Bouginage and Steroids Used Singly or in Combination in Experimental Corrosive Esophagitis

Knox, W G; Scott, J R; Zintel, Harold A.; Guthrie, Richard D.; McCabe, Robert E.

doi:10.1097/00000658-196712000-00008

Cited by 41 publications

(7 citation statements)

References 15 publications

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“…In 1950, Spain and his colleagues (15, 16) reported that the early administration of cortisone has an antiinflammatory effect on granulation tissue by inhibiting fibroplasia. Following experimental studies on dogs, cats and rats, other researchers have supported the same statement (6,10,12,14).…”

Section: Discussionmentioning

confidence: 93%

The Effect of Steroid Treatment on Corrosive Oesophageal Burns in Children*

Keskin

Okur²,

Koltuksuz³

et al. 1991

Eur J Pediatr Surg

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A retrospective study was done on corrosive oesophageal burns to ascertain the preventive effect of corticosteroids on stricture development. Within the last 12 years 351 children were admitted to our medical centre with a history of corrosive agent ingestion. In 235 of these the diagnosis of oesophageal burn was confirmed by means of oesophagoscopy. Children admitted within the first 48 hours received steroid, antibiotic and fluid therapy while fluid and antibiotics were given, if needed, in the rest. Forty-six of the children were lost to follow-up. The type of corrosive agent, the admission period, the degree of the burn and the stricture development were used as parameters. Stricture development was found statistically significant in late admitted patients vs. early admissions. This retrospective study suggests the effectiveness of corticosteroid treatment in preventing the stricture development.

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Section: Discussionmentioning

confidence: 93%

The Effect of Steroid Treatment on Corrosive Oesophageal Burns in Children*

Keskin

Okur²,

Koltuksuz³

et al. 1991

Eur J Pediatr Surg

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“…The use of steroid therapy as an adjunct to dilatation for esophageal stricture secondary to caustic ingestion in adults was described in 1967 by Knox et al, after several animal studies laid the groundwork for its use. 75,76 It has now become a standard treatment modality for the treatment of corrosive esophageal stricture in adults. 11,77 More recently, two randomized controlled trials have supported the use of steroid injection for the treatment of peptic strictures as well.…”

Section: Steroidsmentioning

confidence: 99%

Anastomotic Stricture after Esophageal Atresia Repair: A Critical Review of Recent Literature

2013

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Anastomotic strictures (ASs) complicate the postoperative course of roughly one-third of all patients with esophageal atresia with or without tracheoesophageal fistula. Its development is multifactorial, but is due in part to tension on the anastomosis, gastroesophageal reflux disease, and the presence of a leak in the early postoperative period. Efforts at reducing the rate of AS have been largely unsuccessful, although meticulous technique and aggressive acid suppression remain the cornerstones of perioperative care. Once an AS has been confirmed, the first-line treatment remains a course of esophageal dilatation. Adjuncts to dilatation are frequently required, including steroid injection or the topical application of mitomycin C. Currently, there is insufficient evidence to promote one at the expense of the other. Esophageal stenting has recently been added to the algorithm of treatment, although additional literature is required to confirm its safety and efficacy. Finally, stricture resection followed by primary esophageal anastomosis or, rarely, esophageal replacement with an interposition graft remain options for AS refractory to all other forms of treatment.

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“…All of these investigators have used a variety of animal species whose esophageal stricture differed considerably from each other. Although in most of the similar experimental studies, lye has been used, there are different opinions about the amount, concentration and duration of the caustic agent [3,[13][14][15]. Ingestions of alkaline solutions with a pH of less than 11.5 are considered relatively safe, whereas those with a pH exceeding this level may produce acute perforation and death or, more typically, esophageal stenosis and significant morbidity [1,13,16,17].…”

Section: Discussionmentioning

confidence: 99%

“…Currently, two treatment options are available for prevention of stricture; dilatation or maintenance of an esophageal lumen by mechanical means and pharmacological modification of wound healing [2]. Dilatation of the injured tissues by bougienage increases the risk of perforation [3]. Several reports indicated that intraluminal silastic stents reduce stricture formation [4,5].…”

Section: Introductionmentioning

confidence: 99%

Influence of Pentoxifylline and Interferon-Alpha on Prevention of Stricture due to Corrosive Esophagitis

Apaydin¹,

Paksoy²,

Artiş³

et al. 2001

Eur Surg Res

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The effects of pentoxifylline (PTX) and interferon α (IFN-α) in the prevention of strictures due to corrosive esophagitis in rats were investigated. Forty rats were randomly divided into four equal groups. Corrosive esophagitis was induced in all groups by application of 37.5% NaOH to the distal esophagus for a period of 90 s followed by saline rinse. Histopathologic damage was significantly lower in the PTX and IFN-α-treated groups than in the untreated group. During the study period, PTX and INF-α-treated animals showed a significant increase in body weight when compared to controls. However, PTX provided more significant prevention of stricture formation than IFN-α. In the PTX-treated group, the wall thickness and quantity of hydroxyprolin were significantly lower than in the untreated and IFN-α-treated groups. Stenosis index in the PTX group was significantly reduced compared to the control group. PTX prevents the stricture formation due to corrosive esophagitis in this experimental model. IFN-α was also shown to prevent stricture formation when considering amelioration of histopathologic damage and increase in body weight.

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Bouginage and Steroids Used Singly or in Combination in Experimental Corrosive Esophagitis

Cited by 41 publications

References 15 publications

The Effect of Steroid Treatment on Corrosive Oesophageal Burns in Children*

The Effect of Steroid Treatment on Corrosive Oesophageal Burns in Children*

Anastomotic Stricture after Esophageal Atresia Repair: A Critical Review of Recent Literature

Influence of Pentoxifylline and Interferon-Alpha on Prevention of Stricture due to Corrosive Esophagitis

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