Effects of physical activity on sclerostin concentrations

Janik, Małgorzata; Stuss, Michał; Michalska-Kasiczak, Marta; Jegier, Anna; Sewerynek, Ewa

doi:10.5603/ep.a2018.0008

Cited by 29 publications

(35 citation statements)

References 37 publications

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“…Another factor influencing sclerostin levels and its association with anthropometric parameters is physical activity. Some studies showed that regular physical activity significantly reduces circulating sclerostin levels in postmenopausal women [24,25]. However, due to the lack of objective assessment of physical activity in our study, we did not confirm its impact on the obtained results.…”

Section: Discussioncontrasting

confidence: 75%

Circulating sclerostin levels in relation to nutritional status, sex hormones and selected bone turnover biochemical markers levels in peri- and postmenopausal women

et al. 2019

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Objectives:Hormonal changes during the peri-and postmenopausal age, especially decreasing estradiol levels as the result of the expired ovarian function, are an established link of the pathogenesis of postmenopausal osteoporosis. The objective of the study was to examine the association between the circulating sclerostin levels and nutritional status, sex hormones and selected bone markers turnover levels in peri-and postmenopausal women. Material and methods:The study enrolled 84 stable-body mass women (31 perimenopausal and 54 postmenopausal). Anthropometric measurements and serum estrone, testosterone, androstenedione, DHEA-S, osteocalcin, β-CTx, 25-OH-Vitamin D and sclerostin levels were obtained.Results: There were not any differences between body mass, BMI, body fat and waist circumference between the study groups. The serum androstenedione and DHEA-S levels were similar in both study groups. However, estrone and total testosterone levels were observed to be notably higher in the perimenopausal group, unlike in the postmenopausal group (124.1 pg/mL vs. 98.3 pg/mL, p < 0.01 and 0.3 pg/mL vs. 0.22 pg/mL, p < 0.01, respectively). Higher plasma osteocalcin and β-CTx levels were shown in the postmenopausal rather than in the perimenopausal group (19.8 ng/mL vs. 16.8 ng/mL, p < 0.001 and 0.35 ng/mL vs. 0.29 ng/mL, p < 0.05, respectively). Plasma sclerostin and 25-OH-Vitamin D levels were similar. There was not any correlation between plasma sclerostin levels and the other studied parameters. In the multivariate regression analyses, sclerostin levels were proportional to the androstenedione ones (b = 0.06; p < 0.05) but inversely related to the log10(testosterone) levels (b = -0.18; p < 0.05). Conclusions:Circulating sclerostin levels are similar in peri-and postmenopausal women and are related to the androstenedione and testosterone levels regardless of the nutritional status.

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Section: Discussioncontrasting

confidence: 75%

Circulating sclerostin levels in relation to nutritional status, sex hormones and selected bone turnover biochemical markers levels in peri- and postmenopausal women

et al. 2019

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“…Hinton et al found that 1 year of exercise (jump 3 times weekly or resistance training twice weekly) in healthy men with low bone mass reduced sclerostin levels with 4.5%‐9.5% compared to baseline. Similar results were seen in osteopenic women after 12 weeks of exercise . These findings are comparable to the effect seen in our study, where ST and NW reduced sclerostin level by 5%‐8%, suggesting that the response of sclerostin to exercise training is similar in patients with OA compared to other groups of patients or healthy individuals.…”

