BackgroundAmino acid neurotransmitters and nitric oxide (NO) are involved in the pathogenesis of major depressive disorder (MDD). Here we want to establish whether changes in their plasma levels may serve as biomarker for the melancholic subtype of this disorder.MethodsPlasma levels of glutamic acid (Glu), aspartic acid (Asp), glycine (Gly), gamma-aminobutyric acid (GABA), and NO were determined in 27 medicine-naïve melancholic MDD patients and 30 matched controls. Seven of the MDD patients participated also in a follow-up study after 2 months’ antidepressant treatment. The relationship between plasma and cerebral-spinal fluid (CSF) levels of these compounds was analyzed in an additional group of 10 non-depressed subjects.ResultsThe plasma levels of Asp, Gly and GABA were significantly lower whereas the NO levels were significantly higher in melancholic MDD patients, also after 2 months of fluoxetine treatment. In the additional 10 non-depressed subjects, no significant correlation was observed between plasma and CSF levels of these compounds.ConclusionThese data give the first indication that decreased plasma levels of Asp, Gly and GABA and increased NO levels may serve as a clinical trait-marker for melancholic MDD. The specificity and selectivity of this putative trait-marker has to be investigated in follow-up studies.

Icing occurs each winter along the floodplain of the Kuuguluk River in the continuous permafrost zone at Salluit in Nunavik (Quebec), Canada. The source of successive water overflows which thicken and enlarge this ice cover over time is suprapermafrost groundwater discharging from a talik below the riverbed. Electrical resistivity tomography was used to delineate the talik, while water level and temperature dataloggers were used to assess the thermo‐hydraulic conditions of the riverbed. The mean annual riverbed temperature was 1.8°C in 2016 while the mean annual air temperature was −6.0°C. Hydraulic heads below the ice cover as high as 2.8 m and events of abrupt decreases in hydraulic head due to suprapermafrost groundwater overflow through cracks in the ice cover were monitored. An analytical solution based on beam mechanics theory was used to assess the water pressure‐induced stresses which are sufficient to fracture the ice cover. A detailed conceptual model of the talik and icing dynamics is proposed to explain the cryo‐hydrogeological processes taking place in this complex groundwater–river system. The groundwater pressure buildup in the talik during the winter is due to constricted flow of suprapermafrost groundwater in the talik. These results have implications for understanding the dynamics of river taliks and their use as potential water supplies in northern communities.

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