Bone Quality: A Reality for the Process of Osseointegration

Sakka, Salah; Coulthard, Paul

doi:10.1097/id.0b013e3181bb840d

Cited by 60 publications

(41 citation statements)

References 32 publications

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“…12 Quantification of trabecular structure can be of value when determining the risk of osteoporotic bone 13,14 as well as in the stability of tooth implants. 15,16 There are, to our knowledge, only a few articles describing the possibility of using CBCT to image trabecular microarchitecture where these measurements have been verified using micro-CT (mCT), [17][18][19][20] which can be regarded as a gold standard. 21 The aim of this in vitro study was to evaluate how different imaging settings in CBCT may affect the accuracy in quantifying trabecular bone structure by comparing the results to those of a gold standard, mCT.…”

mentioning

confidence: 99%

Trabecular bone histomorphometric measurements and contrast-to-noise ratio in CBCT

Klintström

Smedby²,

Klintström³

et al. 2014

Dentomaxillofacial Radiology

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Objectives: The aim of this study was to evaluate how imaging parameters at clinical dental CBCT affect the accuracy in quantifying trabecular bone structures, contrast-to-noise ratio (CNR) and radiation dose. Methods: 15 radius samples were examined using CBCT (Accuitomo FPD; J. Morita Mfg., Kyoto, Japan). Nine imaging protocols were used, differing in current, voltage, rotation degree, voxel size, imaging area and rotation time. Radiation doses were measured using a kerma area product-meter. After segmentation, six bone structure parameters and CNRs were quantified. Micro-CT (mCT) images with an isotropic resolution of 20 mm were used as a gold standard. Results: Structure parameters obtained by CBCT were strongly correlated to those by mCT, with correlation coefficients .0.90 for all studied parameters. Bone volume and trabecular thickness were not affected by changes in imaging parameters. Increased tube current from 5 to 8 mA, decreased isotropic voxel size from 125 to 80 mm and decreased rotation angle from 360°to 180°affected correlations for trabecular termini negatively. Decreasing rotation degree also weakened correlations for trabecular separation and trabecular number at 80 mm voxel size. Changes in the rotation degree and tube current affected CNR significantly. The radiation dose varied between 269 and 1153 mGy cm 2 . Conclusions: Trabecular bone structure can be accurately quantified by clinical dental CBCT in vitro, and the obtained structure parameters are strongly related to those obtained by mCT. A fair CNR and strong correlations can be obtained with a low radiation dose, indicating the possibility for monitoring trabecular bone structure also in vivo.

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mentioning

confidence: 99%

Trabecular bone histomorphometric measurements and contrast-to-noise ratio in CBCT

Klintström

Smedby²,

Klintström³

et al. 2014

Dentomaxillofacial Radiology

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“…Therefore, the neovascularization goes together with new-formed bone formation (Raines et al, 2010;Santos and Reis, 2010) and clinically, this point is of particular interest to enhance the primary and longterm fixation of implants (Davies, 2003;Broos and Sermon, 2004;Sakka and Coulthard, 2009). …”

Section: Discussionmentioning

confidence: 99%

Wave front migration of endothelial cells in a bone-implant interface

Khalil

Lorthois

Marcoux

et al. 2011

Journal of Biomechanics

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OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. This is an author-deposited version published in : http://oatao.univ-toulouse.fr/ Eprints ID : 18179 a b s t r a c tThe neo-vascularization of the host site is crucial for the primary fixation and the long-term stability of the bone-implant interface. Our aim was to investigate the progression of endothelial cell population in the first weeks of healing. We proposed a theoretical reactive model to study the role of initial conditions, random motility, haptotaxis and chemotaxis in interactions with fibronectin factors and transforming angiogenic factors. The application of governing equations concerned a canine experimental implant and numerical experiments based upon statistical designs of experiments supported the discussion.We found that chemotaxis due to transforming angiogenic factors was attracting endothelial cells present into the host bone. Haptotaxis conditioned by fibronectin factors favored cells adhesion to the host bone. The combination of diffusive and reactive effects nourished the wave front migration of endothelial cells from the host bone towards the implant. Angiogenesis goes together with new-formed bone formation in clinics, so the similarity of distribution patterns of mineralized tissue observed invivo and the spatio-temporal concentration of endothelial cells predicted by the model, tended to support the reliability of our theoretical approach.

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“…Cortical bone helps to attain primary implant stability, but the role of cancellous bone is also remarkable. This is because cancellous bone has a higher bone turnover rate than cortical bone 5 and has direct contact with the majority of the implant surface. 6 Accordingly, it influences the healing and osseointegration process at the implantbone surface.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic imaging of trabecular bone microstructure for oral implants: a literature review

Ibrahim¹,

Parsa²,

Hassan³

et al. 2013

Dentomaxillofacial Radiology

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Several dental implant studies have reported that radiographic evaluation of bone quality can aid in reducing implant failure. Bone quality is assessed in terms of its quantity, density, trabecular characteristics and cells. Current imaging modalities vary widely in their efficiency in assessing trabecular structures, especially in a clinical setting. Most are very costly, require an extensive scanning procedure coupled with a high radiation dose and are only partially suitable for patient use. This review examines the current literature regarding diagnostic imaging assessment of trabecular microstructure prior to oral implant placement and suggests cone beam CT as a method of choice for evaluating trabecular bone microstructure.

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Bone Quality: A Reality for the Process of Osseointegration

Cited by 60 publications

References 32 publications

Trabecular bone histomorphometric measurements and contrast-to-noise ratio in CBCT

Trabecular bone histomorphometric measurements and contrast-to-noise ratio in CBCT

Wave front migration of endothelial cells in a bone-implant interface

Diagnostic imaging of trabecular bone microstructure for oral implants: a literature review

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