Brain Imaging Studies of Depressive Disorders

Sackeïm, Harold A.; Prohovnik, Isak

doi:10.1007/978-1-4757-9498-4_10

Cited by 20 publications

(8 citation statements)

References 159 publications

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Section: Discussionmentioning

confidence: 98%

“…Single-photon emission computerized tomography (ie, SPECT) data reported by Sackeim and Prohovnik,17 suggesting that the frontal lobes might be the site in which ECT exerts its main therapeutic effects, serve to offer a theoretical explanation for the efficacy of the BF placement. 17 Another possible factor to assess cognitive risk/benefit ratio is stimulus dose. Heikman et al 12 reported that high-dose (5X ST) RUL ECT has a faster antidepressant effect than low-dose (1.0X ST) BF ECT and recommended further studies to assess cognitive risk/benefit ratio of a higher BF stimulus dose (at least 1.5X ST).…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Bifrontal Versus Right Unilateral and Bitemporal Electroconvulsive Therapy in Major Depressive Disorder

Ranjkesh¹,

Barekatain²,

Akuchakian³

2005

The Journal of ECT

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Bifrontal Versus Right Unilateral and Bitemporal Electroconvulsive Therapy in Major Depressive Disorder

Ranjkesh¹,

Barekatain²,

Akuchakian³

2005

The Journal of ECT

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“…Usando esta técnica, a maioria dos estudos constatou uma redução global no fluxo sangüíneo cortical na depressão maior, principalmente nas regiões frontais. [33][34][35] 2. Tomografia por emissão de pósitrons (PET) Dois estudos iniciais realizados na Califórnia usando PET documentaram taxas relativamente baixas de metabolização da glicose nos lobos frontais e nos gânglios da base de pacientes deprimidos, quando comparados a controles normais.…”

Section: Tomografia Por Emissão De Fóton úNico (Spect)unclassified

Genética e fisiopatologia dos transtornos depressivos

Lafer

Filho

1999

Rev. Bras. Psiquiatr.

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Fatores genéticos, neurobiológicos e ambientais participam da gênese das depressões. Esta breve revisão visa enfatizar os estudos sobre os aspectos genéticos, neuroquímicos e neuroanatômicos na etiologia e fisiopatologia das depressões e suas implicações no desenvolvimento de novos tratamentos. Procura-se enfatizar as limitações encontradas até o momento na tentativa do estabelecimento de uma etiopatogenia comum às depressões, principalmente em função da dificuldade no diagnóstico e da heterogeneidade na fenomenologia do episódio agudo e no curso longitudinal. Perspectivas para futuras pesquisas também são apresentadas.
Genetic, neurobiological and environmental factors play a role in the pathogenesis of depressive disorders. This brief review points to the major studies on the genetics, neurochemistry and neuroanatomy of depressive disorders as well as their implications on the development of new treatments. The limitations found by several groups in establishing a common etiopathogenesis are emphasised in light of the difficulty in establishing a reliable diagnosis and of the clinical heterogeneity found in the phenomenology of acute episodes and long-term outcome. Future research perspectives are also presented

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“…16 Thus, high-frequency stimulation over frontal cortex leads to cordance increase in theta for responders contrary to low-frequency responders. 10 Teneback et al 31 have found that responders to highfrequency rTMS are characterized by increased metabolic activity in frontal regions. One of the baseline neurophysiological biomarkers for poor treatment outcome for depression is decreased metabolic activity in frontal regions.…”

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confidence: 99%

Analysis of Brain Functional Changes in High-Frequency Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression

et al. 2014

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Repetitive transcranial magnetic stimulation (rTMS) is a treatment procedure that uses magnetic fields to stimulate nerve cells in the brain, and is associated with significant improvements in clinical symptoms of major depressive disorder (MDD). The effect of rTMS treatment on the brain can be evaluated by cordance, a quantitative electroencephalography (QEEG) method that extracts information from absolute and relative power of EEG spectra. In this study, to analyze brain functional changes, pre- and post-rTMS, QEEG data were collected from 6 frontal electrodes (Fp1, Fp2, F3, F4, F7, and F8) in 2 slow bands (delta and theta) for 55 MDD subjects. To examine brain changes, cordance scores were determined, using repeated-measures analysis of variance (ANOVA). High-frequency rTMS was associated with cordance decrease in left frontal and right prefrontal regions in both delta and theta for nonresponders; it was associated with cordance increase in all right and left frontal electrodes, except F8, for responders.

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Brain Imaging Studies of Depressive Disorders

Cited by 20 publications

References 159 publications

Bifrontal Versus Right Unilateral and Bitemporal Electroconvulsive Therapy in Major Depressive Disorder

Bifrontal Versus Right Unilateral and Bitemporal Electroconvulsive Therapy in Major Depressive Disorder

Genética e fisiopatologia dos transtornos depressivos

Analysis of Brain Functional Changes in High-Frequency Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression

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