Botulinum Toxin-A to Improve Urethral Wound Healing: An Experimental Study in a Rat Model

Şahinkanat, Tayfun; Özkan, Keramettin Uğur; Çıralık, Harun; Öztürk, Şenol; Resim, Sefa

doi:10.1016/j.urology.2008.07.051

Cited by 33 publications

(21 citation statements)

References 19 publications

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“…Additionally, BTX-A is also reported to improve radiation fibrosis syndrome [18]. Sahinkanat et al [19] demonstrated that BTX-A inhibits the production of collagen during urethral wound healing. Chen et al [20] reported that an intra-articular injection of BTX-A retards the process of fibrosis and can be used to treat frozen shoulder.…”

Section: Introductionmentioning

confidence: 99%

Reduction of adhesion formation after knee surgery in a rat model by botulinum toxin A

Gao

Liu

et al. 2017

Bioscience Reports

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Adhesion of the knee is a major concern after knee surgery, the treatment of which is difficult. Botulinum toxin A (BTX-A) injection is demonstrated as efficient in treating knee adhesion after surgery. However, the treatment outcomes and the mechanism of action are not yet determined. The aim of the present study was to examine the effects and molecular mechanism of a BTX-A treatment in preventing adhesion of the knee. Twenty-four Wistar rats were randomly divided into a BTX-A treatment group and a control group. BTX-A or saline was injected into the cavity of the knee in the BTX-A treatment or control group respectively. Gross and histopathological examinations of interleukin 1 (IL-1) and fibroblast growth factor (FGF) levels, as well as fibroblast cell numbers, were assessed in the knee intra-articular adhesions in each group 6 weeks after recovery from the surgery. Macroscopic observations showed a significant reduction in adhesion severity in the BTX-A treatment group compared with the control group. In addition, the levels of IL-1 and FGF were lower and the number of fibroblasts was smaller in the BTX-A treatment group compared with those in the control group. BTX-A prevented intra-articular adhesion of knee in the rats, which might be associated with reduced expressions of IL-1 and FGF.

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Section: Introductionmentioning

confidence: 99%

Reduction of adhesion formation after knee surgery in a rat model by botulinum toxin A

Gao

Liu

et al. 2017

Bioscience Reports

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“…Because of all these characteristics, rat skin is regarded as a considerable model to study various applications. 2,18,24,[26][27][28] In this study, it was observed that skin contraction had considerably decreased, particularly throughout the 60 days, in the group applied with BTX-A. In histologic examinations, in groups of BTX-A application, there was a considerable increase in collagen amount as well as the connected tissue cells, and the collagen structure showed fibriller formation.…”

Section: Discussionmentioning

confidence: 51%

“…2,18,24,[26][27][28] Rat skin is relatively similar to the human skin in that it includes epidermis, dermis, subcutaneous tissue, and sebaceous tissue. Rat skin is a multilayered epithelial structure, consisting of 2 to 3 lines of cells, a solid Keratin layer, and stratum spinosum.…”

Section: Discussionmentioning

confidence: 99%

“…2,9,14,15 It is applied to the pectoral muscles after subpectoral implant placements, which induces reversible denervation and better cosmetic result as well as a painless postoperative period. 2,9,13,15,[17][18][19][20][21][22][23] Moreover, in experimental studies, BTX-A application prevented contraction of muscle flaps by which it could allow the stabilization of muscle flaps. It was experimentally indicated that BTX-A could be used as an alternative way to denervate pedicle muscle flaps.…”

Section: Botox Informationmentioning

confidence: 99%

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The Effects of Botulinum Toxin A on the Wound and Skin Graft Contraction

Kucukkaya¹,

Irkoren²,

Ozkan³

et al. 2014

Journal of Craniofacial Surgery

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“…Progression from strongly positive to negative was considered to be significant. 16 Sections were photographed using a Nikon 50i photomicroscope and NIS elementary software.…”

Section: Histologic Examinationmentioning

confidence: 99%

Effect of Mitomycin, Bevacizumab, and 5-Fluorouracil to Inhibit Urethral Fibrosis in a Rabbit Model

Üyetürk

Gücük²,

Fırat³

et al. 2014

Journal of Endourology

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Botulinum Toxin-A to Improve Urethral Wound Healing: An Experimental Study in a Rat Model

Cited by 33 publications

References 19 publications

Reduction of adhesion formation after knee surgery in a rat model by botulinum toxin A

Reduction of adhesion formation after knee surgery in a rat model by botulinum toxin A

The Effects of Botulinum Toxin A on the Wound and Skin Graft Contraction

Effect of Mitomycin, Bevacizumab, and 5-Fluorouracil to Inhibit Urethral Fibrosis in a Rabbit Model

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