites of osseous metastases are sternum, vertebrae, pelvis, and ribs, while metastases to appendicular skeleton is the rarest.…”

Section: Introductionmentioning

confidence: 99%

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Unusual bone metastasis from follicular carcinoma thyroid: presenting as a primary bone malignancy

Varshney

Pant

2014

Int J Cancer Ther Oncol

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Osseous metastasis in patients of thyroid carcinoma is not very common, and appendicular skeleton is very rare. Bone metastasis represents a complication, especially of follicular thyroid carcinoma and severely reduces the quality of life causing pain, and fractures. Diagnosis is typically done by correlating clinical suspicion with imaging. Occult clinical presentations usually delay the detection and management of patients with bone metastasis from thyroid carcinoma. There is limited information about the clinical presentations and prognosis of patients with follicular thyroid carcinoma with bone metastasis. We hereby present a case report of right arm swelling diagnosed as metastatic carcinoma having metastasis from thyroid primary.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Unusual bone metastasis from follicular carcinoma thyroid: presenting as a primary bone malignancy

Varshney

Pant

2014

Int J Cancer Ther Oncol

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“…2,5) Various reports describe 3 or 4 years of treatment and follow up for these cases. 2,3) These tumors are rare, difficult to define histologically, and may often mimic other bone pathologies, so critical clinical diagnosis and aggressive therapy are required.…”

Section: Akdemir Et Almentioning

confidence: 99%

“…The most common forms are pulmonary and breast cancer metastases and prostate carcinomas. 2,6) Bone metastasis of thyroid carcinoma is the second most common form of metastasis following pulmonary metastasis. [1][2][3] However, metastases in the skull associated with carcinoma of the thyroid are rare, accounting for only 2.5% to 5.8% of cases.…”

Section: Introductionmentioning

confidence: 99%

“…2,6) Bone metastasis of thyroid carcinoma is the second most common form of metastasis following pulmonary metastasis. [1][2][3] However, metastases in the skull associated with carcinoma of the thyroid are rare, accounting for only 2.5% to 5.8% of cases. Solid masses causing lytic lesions in the cranium are suggestive of metastasis and present as various radiological findings with osteoblastic activity.…”

Section: Introductionmentioning

confidence: 99%

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Skull Metastasis From Thyroid Follicular Carcinoma With Difficult Diagnosis of the Primary Lesion-Case Report-

Akdemir

Erol

Akpolat

et al. 2005

Neurol. Med. Chir.(Tokyo)

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A 57-year-old male patient presented with an immobile ellipsoid mass of 6-cm diameter in the right occipitoparietal region. Cranial computed tomography showed the mass with dense contrast enhancement causing bone destruction. After embolization of the mass, total resection was performed. Histological examination showed the mass had a capsule, with no invasion of the dura mater or dermis, and the follicles of various sizes covered with mono-lined thyrocytes were full of colloid. Immunohistochemical examination showed positive staining for thyroglobulin. Postoperatively, levels of thyroid hormones were normal, and thyroid ultrasonography and technetium-99m scintigraphy showed no abnormalities. Fine needle aspiration biopsy performed at various locations of the thyroid gland revealed no atypical thyroid cells. Whole body technetium-99m scintigraphy found no abnormal bone involvement. The histological evidence was suggestive of follicular carcinoma metastasis. Surgical treatment was planned for the thyroid gland, but the patient did not consent. Two years later, the patient presented with the pain and sensitivity in the sacrum, the right iliac wing, and the right caput femoris. Computed tomography revealed lytic lesions in these areas. Bone metastases were identified. Whole body scintigraphy showed increased activity in these regions, but the cranium and all other tissues were normal. The patient underwent total thyroidectomy under a diagnosis of follicular carcinoma. The present case of a lytic skull lesion associated with normal thyroid tissue on admission but finally treated as follicular thyroid cancer emphasizes the difficulty in histological discrimination of follicular carcinoma from normal thyroid tissue.

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Skull Metastases From Follicular Thyroid Carcinoma

Kearns¹,

Robinson²,

Wright³

et al. 1988

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\Distant metastatic disease from thyroid carcinoma is becoming a rare problem. Physicians and the public are increasingly aware of minimally invasive methods of early diagnosis of thyroid malignancy, such as fine-needle aspiration with cytologic examination. Total thyroidectomy itself has become less associated with morbidity than it once was. We describe three patients with follicular thyroid carcinoma metastatic to the skull who were seen recently. Two of these patients had masses neglected for 20 and 50 years, respectively. The management of this disease entity is discussed.(Arch Otolaryngol Head Neck Surg

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Bone metastases from thyroid carcinoma

Cited by 72 publications

References 12 publications

Unusual bone metastasis from follicular carcinoma thyroid: presenting as a primary bone malignancy

Unusual bone metastasis from follicular carcinoma thyroid: presenting as a primary bone malignancy

Skull Metastasis From Thyroid Follicular Carcinoma With Difficult Diagnosis of the Primary Lesion-Case Report-

Skull Metastases From Follicular Thyroid Carcinoma

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