Bone repletion in calcium deficient rats fed a high calcium diet

Stauffer, Martha E.; Baylink, David J.; Wergedal, Jon E.; Rich, Charles L.

doi:10.1007/bf02061954

Cited by 48 publications

(23 citation statements)

References 10 publications

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“…,um/day, respectively (23). The discrepancies in the reported bone mineralization rates in rats (22)(23)(24)(25) are most likely a result of differences in the experimental conditions, the weights and ages of the animals, and the bones studied.…”

Section: Discussionmentioning

confidence: 99%

“…The discrepancies in the reported bone mineralization rates in rats (22)(23)(24)(25) are most likely a result of differences in the experimental conditions, the weights and ages of the animals, and the bones studied. Both the rat tibia and f'emur are complicated by structural asymmetry and cortical drift (25)(26).…”

Section: Discussionmentioning

confidence: 99%

“…Our animals achieved this weight after approximately 7 days of'lithium treatment. Hence, while mineralization was occurring at the periosteal surf'ace during the entire 4 wk of' lithium Previous studies by others have employed medtullary cavity area as an index of increased (23) or decreased (27) bone resorption. Despite suppression of bone formation associated with lithium treatment, we did not observe significaint changes in medullary cavity or cortical bonie area.…”

Section: Discussionmentioning

confidence: 99%

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Lithium inhibition of bone mineralization and osteoid formation.

Baran¹,

Schwartz²,

Bergfeld³

et al. 1978

J. Clin. Invest.

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A B S T R A C T Lithium chloride administration to growing rats, which resulted in circulating lithium levels of 1.4 meq/liter, was attended by significant suppression of bone mineralization and organic matrix synthesis as assessed by tetracycline labeling and histological quantitation of osteoid, respectively. These effects of lithium were not associated with changes in animal behavior, nor were there any significant differences in blood levels of calcium, phosphorus, alkaline phosphatase, creatinine, pH, or parathyroid hormone. The data suggest that lithium inhibition of bone mineralization is secondary to suppression of osteoid formation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lithium inhibition of bone mineralization and osteoid formation.

Baran¹,

Schwartz²,

Bergfeld³

et al. 1978

J. Clin. Invest.

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“…The continuous lowering of the serum calcium con tent, when traumatization proceeds, has some conse quences from the ThAA-stimulated increase in GAG synthesis which are known to be consumers of serum calcium [Rasmussen and Bordier, 1974] and even some other inorganic materials [Stuhlsatz et al, 1982], The lowered serum calcium values are also supposed to have a direct inhibition of the formation of new bone in the alveolar crest [Stauffer et al, 1972].…”

Section: Discussionmentioning

confidence: 99%

Influence of Experimental Liver Injury on Rat Blood and Alveolar Bone under Stress

Lassila¹,

Virtanen²

1984

Cells Tissues Organs

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Experimental liver injury was induced to test rats with a daily injection of thioacetamide (ThAA). The doses used for intraperitoneal administrations were 50 mg/kg body weight. The loss of body weight in the 3-week test period was 15%. In the liver there was seen progressive changes which displayed cell necrosis and regeneration. The influence of ThAA on rat blood and serum was checked using standard biochemical assays consisting of the percentage of blood obtainable and the serum/blood ratio and analysis of serum alanine transferase, serum alkaline phosphatase, serum creatinine, and hydroxyproline in the acute, subacute, chronic, and necrotic stage of liver injury. With ThAA injections, the stimulated rate of glycosaminoglycan synthesis had its association to the serum calcium content. It decreased continuously as function of traumatization time. In the 3-week test period, histological findings show in the alveolar bone, around the teeth, when under occlusal stress and ThAA traumatization, the distinct decrease in osteoblastic activity and less osteoids indicating thus the decreased formation of new bone. Conspicuous osteoclastic resorption was also seen in the same area.

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“…Rats, being less able than mice to increase intestinal calcium absorption under these conditions, exhibit a relatively greater decrease of bone ash. On the other hand, percent calcium absorption and retention decrease when rats are switched from a low-calcium to a high-calcium diet (3), resulting in a higher concentration of bone calcium (3) and an increased bone mass (14). This reversal is not always complete and depends largely on the duration of both the ' With the technical assistance of R. Lówy and A. Golan.…”

mentioning

confidence: 99%

Effect of Repletion with Dietary Calcium on Composition and Mechanical Properties of Bone of Calcium-Deprived Rats

Galfsky¹,

Wolinsky²,

Simkin³

et al. 1975

Ann Nutr Metab

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Four groups of rats were fed a low-calcium diet (0.02 %) and two groups a normal calcium diet (0.50 %). After 2 weeks one group from each dietary calcium level was sacrificed and the femurs examined. The remaining three groups which had been kept on the low-calcium diet were then given diets richer in calcium: 0.25, 0.35 and 0.5 %. The remaining group on the normal calcium diet continued receiving it. After two more weeks all animals were sacrificed and their femurs examined. Rats fed the low-calcium diet lagged behind in weight gain; ash content, breaking strength, and modulus of elasticity of their femurs were much lower than those of animals on the normal calcium diet. Feeding diets with increasing calcium content increased bone ash and improved mechanical properties. However, improvement of breaking strength and elasticity did not parallel strictly increases in mineralization. Repletion with a normal calcium diet (0.50 %) failed to increase bone ash to normal levels but mechanical properties were improved by repletion with substantially lower dietary calcium levels. Maximal breaking strength was obtained by repletion feeding with a dietary calcium level which failed to increase bone ash. It seems that factors other than mineralization determine breaking strength and elasticity of bone recovering from calcium deprivation.

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Bone repletion in calcium deficient rats fed a high calcium diet

Cited by 48 publications

References 10 publications

Lithium inhibition of bone mineralization and osteoid formation.

Lithium inhibition of bone mineralization and osteoid formation.

Influence of Experimental Liver Injury on Rat Blood and Alveolar Bone under Stress

Effect of Repletion with Dietary Calcium on Composition and Mechanical Properties of Bone of Calcium-Deprived Rats

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