Brain core temperature of patients with mild traumatic brain injury as assessed by DWI-thermometry

Abstract

IntroductionThe aim of this study was to assess the brain core temperature of patients with mild traumatic brain injury (mTBI) using a noninvasive temperature measurement technique based on the diffusion coefficient of the cerebrospinal fluid.MethodsThis retrospective study used the data collected from April 2008 to June 2011. The patient group comprised 20 patients with a Glasgow Coma Scale score of 14 or 15 who underwent magnetic resonance imaging within 30 days after head trauma. The normal control group comprised 14 subjects who volunteered for a brain checkup (known in Japan as “brain dock”). We compared lateral ventricular (LV) temperature between patient and control groups. Follow-up studies were performed for four patients.ResultsLV temperature measurements were successfully performed for both patients and controls. Mean (±standard deviation) measured LV temperature was 36.9 ± 1.5 °C in patients, 38.7 ± 1.8 °C in follow-ups, and 37.9 ± 1.2 °C in controls, showing a significant difference between patients and controls (P = 0.017). However, no significant difference was evident between patients and follow-ups (P = 0.595) or between follow-ups and controls (P = 0.465).ConclusionsA reduction in brain core temperature was observed in patients with mTBI, possibly due to a global decrease in metabolism.

Biological Aging and Life Span Based on Entropy Stress via Organ and Mitochondrial Metabolic Loading

“…With assumption of 55:30:15, CH:F:P (mass %), the energy release % is computed as 36.1%, 49.5% and 14.4% via CH, F and P [9] and hence η Met = 0.361 × 38.2 + 0.495 × 32.2 + 0.144 × 0.104 = 0.31. Salin et al [41] reports that there is variation of P/O ratio within an individual and amongst individuals due to diet, temperature and environmental factors. The current work presumes that it is affected only by diet, i.e., composition % of CH:F:P metabolized.…”

Automated temperature calculation method for DWI-thermometry: The usefulness of LV probability map on healthy subjects

“…Previous papers [1][2][3][4][5][6] have employed manual extraction of the LV area. The method proposed in this paper allows the user to automatically extract the effective CSF region for DWI thermometry.…”

“…This method has already been applied for measuring deep brain temperature in healthy volunteers [1], for determining the relationship between tympanic temperature and deep brain temperature [2], the age-dependence of deep brain temperature in healthy volunteers [3], and applications for Moya moya disease [4] ,head trauma [5], and idiopathic normal pressure hydrocephalus [6].…”

How does the protein content of CSF affect for DWI thermometry?: Initial results of phantom and subarachnoid hemorrhage patient study

“…Although only applicable to non-restricted water, e.g., cerebrospinal fluid (CSF), it is potentially useful in assessing the thermal pathophysiology of the brain in both patients and healthy subjects. This method has already been applied for measuring deep brain temperature in healthy volunteers [3], for determining the relationship between tympanic temperature and deep brain temperature [4], the age-dependence of deep brain temperature in healthy volunteers [5], and applications for Moya moya disease [6] ,head trauma [7], idiopathic normal pressure hydrocephalus [8], and for assessing of multiple sclerosis patients [9].…”

“…We have also experienced temperature decline with DWI thermometry in the case of head trauma [7]. In normal adults, the CSF protein concentration is the range of 0.18 to 0.58 mg/ml [11].…”