Breast Cancer Survival in Germany: A Population-Based High Resolution Study from Saarland

Abstract

Population-based survival studies of breast cancer patients are commonly restricted to age- and stage-specific analyses. This study from Germany aimed at extending available population-based survival data on further prognostic cancer characteristics such as tumor grade, hormone receptor status and human epidermal growth factor receptor type 2 (HER2/neu) expression. Data from the population-based Saarland Cancer Registry including female patients diagnosed with invasive breast cancer between 2000 and 2009 were included. Period analysis methodology and regression modelling were used to obtain estimates of 5-year relative survival and tumor related excess risks in 2005-2009. Overall age standardized 5-year relative survival was 83%. In addition to age and stage, tumor grade and hormone receptor status were independent predictors of 5-year relative survival. Detailed analyses by age, stage, morphology, tumor grade, hormone receptor status and HER2/neu expression consistently revealed lower survival of patients with high grade, hormone receptor negative or HER2/neu positive cancers and patients aged 70 years or older. This high resolution study extends available population-based survival data of breast cancer patients. Particular efforts should be made to overcome the persisting large survival deficits, which were observed for elderly patients in all clinical subgroups.

Survival status and predictors of mortality among Breast Cancer patients in Adult Oncology Unit at Black Lion Specialized Hospital, Addis Ababa, Ethiopia, 2018

“…Women who had clinical stage (III and IV) at diagnosis were nearly 2 times higher risk of death as compared to women who had clinical stage (I$II) at time of diagnosis. This finding is in agreement with several studies conducted in different Africa and Asian countries (4,26,28,34). Stage is an important predictor of survival from breast cancer, and the most significant influence on patient outcome in the present study.…”

“…In this 6-year retrospective follow up study, the overall survival rates at 1, 3, and 5 years were, 97.2%, 80.8%, and 46.2% respectively. This finding is consistent with other previous studies which have been conducted in Malaysia (70.8%, 56.9% and 49.4%) (23) and Ghana, (47.9%) (17) .However, this finding is higher than those in other African countries in Tanzania (21.8%) (24) and Cameroon (30%) (25) at 5 years and even lower than previous results in Uganda (51.8 %) (26), and Vietnam, (94%, 83% and 74%)(4).This ,figure is still lower when compared with that of studies of high income countries such as Northwest Iran (96%, 86%, and 81%), Germany( 83% ),and the Qidong(83.61%,67.53%,and58.75%)respectively (27)(28)(29).…”

Sitotoksisitas Ekstrak Aseton Dan Kandungan Fukosantin Rumput Laut Sargassum

“…Kanker payudara dan serviks merupakan kanker yang memiliki keganasan yang tinggi. Kanker payudara merupakan kanker yang paling sering terjadi pada wanita diikuti oleh kanker serviks (Parkin et al, 2005;Holleczek et al, 2013).…”

“…Kanker payudara dan serviks merupakan kanker yang memiliki keganasan yang tinggi. Kanker payudara merupakan kanker yang paling sering terjadi pada wanita diikuti oleh kanker serviks (Parkin et al, 2005;Holleczek et al, 2013).Banyak usaha yang dilakukan untuk mencari obatobatan antikanker, salah satunya adalah dengan mengeksplorasi senyawa bioaktif dari bahan alam yang berasal dari lingkungan laut (marine natural …”

Isolasi Fukosantin dari Rumput Laut Coklat Padina australis dan Sitotoksisitasnya terhadap Sel MCF7 dan Sel Vero

“…Penyakit kanker yang paling sering terjadi pada wanita adalah kanker payudara diikuti oleh kanker serviks (Holleczek, Jensen, & Brenner, 2013;Parkin, Bray, Ferlay, & Pisani, 2005). Upaya untuk mengobati dan mencegah kanker payudara masih terus dilakukan.…”