Brain–heart communication in health and diseases

Liu, Wei; Zhang, Xinying; Wu, Zifeng; Huang, Kai; Yang, Chun; Yang, Ling

doi:10.1016/j.brainresbull.2022.02.012

Cited by 21 publications

(15 citation statements)

References 156 publications

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“…Since the heart is endowed with a high density of Cx43 controlling conduction velocity [ 32 ], one could expect that the systemic administration of CBX may also inhibit Cx43 in the heart, causing low cardiac output, brain hypoperfusion and subsequent abnormal functions, such as the development of depressive behavior [ 33 ]. The latter hypothesis is supported by epidemiological data showing that patients with cardiovascular diseases are more likely to be depressed [ 31 ] and possibly display poorer treatment response, as reported here.…”

Section: Discussionsupporting

confidence: 85%

“…Beyond these considerations, it is now well accepted that the heart and the brain have tight anatomical and functional interaction connections. In particular, through the neuroendocrine–heart axis and the neuroimmune–heart axis, the brain maintains physiological homeostasis of the cardiovascular system, which in turn controls brain blood flow [ 31 ]. Since the heart is endowed with a high density of Cx43 controlling conduction velocity [ 32 ], one could expect that the systemic administration of CBX may also inhibit Cx43 in the heart, causing low cardiac output, brain hypoperfusion and subsequent abnormal functions, such as the development of depressive behavior [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

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Astroglial Connexins Inactivation Increases Relapse of Depressive-like Phenotype after Antidepressant Withdrawal

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Vasile

Zapata

et al. 2022

IJMS

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Studies suggest that astrocytic connexins (Cx) have an important role in the regulation of high brain functions through their ability to establish fine-tuned communication with neurons within the tripartite synapse. In light of these properties, growing evidence suggests a role of Cx in psychiatric disorders such as major depression but also in the therapeutic activity of antidepressant drugs. However, the real impact of Cx on treatment response and the underlying neurobiological mechanisms remain yet to be clarified. On this ground, the present study was designed to evaluate the functional activity of Cx in a mouse model of depression based on chronic corticosterone exposure and to determine to which extent their pharmacological inactivation influences the antidepressant-like activity of venlafaxine (VENLA). On the one hand, our results indicate that depressed mice have impaired Cx-based gap-junction and hemichannel activities. On the other hand, while VENLA exerts robust antidepressant-like activity in depressed mice; this effect is abolished by the pharmacological inhibition of Cx with carbenoxolone (CBX). Interestingly, the combination of VENLA and CBX is also associated with a higher rate of relapse after treatment withdrawal. To our knowledge, this study is one of the first to develop a model of relapse, and our results reveal that Cx-mediated dynamic neuroglial interactions play a critical role in the efficacy of monoaminergic antidepressant drugs, thus providing new targets for the treatment of depression.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Astroglial Connexins Inactivation Increases Relapse of Depressive-like Phenotype after Antidepressant Withdrawal

Portal

Vasile

Zapata

et al. 2022

IJMS

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“…The autonomic nervous system plays an important role in the physiological function of the cardiovascular system. An imbalance in autonomic tone is a critical pathophysiological mechanism in the development of cardiovascular disorders [ 1 , 2 ]. The roles of excessive activated sympathetic tone in hypertension, heart failure, and tachyarrhythmias have been systematically investigated and understood [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…An imbalance in autonomic tone is a critical pathophysiological mechanism in the development of cardiovascular disorders [ 1 , 2 ]. The roles of excessive activated sympathetic tone in hypertension, heart failure, and tachyarrhythmias have been systematically investigated and understood [ 1 , 2 ]. Nonetheless, the knowledge about and therapeutic strategies for the treatment of vagal tone-associated cardiovascular disorders are still limited.…”

Section: Introductionmentioning

confidence: 99%

Extracardiac Vagal Stimulation-Assisted Cardioneuroablation: Dynamically Evaluating the Impact of Sequential Ganglionated Plexus Ablation on Vagal Control of SAN and AVN in Patients with Sinoatrial Node Dysfunction

Chen

Liu

Xiao

et al. 2022

JCDD

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Cardioneuroablation (CNA) is proposed as a promising therapy for patients with sinoatrial node dysfunction (SND) that is mediated by excessive vagal tone. However, a series of urgent questions about CNA remain unanswered. From December 2020 to March 2022, six patients with symptomatic SND who underwent CNA were summarized in this report. Sequential CNA targeting Ao-SVC GP, PMLGP, RAGP, and LSGP was performed in patients, guided by fractionated intracardiac electrograms and dynamically evaluated by extracardiac vagal stimulation (ECVS). The results showed that Ao-SVC GP ablation led to a significant increase in heart rate (HR) and the elimination of sinus arrest evoked by ECVS, while the vagal responses of atrial ventricular block were eliminated by the ablation of PMLGP and LSGP. Post-procedure HR increased up to 64–86% of the maximum HR of an atropine test at baseline. The median HR from Holter monitoring increased from 52.8 ± 2.1 bpm at baseline to 73.0 ± 10.4 bpm after the procedure (p = 0.012) and to 71.3 ± 10.1 bpm at the six-month follow-up (p = 0.011). Bradycardia-related symptoms disappeared in all patients at the six-month follow-up. This case series reveals the feasibility of using the ECVS-assisted sequential CNA technique and indicates the critical role of ECVS in dynamically evaluating the impact of sequential CNA on the vagal control of SAN and AVN.

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“…The concept of the brain-heart pathway has been proposed by several recent studies (1,2). The identification of dynamic and ongoing neural communication pathways between the heart and brain has elucidated the influence of the brain on cardiovascular responses in different conditions (3).…”

Section: Introductionmentioning

confidence: 99%

Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people: A randomized cross-controlled trial

Chen

Lü

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveTo investigate whether anodal high-definition transcranial current stimulation (HD-tDCS) over the left dorsolateral pre-frontal cortex (DLPFC) could modulate the heart rate (HR) and heart-rate variability (HRV) in healthy young people.MethodsForty healthy young people were enrolled in this randomized crossover trial. The participants were randomized to receive anodal HD-tDCS (n = 20) or sham HD-tDCS (n = 20) over the left DLPFC with a washout period of 1 week. Electrocardiogram (ECG) data were continuously recorded 20 min before the stimulation, during the session (20 min), and 20 min after the session. HR and the time- and frequency-domain indices of the HRV were measured to investigate the activity of the sympathetic and parasympathetic nervous systems.ResultsAnodal HD-tDCS over the left DLPFC induced a significant decrease in HR and a significant increase in the average of normal-to-normal intervals (AVG NN), low-frequency (LF) power, total power (TP), and LF/high-frequency (HF) ratio in comparison with the sham stimulation and the baseline. However, sham HD-tDCS over the left DLPFC had no significant effect on HR or HRV.ConclusionsAnodal HD-tDCS over the left DLPFC could reduce HR and modulate the HRV in healthy young people. HD-tDCS may show some potential for acutely modulating cardiovascular function.

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Brain–heart communication in health and diseases

Cited by 21 publications

References 156 publications

Astroglial Connexins Inactivation Increases Relapse of Depressive-like Phenotype after Antidepressant Withdrawal

Astroglial Connexins Inactivation Increases Relapse of Depressive-like Phenotype after Antidepressant Withdrawal

Extracardiac Vagal Stimulation-Assisted Cardioneuroablation: Dynamically Evaluating the Impact of Sequential Ganglionated Plexus Ablation on Vagal Control of SAN and AVN in Patients with Sinoatrial Node Dysfunction

Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people: A randomized cross-controlled trial

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