BRCA-1 promoter hypermethylation and silencing induced by the aromatic hydrocarbon receptor-ligand TCDD are prevented by resveratrol in MCF-7 Cells

Papoutsis, Andreas; Borg, Jamie; Selmin, Ornella I.; Romagnolo, Donato F.

doi:10.1016/j.jnutbio.2011.08.001

Cited by 68 publications

(62 citation statements)

References 53 publications

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“…3 In the current study, our analysis did not show significant relationship between radiation/chemotherapy and OS and DFS, which could be for 2 reasons. First, for radiation therapy, in other research studies, 35,36 which showed that radiation therapy had a positive effect on patients' survival, almost every patient received postoperative radiation therapy, but in our cohort, only 77.3% (51 of 66) received postoperative radiation therapy. Second, for the chemotherapy, in the current study, only 19.7% (13 of 66) of patients underwent postoperative treatment.…”

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confidence: 59%

“…Abbreviations: CI, confidence interval; CT, chemotherapy; c/t, cribriform/ tubular pattern; HRs, hazard ratios; n, negative; H3K9Ac, histone H3 lysine 9 acetylation; H3K9me3, histone H3 lysine 9 trimethylation; p, positive; RT, radiation therapy; s, solid pattern. can regulate the expression of certain tumor suppressor genes, such as p16, RIZ1, 14 and BRCA1, 35 which leads to the inhibition of tumor cell apoptosis. In addition, histone modifications can also regulate tumor suppressor genes that are associated with cell proliferation and distant metastasis, as described above.…”

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confidence: 99%

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High Expression of H3K9me3 Is a Strong Predictor of Poor Survival in Patients With Salivary Adenoid Cystic Carcinoma

Xia

Zhou

Tian

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Histone methylation and acetylation play important roles in the carcinogenesis and progression of cancer. Objective.—To investigate whether histone modifications influence the prognosis of patients with salivary adenoid cystic carcinoma (ACC). Design.—The expression of histone H3 lysine 9 trimethylation (H3K9me3) and histone H3 lysine 9 acetylation (H3K9Ac) was assessed by immunohistochemistry in 66 specimens of primary ACC. Tests were used to determine the presence of any correlation between H3K9me3 and H3K9Ac levels and clinicopathologic parameters. Log-rank test and Cox proportional hazards regression models were used to analyze the survival data. Results.—H3K9me3 expression was positively correlated with solid pattern tumors (P = .002) and distant metastasis (P = .001). Solid pattern tumors had lower H3K9Ac expression levels than cribriform-tubular pattern tumors (P = .03). Patients whose tumors showed high H3K9me3 expression and a solid pattern had a significantly poorer overall survival (OS) (P < .001 and P < .001, respectively) and disease-free survival (P < .001 and P = .01, respectively). Low H3K9Ac expression was correlated with poor OS (P = .05). The multivariate analysis indicated that high levels of H3K9me3 expression and solid pattern tumors were independent prognostic factors that significantly influenced OS (P = .004 and P = .04, respectively). H3K9me3 expression was identified as the only independent predictor of disease-free survival (P = .006). Conclusions.—Our results suggest that high levels of H3K9me3 expression are predictive of rapid cell proliferation and distant metastasis in ACC. Compared with histologic patterns, H3K9me3 might be a better predictive biomarker for the prognosis of patients with salivary ACC.

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confidence: 59%

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confidence: 99%

High Expression of H3K9me3 Is a Strong Predictor of Poor Survival in Patients With Salivary Adenoid Cystic Carcinoma

Xia

Zhou

Tian

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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“…This leads to upregulation of manganese superoxide dismutase (MnSOD) and catalase, major components of the cellular antioxidant defense system (168). In addition to these epigenetic effects, several reports have demonstrated that resveratrol through interacting with DNMT1 prevents hypermethylation or induces demethylation in hypermethylated tumor suppressor genes (169)(170)(171)(172).…”

Section: Inhibition Of Hdacs By Bioactive Food Constituents and Prevementioning

confidence: 99%

Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents

Moreno

Heidor

Pogribny

2016

Nutrition and Cancer

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Hepatocellular carcinoma (HCC) is an aggressive and life-threatening disease often diagnosed at intermediate or advanced stages, which substantially limits therapeutic approaches to its successful treatment. This indicates that the prevention of HCC may be the most promising strategy in reducing its incidence and mortality. Emerging evidence indicates that numerous nutrients and nonnutrient dietary bioactive components can reduce the occurrence and/or delay the development of HCC through modifications of deregulated epigenetic mechanisms. This review examines the existing knowledge on the epigenetic mechanism-based studies in in vitro and in vivo models of HCC on the chemopreventive potential of epigenetic food components, including dietary methyl-group donors, epigallocatechin-3-gallate, sodium butyrate, resveratrol, curcumin, and sulforaphane, on liver carcinogenesis. Future direction and potential challenges in the effective use of bioactive food constituents in the prevention of HCC are highlighted and discussed.

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“…It was shown that exposure to RES led to demethylation and re-expression of RARβ2 and PTEN tumor suppressor genes with a concomitant decrease in DNMT1 expression and upregulation of p21, in non-invasive MCF-7 breast cancer cells [99]. RES prevented BRCA1 promoter hypermethylation and silencing induced by an aromatic hydrocarbon receptor ligand in MCF-7 cells [100].…”

Section: Natural Dnmt Inhibitors In Other Carcinomasmentioning

confidence: 99%

Natural Compounds: DNA Methyltransferase Inhibitors in Oral Squamous Cell Carcinoma

Jha

Aggarwal

Jha

et al. 2015

Appl Biochem Biotechnol

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Oral squamous cell carcinoma (OSCC) is a multistep process which is modulated by several endogenous and environmental factors. Epigenetic changes have been found to be equally responsible for OSCC as genetic changes. A plethora of genes showing hypermethylation have been discovered in OSCC. Since these changes are reversible, a lot of emphasis is on using the natural compounds for their ability to cause demethylation which could lead to reactivation of the inactivated tumor suppressor genes. This review encompasses the promoter hypermethylation of tumor suppressor genes in OSCC and its possible reversal using natural compounds. In addition, new compounds which could be screened for their demethylating ability have also been proposed.

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BRCA-1 promoter hypermethylation and silencing induced by the aromatic hydrocarbon receptor-ligand TCDD are prevented by resveratrol in MCF-7 Cells

Cited by 68 publications

References 53 publications

High Expression of H3K9me3 Is a Strong Predictor of Poor Survival in Patients With Salivary Adenoid Cystic Carcinoma

High Expression of H3K9me3 Is a Strong Predictor of Poor Survival in Patients With Salivary Adenoid Cystic Carcinoma

Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents

Natural Compounds: DNA Methyltransferase Inhibitors in Oral Squamous Cell Carcinoma

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