Osteocalcin and N-telopeptides of type I collagen marker levels in gingival crevicular fluid during different stages of orthodontic tooth movement

Alfaqeeh, Sarah A.; Anil, Sukumaran

doi:10.1016/j.ajodo.2011.03.005

Cited by 17 publications

(19 citation statements)

References 45 publications

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“…Analysis the results of the current study, noted a large variation in the absolute level of OC in GCF samples collected from all participants, although most of the samples showed an increase in OC level after day 10 and 14. The maximum amounts of OC detected at day 10 represented approximately 2–12 pg/sample, which comes with results of Alfaqeeh and Anil[ 27 ] where they reported a significant changes in the level of OC on days 7, 14, 21, and the peak occurred on day 14 after canine retraction. In addition, it was reported in the elevation of alkaline phosphatase at days 14 and 28 after activation of orthodontic appliance.…”

Section: Discussionsupporting

confidence: 87%

Detection of ostecalcin in gingival crevicular fluid in a group of orthodontic patients

Nassrawin

2018

J Int Soc Prevent Communit Dent

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Aim:To detect osteocalcin (OC) in gingival crevicular fluid (GCF) and to monitor the concentration of OC at what stage inflammation and bone resorption reaches their maximum following orthodontic activation.Materials and Methods:GCF samples were collected from six adult orthodontic patients (mean age = 22.3, range 20–24 years) on 3, 7, 10, 14, 21, 28, and 35 days after activation of orthodontic appliance, from the tooth surface where bone resorption was expected to occur. A total of 330 GCF sample were collected using filter paper strip, the volume measured by weighing. OC was analyzed using Enzyme-Linked immunoassay technique. Data were analyzed using the Statistical Package for Social Sciences software, SPSS (SPSS Inc., Chicago, IL, USA) version 15.Results:An increase in GCF volume and flow rate was noted in the 10th day after activation of the orthodontic appliance activation; however, due to high-standard deviation, the result was not significant. OC was detected in all GCF samples. The amount and concentration were quite variable. Increase in the amount of OC was observed between days 7 and 14.Conclusion:OC was detected in all samples. The quantity of OC increased at day 10 in a number of samples. There was no obvious association between OC concentration and time of collection.

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Section: Discussionsupporting

confidence: 87%

Detection of ostecalcin in gingival crevicular fluid in a group of orthodontic patients

Nassrawin

2018

J Int Soc Prevent Communit Dent

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“…In the last decades, in an effort to develop clinical tools to measure and accelerate tooth movement in humans, the measurement of specific markers in the gingival crevicular fluid (GCF) has been introduced (19). Previous studies have shown that some of these markers are key regulators of bone remodelling during orthodontic movement and that their levels in GCF may change after application of orthodontic force (20)(21)(22). For example, receptor activator of nuclear factor-kappa B ligand (RANKL) increases and osteoprotegerin (OPG) decreases after 1 day at sites of compression in patients undergoing maxillary canine distalization (23,24).…”

Section: Discussionmentioning

confidence: 99%

Slow and fast orthodontic tooth movement: an experimental study on humans

Giannopoulou

Dudic

Pandis

et al. 2015

EORTHO

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“…Therefore, it remains to be established whether osteocalcin GCF levels can be used as markers of bone turnover. [ 13 ]…”

Section: Metabolic Products Of Paradental Remodelingmentioning

confidence: 99%

Biomarkers in orthodontic tooth movement

et al. 2015

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Tooth movement by orthodontic treatment is characterized by remodeling changes in the periodontal ligament, alveolar bone, and gingiva. A reflection of these phenomenons can be found in the gingival crevicular fluid (GCF) of moving teeth, with significant elevations in the concentrations of its components like, cytokines, neurotransmitters, growth Factors, and a arachidonic acid metabolites. GCF arises at the gingival margin and can be described as a transudate or an exudate. Several studies have focused on the composition of GCF and the changes that occur during orthodontic tooth movement (OTM). GCF component analysis is a non-invasive method for studying the cellular response of the underlying periodontium. Clinically, GCF can be easily collected using platinum loops, filter paper strips, gingival washings, and micropipettes. A number of GCF biomarkers involve in bone remodeling during OTM. The data suggest that knowledge of all the biomarkers present in the GCF that can be used to mark the changes in tooth that is undergoing orthodontic treatment may be of clinical usefulness leading to proper choice of mechanical stress to improve and to shorten treatment time and avoid side effects.

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Osteocalcin and N-telopeptides of type I collagen marker levels in gingival crevicular fluid during different stages of orthodontic tooth movement

Cited by 17 publications

References 45 publications

Detection of ostecalcin in gingival crevicular fluid in a group of orthodontic patients

Detection of ostecalcin in gingival crevicular fluid in a group of orthodontic patients

Slow and fast orthodontic tooth movement: an experimental study on humans

Biomarkers in orthodontic tooth movement

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