Bone mineral density is increased after a 16-week resistance training intervention in elderly women with decreased muscle strength

Huovinen, Ville; Ivaska, Kaisa K.; Kiviranta, Riku; Bucci, Marco; Lipponen, Heta; Sandboge, Samuel; Raiko, Juho; Eriksson, Johan G.; Parkkola, Riitta; Iozzo, Patricia; Nuutila, Pirjo

doi:10.1530/eje-16-0521

Cited by 33 publications

(28 citation statements)

References 42 publications

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“…Several studies have investigated the effect of exercise on bone turnover markers in serum in non‐OA individuals, however, with varying results . In agreement with our study, resistance exercise combined with or without impact loading was without effect on CTX and PINP, However, soccer training increased PINP and CTX levels in non‐OA individuals suggesting that the type of exercise is relevant for the effect on bone turnover. The lack of effect of exercise on PINP and CTX in our study could therefore be due to the type or duration of exercise but could also be the result of altered bone turnover in OA patients.…”

Section: Discussionsupporting

confidence: 88%

The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

et al. 2019

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Exercise is recommended as first‐line treatment to reduce pain and improve physical function in patients with hip osteoarthritis, but the mechanism behind the effect remains unknown. Blood and urine were collected at baseline and after 4 months of exercise from 60+‐year‐old persons (n = 39) with hip osteoarthritis included in a randomized controlled trial comparing the effects of strength training (ST), Nordic Walking (NW), and unsupervised home‐based exercise (control). We measured biomarkers of bone (N‐terminal propeptide of type I collagen, C‐telopeptide of type I collagen, sclerostin, receptor activator of nuclear factor kappa‐B ligand, and osteoprotegerin) and cartilage (C‐telopeptide of type II collagen (CTX‐II), cartilage oligomeric matrix protein, and N‐terminal propeptide of type III collagen). Sclerostin levels decreased independent of the type of training. There was significant interaction between type of training and change in CTX‐II level. When combining the supervised groups (NW and ST), both CTX‐II and sclerostin level were decreased in the supervised training group, while CTX‐II and sclerostin were unchanged in the control group. In conclusion, CTX‐II and sclerostin level were reduced by 4 months of supervised training, suggesting that certain types of exercise affect cartilage and bone, potentially contributing to beneficial effects of exercise in patients.

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Section: Discussionsupporting

confidence: 88%

The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

et al. 2019

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“…Thus, the authors of above study obtained convergent results to ours. Huovinen et al [30] analyzed the effects of resistance training on the elderly patients with reduced muscle strength. After 16 weeks of intervention a significant increase in sclerostin and OC was noted, unlike the other markers (CTX and PINP).…”

Section: Prace Oryginalnementioning

confidence: 99%

Effects of physical activity on sclerostin concentrations

Janik

Stuss

Michalska-Kasiczak

et al. 2015

Endokrynologia Polska

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“…These studies encompassed a varied population as to age, sex and training protocols, using only resistance exercises, but with different loading intensities, with the exception of the Petersen et al 24 study, which included exercise for cardiovascular endurance on a bicycle. For Petersen et al 24 , the use of low loads (20% 1-RM) associated to the high number of repetitions showed similar effectiveness to other studies that employed intensity between 50-95% 1-RM 21,32 . Additionally, the study of Almstedt et al 32 which analyzed the alterations by sex, indicated that among men the effects were more pronounced.…”

Section: Effects Of Resistance Training On Body Composition Muscle Smentioning

confidence: 68%

“…The studies highlighted in Boards 1 and 2 provide updated results corroborating the effects of RT on bone remodeling. Studies that showed a greater effect of RT on BMC/BMD reported changes between 6 and 8% 21,22,32 . These studies encompassed a varied population as to age, sex and training protocols, using only resistance exercises, but with different loading intensities, with the exception of the Petersen et al 24 study, which included exercise for cardiovascular endurance on a bicycle.…”

Section: Effects Of Resistance Training On Body Composition Muscle Smentioning

confidence: 99%

“…Even, it cannot be state that the effects of RT on BMC/BMD would vary according to the type of exercises and amount of muscle mass engaged in exercise, since only the study of Huovinen et al 21 used multi-joint exercises exclusively. Meanwhile, the studies of Petersen et al 24 and Almstedt et al 32 included only small muscle exercises in the protocol, as well as exercises for pelvic region.…”

Section: Effects Of Resistance Training On Body Composition Muscle Smentioning

confidence: 99%

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Bone Health, Muscle Strength and Lean Mass: Relationships and Exercise Recommendations

Pimenta

Massini

Santos

et al. 2019

Rev Bras Med Esporte

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Although muscle strength, lean mass and bone mineral content/density (BMC/BMD) are consistently reported as major outcomes of resistance training (RT), there is still no agreement on the RT regimen that is capable of achieving this result in men and women of different ages. This study describes the effects of RT on muscle strength, lean mass and bone mineralization, highlighting the relationships between them and analyzing the effectiveness of the RT protocol. Information searches were conducted in open access online academic libraries, using the BMC/BMD indices combined with muscle strength, body composition, and resistance exercises. The results showed changes in BMC/BMD in 72% of the studies published in the last decade. Among these, 77% recommended loads ≥ 80% 1-RM, 61% involved older individuals (> 60 years) and 61% had planning protocols of between 3 and 5 months (~12-20 weeks). The results also highlight muscle strength as a promising index of variations in BMC/BMD, with a moderate to high level of association (r2>0.5), which are specific for men and women in relation to the body region with best responsiveness. Among the studies published in last decade, about 61% had protocols involving only RT, and of these, 82% observed combined changes in BMC/BMD, body composition and muscle strength. This review therefore concludes that RT is important for improving muscle strength, increasing lean mass (whole-body and regional) and preventing risk factors that could impair the mineral integrity of the bone tissue, in individuals of all ages and sexes. Level of Evidence I; Systematic review of Level I RCTs (and study results were homogenous).

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Bone mineral density is increased after a 16-week resistance training intervention in elderly women with decreased muscle strength

Abstract: Our findings suggest an important role of continuous supervised resistance training for the prevention of osteoporotic fractures in elderly women with decreased muscle strength.

Cited by 33 publications

References 42 publications

The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

Effects of physical activity on sclerostin concentrations

Bone Health, Muscle Strength and Lean Mass: Relationships and Exercise Recommendations

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