Bone turnover markers in serum and periodontal microenvironments

Abstract

This system demonstrated that multiple markers of bone turnover can be harvested by irrigation from periodontal bone microenvironments. Bone turnover profiles from periodontal bone surfaces and GCF differed from systemic bone turnover profiles (serum) and may be valuable in tracking site-specific responses to disease or treatment.

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

“…It has been previously shown that bone turnover profiles from periodontal bone surfaces and GCF differed from systemic bone turnover profiles [33]. In periodontitis osteocalcin has been suggested to be a marker of bone formation where bone resorption is greater than formation, and GCF osteocalcin levels are more revealing than serum or saliva levels regarding bone turnover in periodontium [52].…”

“…In the present cross-sectional study, both osteocalcin as a marker of bone formation and NTx as a marker of bone resorption were investigated to have an idea about the change in bone turnover in different periodontal disease, in other words how the levels of these biochemical markers changes in GCF while the disease progress from gingivitis to periodontitis. Osteocalcin/NTx ratio has been suggested to be a marker of bone turnover normalized with respect to resorption [33]. In the present study, this ratio was also calculated in order to evaluate how bone turnover changes in different periodontal diseases.…”

“…In previous studies, the bestknown markers of the bone turnover have been widely investigated in GCF samples of patients with different periodontal diseases and implicated to be associated with the progression of periodontal diseases [28][29][30]. Several investigations provided contradictory evidence about the role of osteocalcin in GCF of patients with periodontitis [31][32][33]. Little is known about the role and presence of the novel NTx in periodontal diseases.…”

Gingival Crevicular Fluid Osteocalcin Levels in Elderly Patient with Periodontal Disease

“…Lee et al 14 demonstrated similar GCF osteocalcin levels in diseased and healthy sites in patients with CP. Wilson et al 15 could not detect osteocalcin in GCF of untreated periodontitis patients. On the other hand, Nakashima et al 16 found elevated osteocalcin total amount in GCF from periodontitis sites compared to those found in healthy and gingivitis sites.…”

“…Osteocalcin accepted as a valid marker of bone turnover when resorption and formation are coupled 6,8 . It has been previously shown that bone turnover profiles from periodontal bone surfaces and gingival crevicular fluid (GCF) differed from systemic bone turnover profiles 9 . In periodontitis osteocalcin has been suggested to be a marker of bone formation where bone resorption is greater than formation, and GCF osteocalcin levels are more revealing than serum or saliva levels regarding bone turnover in periodontium 5 .To the best of our knowledge, there is no study evaluating the effects of osteocalcin levels on the GCF in elderly patient.…”