Brain circuitries involved in emotional interference task in major depression disorder

Chechko, Natalia; Augustin, Marc; Zvyagintsev, Mikhail; Schneider, Frank; Habel, Ute; Kellermann, Thilo

doi:10.1016/j.jad.2013.01.013

Cited by 52 publications

(42 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, multiple groups have reported trauma-related changes to the medial temporal gyrus, with its putative role in integrating memory function and imagery (e.g., Shin et al, 2001; Dickie et al, 2008; Moores et al, 2008). The lingual gyrus, with its likely role in visual processing and integration, has also been implicated in imaging studies of depression, conflict resolution, and impaired reward response (Dichter et al, 2009; Kessler et al, 2011; Chechko et al, 2013), whereas the postcentral gyrus has been associated with depression and pain (Bar et al, 2007). Taken together, we interpret this to mean that thalamic hyperconnectivity is associated with broad-based disruptions between important brain functions, inclusive of salience, memory and visual processing and sensation, that corresponds to both the literature and our clinical experience with this population.…”

Section: Discussionmentioning

confidence: 99%

Early life stress predicts thalamic hyperconnectivity: A transdiagnostic study of global connectivity

Philip

Tyrka

Albright

et al. 2016

Journal of Psychiatric Research

View full text Add to dashboard Cite

Early life stress (ELS) is an established risk factor for psychiatric illness and is associated with altered functional connectivity within- and between intrinsic neural networks. The widespread nature of these disruptions suggests that broad imaging measures of neural connectivity, such as global based connectivity (GBC), may be particularly appropriate for studies of this population. GBC is designed to identify brain regions having maximal functional connectedness with the rest of the brain, and alterations in GBC may reflect a restriction or broadening of network synchronization. We evaluated whether ELS severity predicted GBC in a sample (N=46) with a spectrum of ELS exposure. Participants included healthy controls without ELS, those with at least moderate ELS but without psychiatric disorders, and a group of patients with ELS− related psychiatric disorders. The spatial distribution of GBC peaked in regions of the salience and default mode networks, and ELS severity predicted increased GBC of the left thalamus (corrected p < .005, r = .498). Thalamic connectivity was subsequently evaluated and revealed reduced connectivity with the salience network, particularly the dorsal anterior cingulate cortex (corrected p < .005), only in the patient group. These findings support a model of disrupted thalamic connectivity in ELS and trauma-related negative affect states, and underscore the importance of a transdiagnostic, dimensional neuroimaging approach to understanding the sequelae of trauma exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

Early life stress predicts thalamic hyperconnectivity: A transdiagnostic study of global connectivity

Philip

Tyrka

Albright

et al. 2016

Journal of Psychiatric Research

View full text Add to dashboard Cite

show abstract

“…Nonetheless, patients with acute mood episodes show reduced dlPFC activity during tasks that require emotional regulation and emotional anticipation [99][100][101][102]. In addition, patients show reduced functional connectivity among the OFC, the dorsal ACC, the precuneus, and the amygdala [103,104].…”

Section: Neurobiological Studies Have Shown Thatmentioning

confidence: 99%

Social cognition in major depressive disorder: A new paradigm?

Billeke

Boardman

Doraiswamy

2013

Translational Neuroscience

View full text Add to dashboard Cite

Social cognition refers to the brain mechanisms by which we process social information about other humans and ourselves. Alterations in interpersonal and social functioning are common in major depressive disorder, though only poorly addressed by current pharmacotherapies. Further standardized tests, such as depression ratings or neuropsychologic tests, used in routine practice provide very little information on social skills, schemas, attributions, stereotypes and judgments related to social interactions. In this article, we review recent literature on how healthy human brains process social decisions and how these processes are altered in major depressive disorder. We especially focus on interactive paradigms (e.g., game theory based tasks) that can reproduce daily life situations in laboratory settings. The evidences we review, together with the rich literature on the protective role of social networks in handling stress, have implications for developing more ecologically-valid biomarkers and interventions in order to optimize functional recovery in depressive disorders.

show abstract

“…Interestingly, the rACC was activated during negative self-referential processing, and this activation was related to the severity of patients’ depressive symptoms. Other investigators have found hypoactivity in MDD during an emotional Stroop task in regions important for conflict resolution, including the DLPFC, parietal, and extrastriate cortices combined with amygdala hyperactivity (Chechko et al, 2013). …”

Section: How the Neuroscience Of Depression Can Inform Assessmentmentioning

confidence: 99%

The neuroscience of depression: Implications for assessment and intervention

Singh

Gotlib

2014

Behaviour Research and Therapy

View full text Add to dashboard Cite

Major Depressive Disorder (MDD) is among the most prevalent of all psychiatric disorders and is the single most burdensome disease worldwide. In attempting to understand the profound deficits that characterize MDD across multiple domains of functioning, researchers have identified aberrations in brain structure and function in individuals diagnosed with this disorder. In this review we synthesize recent data from human neuroimaging studies in presenting an integrated neural network framework for understanding the impairments experienced by individuals with MDD. We discuss the implications of these findings for assessment of and intervention for MDD. We conclude by offering directions for future research that we believe will advance our understanding of neural factors that contribute to the etiology and course of depression, and to recovery from this debilitating disorder.

show abstract

Brain circuitries involved in emotional interference task in major depression disorder

Cited by 52 publications

References 27 publications

Early life stress predicts thalamic hyperconnectivity: A transdiagnostic study of global connectivity

Early life stress predicts thalamic hyperconnectivity: A transdiagnostic study of global connectivity

Social cognition in major depressive disorder: A new paradigm?

The neuroscience of depression: Implications for assessment and intervention

Contact Info

Product

Resources

About