Bone Mineral Density in Patients With Chronic Obstructive Pulmonary Disease Who Are Candidates for Lung Transplant

Vaquero-Barrios, J.M.; Larriva, M.S. Arenas-de; Redel-Montero, Javier; Bujalance-Cabrera, Carlos; Santos-Luna, Francisco; Moreno, Paula; Espinosa-Jiménez, D.

doi:10.1016/j.transproceed.2010.07.069

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…Also a study by Jorgensen NR, et al, said that incidence of osteoporosis is higher in women than in men, and it is to be expected that women with COPD would be even more susceptible to develop osteoporosis than women with normal lung function. [11) In [12] Also, these results were in agreement with the results of the cross sectional study carried by Jorgensen et al who found that, BMD had direct relation with FEV1% in COPD patients who had osteoporosis. [5] Also a study by Sin et al, revealed that risk of osteopenia increases by 30% in moderate COPD and by 70% in severe COPD more than normal personnel, and the risk of osteoporosis increases by 2.1 fold in moderate COPD and by 2.8 fold in severe COPD more than normal personnel.…”

Section: Discussionsupporting

confidence: 87%

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Occurrence of Osteoporosis in COPD Patients- A Comparative Study with Age & Sex Matched Control

Mamnoon¹

2017

JMSCR

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Introduction: Chronic Obstructive Pulmonary Disease (COPD) has been found to be associated with a variety of systemic manifestations and reduced bone mineral density being one of them. Due to scarcity of available Indian data, there is a need to evaluate the problem of osteoporosis in Indian population. Methods: This prospective observational study was conducted with the objectives of studying the occurrence of osteoporosis in COPD patients as compared to age-sex matched controls and to assess the co-relation of osteoporosis with the severity of COPD.60 COPD (35 males & 25 females) cases, age & sex matched 60 control were classified. GOLD criteria 2013 was used to grade severity. Detailed clinical history & examination, blood investigations, spirometry & DEXA for bone density measurement was done. Results: Among 60COPD patients, 37 had osteoporosis (40.5% females, 59.45% males), 22 had osteopenia. As apposed, only 11.6%&68.3% control group patients had osteoporosis & osteopenia respectively. We found Lumbar spine osteoporosis to be more common. 22.2%moderate, 96% severe & 85.7%very severe COPD patients had osteoporosis, which was statistically significant. Conclusion: COPD patients are at a greater risk for osteoporosis when compared to age-sex matched control group patients. This risk increased with the severity of COPD.

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Section: Discussionsupporting

confidence: 87%

“…Samples were taken by using universal sample technique. The above tables (10,11,12) show, that percentage of osteoporosis & osteopenia increases as the severity of COPD increases. This association was statistically significant only for Whole Body bone densitometry (p-value 0.005).…”

Section: Healthy Controls With Osteoporosis Basedmentioning

confidence: 94%

Occurrence of Osteoporosis in COPD Patients- A Comparative Study with Age & Sex Matched Control

Mamnoon¹

2017

JMSCR

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“…Therefore, much of the burden of COPD is preventable 48 . COPD is associated with multiple comorbidities, including heart disease, 49 cancer, 50 depression, 51 and decreased bone mineral density, 52 among others ( Table 1 ). COPD encompasses both chronic bronchitis and emphysema.…”

Section: Copd: Clinical Opportunities With Second‐generation Pde4 Inhmentioning

confidence: 99%

PDE4: A Novel Target in the Treatment of Chronic Obstructive Pulmonary Disease

Michalski

Golden

Ikari

et al. 2011

Clin Pharmacol Ther

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Phosphodiesterases (PDEs) are important modulators of inflammation and wound healing. In this capacity, specific targeting of PDEs for the treatment of many diseases, including chronic obstructive pulmonary disease (COPD), has been investigated. Currently, treatment of COPD is suboptimal. PDE4 modulates the inflammatory response of the lung, and inhibition of PDE4 may be a novel, COPD‐specific approach toward more effective treatment strategies. This review describes the state of PDE4‐inhibitor therapy for use in COPD treatment. Clinical Pharmacology & Therapeutics (2012); 91 1, 134–142. doi:

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Pretransplant Considerations in Patients with Obstructive Lung Disease: COPD, Lymphangioleiomyomatosis, Cystic Fibrosis, and Non-CF Bronchiectasis

Ajani

Kotloff

2018

Lung Transplantation

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Bone Mineral Density in Patients With Chronic Obstructive Pulmonary Disease Who Are Candidates for Lung Transplant

Cited by 8 publications

References 10 publications

Occurrence of Osteoporosis in COPD Patients- A Comparative Study with Age & Sex Matched Control

Occurrence of Osteoporosis in COPD Patients- A Comparative Study with Age & Sex Matched Control

PDE4: A Novel Target in the Treatment of Chronic Obstructive Pulmonary Disease

Pretransplant Considerations in Patients with Obstructive Lung Disease: COPD, Lymphangioleiomyomatosis, Cystic Fibrosis, and Non-CF Bronchiectasis

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