Boronate–dextran: An acid-responsive biodegradable polymer for drug delivery

Fabrication of boronic acid-functionalized nanoparticles via boronic acid–diol complexation for drug delivery

“…1 shows the FT-IR spectra of dextran, PMAPBA and PMAPBA 1 /dextran 0.2 nanoparticles. 20 These results conrmed that the nanoparticles were fabricated by the complexation of PMAPBA and dextran. Aer dialysis to remove free dextran, the nanoparticle suspension was freeze-dried for FT-IR characterization.…”

“…Fig. 20,30 The absorption peaks of the nanoparticles in the region 1461-1300 cm À1 were ascribed to C-H bending vibration of saturated hydrocarbon in dextran (at 1424 and 1353 cm À1 ) and PMAPBA (at 1425 and 1342 cm À1 ). For PMAPBA 1 /dextran 0.2 nanoparticles, the dextran concentration was 0.2 mg mL À1 .…”

“…[7][8][9][10][11][12][13][14][15] However, the stability of the formed nanoparticles is generally limited, especially in ionic, acidic and basic environments. 19,20 Recently, there has been a great deal of interest in studying the interactions between boronic acids and diol-containing compounds. The boronic acids can react rapidly and reversibly with diol groups.…”

Light- and pH-activated intracellular drug release from polymeric mesoporous silica nanoparticles

“…[19] So it provides a good candidate for the light-sensitive valve. pHresponsiveness has always been a hot topic in the controlled drug release field, [20][21][22] since the pH value in tumor intra/intercellular milieu (5.0 ~ 6.8) is lower than that of normal extracellular matrices and blood (≈7.4). [23] Biocompatible poly [2-(dimethylamino)ethyl acrylate] (PDMAEA) exhibits pH-sensitive behavior, attributed to the protonation of the tertiary amine groups.…”

Acid-labile boronate-bridged dextran–bortezomib conjugate with up-regulated hypoxic tumor suppression

“…6 Apart from the NF-kB signaling pathway, the endoplasmic reticulum stress (ERS)-induced apoptosis occurs after BTZ incubation, which is triggered by the hypoxia of the tumor microenvironment. 6 The boronate-based polymeric materials have been widely applied in various biomedical fields, such as drug delivery, 9 tissue engineering, 10 etc. 7 In other words, the activation of the ERS signaling pathway can be responded by the expression of CHOP.…”