2012
DOI: 10.1039/c2cs35146c
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Branched and linear poly(ethylene imine)-based conjugates: synthetic modification, characterization, and application

Abstract: Poly(ethylene imine)s (PEIs) are widely used in different applications, but most extensively investigated as non-viral vector systems. The high ability of cationic PEIs to complex and condense negatively charged DNA and RNA combined with their inherent proton sponge behavior accounts for the excellent efficiency in gene delivery. Further chemical modifications of the polymer expand the application potential, primarily aiming at increased transfection efficiency, cell selectivity and reduced cytotoxicity. Impro… Show more

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Cited by 288 publications
(228 citation statements)
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References 130 publications
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“…In particular potential usage in mammalian bodies and/or sanitary applications greatly benefits from the control of the cationic ring-opening polymerization CROP and the regioselective initiation. The hydrolysis of poly(2-oxazoline)s yields poly(ethylene imine)s (Scheme 1), which opens a whole new area of synthetic strategies for (polymeranalogous) polymer modification, even further expanding the "toolbox" of chemical findings for fine-tuning the poly(2-oxazoline)-based materials with numerous potential applications in the biomedical sector [7][8][9]. Scheme 1.…”
Section: Introductionmentioning
confidence: 99%
“…In particular potential usage in mammalian bodies and/or sanitary applications greatly benefits from the control of the cationic ring-opening polymerization CROP and the regioselective initiation. The hydrolysis of poly(2-oxazoline)s yields poly(ethylene imine)s (Scheme 1), which opens a whole new area of synthetic strategies for (polymeranalogous) polymer modification, even further expanding the "toolbox" of chemical findings for fine-tuning the poly(2-oxazoline)-based materials with numerous potential applications in the biomedical sector [7][8][9]. Scheme 1.…”
Section: Introductionmentioning
confidence: 99%
“…[5][6][7][8] Upon a change of environment such as pH, temperature, or light 9 they undergo a modification in their structure or disassemble into smaller parts. Prominent examples of pH sensitive materials are peptides with chargeable groups or polymers such as poly(acrylic acid) (PAA), 10 poly(ethylene imine) (PEI) 11 or poly(dimethylamino ethylmethacrylate) (pDMAEMA), 12 which can be reversibly protonated or deprotonated with changes of pH. The resulting variation in charge density can be utilized to control solubility in aqueous media and/or electrostatic repulsion, which can affect the integrity of selfassembled structures such as polymer micelles or vesicles, 13 thereby allowing effective loading and release of drugs encapsulated within these nanostructures.…”
mentioning
confidence: 99%
“…7,20 In fact, 18 they can arguably compete or even outperform the gold standards of the field, namely 19 poly(ethylene glycol) and poly(N-hydroxypropylmethacrylamide). [21][22][23][24] For use of PAOx in 20 biomedical applications, it is important to have easy and straightforward functionalization 21 methodologies, either for conjugation of the polymers to biological media or substrates or to 22 attach drug molecules, labels or targeting moieties. Up to three orthogonal functionalities can be 23 …”
mentioning
confidence: 99%