BoneCeramic graft regenerates alveolar defects but slows orthodontic tooth movement with less root resorption

Ru, Nan; Liu, Sean Shih-Yao; Bai, Yuxing; Li, Song; Liu, Yunfeng; Wei, Xiaoxia

doi:10.1016/j.ajodo.2015.09.027

Cited by 34 publications

(64 citation statements)

References 29 publications

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“…Therefore, a priori sample size calculation with regard to root resorption during orthodontic tooth movement in different cleft repairs was performed using one-way ANOVA (analysis of variance). The sample size calculation was based on the mean apical root resorption reported by Ru et al 19 in animals were xenogeneic and synthetic bone substitutes were used for cleft repair. The sample size estimation relying on the large observed effect (0.0605 mm 3 vs. 0.089 mm 3 ) and the corresponding difference between the xenogeneic and autologous bones was assumed to be half of the difference between the xenogeneic and synthetic bone substitutes.…”

Section: Methodsmentioning

confidence: 99%

“…In this context, Ru et al compared a synthetic bone substitute based on a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) with a bovine xenograft in a corresponding alveolar defect model in rats 20 . They found the least amount of tooth movement, volumes and craters of root resorption, and the highest bone volume fraction (BV/TV), trabecular number, and mean trabecular thickness in the synthetic bone group 19 . Human allografts are also acceptable alternatives for cleft repair as reduced operation time, shortened hospital stays, and less graft resorption over time were reported when they were used 23 .…”

Section: Introductionmentioning

confidence: 97%

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Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats

Möhlhenrich

Kniha

Magnuska

et al. 2021

Sci Rep

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To minimize the postoperative risks posed by grafting autologous transplants for cleft repair, efforts are being made to improve grafting materials for use as potential alternatives. The aim of this study was to compare the bone graft quality of different bone substitutes including the gold standard autografts during the healing processes after cleft repair in the context of orthodontic treatment. In 21 Wistar rats, a complete, continuity-interrupting cleft was created. After 4 weeks, cleft repair was performed using autografts from the hips’ ischial tuberosity, human xenografts, or synthetic bone substitutes [beta-tricalcium phosphate (β-TCP)/hydroxyapatite (HA)]. After another 4 weeks, the first molar movement was initiated in the reconstructed jaw for 8 weeks. The bone remodeling was analyzed in vivo using micro-computed tomography (bone mineral density and bone volume fraction) and histology (new bone formation). All the grafting materials were statistically different in bone morphology, which changed during the treatment period. The β-TCP/HA substitute demonstrated less resorption compared to the autologous and xenogeneic/human bone, and the autografts led to a stronger reaction in the surrounding bone. Histologically, the highest level of new bone formation was found in the human xenografts, and the lowest was found in the β-TCP/HA substitute. The differences between the two bone groups and the synthetic materials were statistically significant. Autografts were confirmed to be the gold standard in cleft repair with regard to graft integration. However, parts of the human xenograft seemed comparable to the autografts. Thus, this substitute could perhaps be used as an alternative after additional tissue-engineered modification.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats

Möhlhenrich

Kniha

Magnuska

et al. 2021

Sci Rep

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“…In corresponding animal research, various rat models have been described as focusing the bone responses at recipient sites [1][2][3][5][6][7][8]31,32 and different areas have been established to enable critical-size bone defects in rat models 10 . These regions can also be viewed as potential donor sites for grafting non-vascular allografts in rats, www.nature.com/scientificreports/ which could be of interest in cases of jaw reconstruction.…”

Section: Discussionmentioning

confidence: 99%

“…Different rodent models have been established in animal research for the treatment of clefts focusing the bone responses in grafted sites [1][2][3][4][5][6][7][8] . These alveolar cleft repairs can be performed using various dental materials that include natural bone materials like autografts, allografts or xenografts as well as synthetic bone substitutes such as bioceramics, polymers or biocomposites 9 .…”

mentioning

confidence: 99%

Ischial tuberosity: new donor site for bone grafts in animal cleft research

Möhlhenrich

Kniha

Magnuska

et al. 2020

Sci Rep

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In the context of cleft repair in animal research in rat models, different areas can be used for bone grafting. The aim of the present study was to present the tuberosity of the ischium as a new donor site and to evaluate its quality in relation to an artificial alveolar cleft. Four weeks after creating experimental alveolar clefts in seven Wistar rats, the repair was performed in the now twelve-week-old male animals using bone blocks grafted from the ischial tuberosity. Two days before surgery and two as well as twenty-eight days after surgery, microCT scans were performed, and the grafted bone blocks were analyzed regarding height, width, thickness, and volume. Additionally, bone mineral density (BMD) and bone volume fraction (BV/TV) were measured in the repaired cleft. The mean bone volume of the graft was about 19.77 ± 7.77mm3. Immediately after jaw reconstruction the BMD and BV/TV were about 0.54 ± 0.05 g/cm3 and 54.9 ± 5.07% for the transplant and about 1.13 ± 0.08 g/cm3 and 94.5 ± 3.70%, respectively, for the surrounding bone. Four weeks later the BMD and BV/TV were about 0.57 ± 0.13 g/cm3 and 56.60 ± 13.70% for the transplant and about 11.17 ± 0.07 g/cm3 and 97.50 ± 2.15%, respectively, for the surrounding bone. A hip fracture was found in four of the animals after surgery. The ischial tuberosity offers large bone blocks, which are sufficient for cleft repair in the rat model. However, the bone quality regarding BMD and BV/TV is less compared with the surrounding bone of the alveolar cleft, even after a period of 4 weeks, despite recognizable renovation processes.

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“…39 Recently, a study by Ru et al in a rat model showed results similar to those of the present study, that is, impaired OTM in the BB regenerated sites. 40 The differences…”

Section: Discussionmentioning

confidence: 99%

Bone regeneration with bovine bone impairs orthodontic tooth movement despite proper osseous wound healing in a novel mouse model

Klein

Fleissig

Stabholz

et al. 2018

Journal of Periodontology

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BoneCeramic graft regenerates alveolar defects but slows orthodontic tooth movement with less root resorption

Cited by 34 publications

References 29 publications

Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats

Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats

Ischial tuberosity: new donor site for bone grafts in animal cleft research

Bone regeneration with bovine bone impairs orthodontic tooth movement despite proper osseous wound healing in a novel mouse model

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