Section: Discussionsupporting

confidence: 90%

The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

et al. 2019

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Exercise is recommended as first‐line treatment to reduce pain and improve physical function in patients with hip osteoarthritis, but the mechanism behind the effect remains unknown. Blood and urine were collected at baseline and after 4 months of exercise from 60+‐year‐old persons (n = 39) with hip osteoarthritis included in a randomized controlled trial comparing the effects of strength training (ST), Nordic Walking (NW), and unsupervised home‐based exercise (control). We measured biomarkers of bone (N‐terminal propeptide of type I collagen, C‐telopeptide of type I collagen, sclerostin, receptor activator of nuclear factor kappa‐B ligand, and osteoprotegerin) and cartilage (C‐telopeptide of type II collagen (CTX‐II), cartilage oligomeric matrix protein, and N‐terminal propeptide of type III collagen). Sclerostin levels decreased independent of the type of training. There was significant interaction between type of training and change in CTX‐II level. When combining the supervised groups (NW and ST), both CTX‐II and sclerostin level were decreased in the supervised training group, while CTX‐II and sclerostin were unchanged in the control group. In conclusion, CTX‐II and sclerostin level were reduced by 4 months of supervised training, suggesting that certain types of exercise affect cartilage and bone, potentially contributing to beneficial effects of exercise in patients.

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“…Higher serum sclerostin concentrations have been found in patients with prevalent cardiovascular disease and were independently associated with cardiovascular mortality (Novo‐Rodríguez et al, 2018). When considering the impact of exercise on the sclerostin level, it has been demonstrated that a single bout of exercise leads to acute increase in blood sclerostin levels (Kouvelioti et al, 2019; Pickering et al, 2017) but several weeks of interval training (Janik, Stuss, Michalska‐Kasiczak, Jegier, & Sewerynek, 2018) decrease blood sclerostin level, which suggests positive, antiosteoporotic effects of a long‐term exercise. However, the impact of regular physical activity on the sclerostin concentration in heart failure condition still remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Impact of long‐lasting spontaneous physical activity on bone morphogenetic protein 4 in the heart and tibia in murine model of heart failure

Majerczak¹,

Filipowska

Tylko

et al. 2020

Physiol Rep

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Bone morphogenetic protein 4 (BMP4) plays an important role in bone remodeling and in heart failure pathogenesis. The aim of this study was to evaluate the effect of spontaneous physical activity on the expression of BMP4 in the heart and tibia of the transgenic (Tgαq*44) mice, representing a model of chronic heart failure. Tgαq*44 and wild-type FVB mice (WT) were randomly assigned either to sedentary or to trained groups undergoing 8 weeks of spontaneous wheel running. The BMP4 protein expression in heart and tibiae was evaluated using Western immunoblotting and the phosphorus and calcium in the tibiae was assessed using the X-ray microanalysis.BMP4 content in the hearts of the Tgαq*44-sedentary mice was by ~490% higher than in the WT-sedentary mice, whereas in tibiae the BMP4 content of the Tgαq*44sedentary mice was similar to that in the WT-sedentary animals. Tgαq*44 mice revealed by ~28% poorer spontaneous physical activity than the WT mice. No effect of performed physical activity on the BMP4 content in the hearts of either in the Tgαq*44 or WT mice was observed. However, 8-week spontaneous wheel running resulted in a decrease in the BMP4 expression in tibiae (by ~43%) in the group of Tgαq*44 mice only, with no changes in their bone phosphorus and calcium contents.We have concluded that prolonged period of spontaneous physical exercise does not increase the risk of the progression of the BMP4-mediated pathological cardiac hypertrophy and does not affect bone mineral status in the chronic heart failure mice. K E Y W O R D SBMP4, heart failure, physical activity

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Effects of physical activity on sclerostin concentrations

Abstract: The obtained results emphasise the role of physical training as an effective stimulation method of bone formation processes in women with osteopenia. Sclerostin can be a marker of physical activity. < /p > < p >.

Cited by 29 publications

References 37 publications

Circulating sclerostin levels in relation to nutritional status, sex hormones and selected bone turnover biochemical markers levels in peri- and postmenopausal women

Circulating sclerostin levels in relation to nutritional status, sex hormones and selected bone turnover biochemical markers levels in peri- and postmenopausal women

The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

Impact of long‐lasting spontaneous physical activity on bone morphogenetic protein 4 in the heart and tibia in murine model of heart failure

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