Breast hamartomas

Linell, F; Ostberg, G; Söderström, Jan; Andersson, Ingvar; Hildell, J; Ljungqvist, U

doi:10.1007/bf00430244

Cited by 54 publications

(14 citation statements)

References 3 publications

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“…Although there are no data regarding the tumor recurrence rate, reported cases of tumor recurrence are very rare with only one case having been reported by Linell et al (9). Our patient experienced recurrence is 12 months.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Recurrent Myoid Hamartoma Mimicking Malignancy: Imaging Appearances

Jung

Suk

et al. 2010

Korean J Radiol

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Myoid hamartoma is an uncommon type of breast hamartoma and its recurrence is very rare. We report the imaging appearance of an unusual case of recurrent myoid hamartoma of the breast mimicking malignancy in a 43-year-old woman. Although the mammographic and ultrasonographic findings have long been described in the literature, MR finding with a dynamic study has not, to the best of our knowledge, been reported previously.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Recurrent Myoid Hamartoma Mimicking Malignancy: Imaging Appearances

Jung

Suk

et al. 2010

Korean J Radiol

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“…16,17 In our study, the median age was 40 years, which is comparable to the literature. 5,18,19 Clinically, breast hamartomas are usually diagnosed during routine screening or because they are symptomatic (painless soft to firm lumps 5,11,13,20 and rarely painful 19 ). They are more often single, but cases of multiple hamartomas have been described, 13,21,22 as in two of our 45 patients.…”

Section: Discussionmentioning

confidence: 99%

“…This leads to repeated biopsies, especially if clinical and imaging features are not taken into account. This lack of a specific appearance probably leads to an underestimated incidence 5,10,11 and diagnostic delay. Thus, close interaction between radiologists and pathologists appears to be primordial for an accurate diagnostic approach for breast hamartomas.…”

Section: Introductionmentioning

confidence: 99%

Breast hamartoma: reassessment of an under‐recognised breast lesion

Alran

Chamming’s²,

Auriol-Leizagoyen³

et al. 2021

Histopathology

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Breast hamartoma: reassessment of an under-recognised breast lesionAims: Breast hamartomas are an under-recognised lesion because they lack a distinctive microscopic appearance. Microscopic diagnosis can often conclude 'no significant lesion' or 'normal breast tissue', leading to repeated biopsies and diagnostic delay. We describe the histological, immunohistochemical and radiological features of breast hamartomas with the aim of identifying specific signs to facilitate their diagnosis and to differentiate them from normal breast and fibroepithelial lesions. Methods and results: Forty-seven breast hamartomas were reassessed (histological diagnosis and imaging features). An immunohistochemical study [oestrogen receptor (ER), progesterone receptor (PR), CD34, high-mobility group A2 (HMGA2)] was performed. On breast imaging, hamartomas most often presented as probably benign solid masses with circumscribed margins and variable densities. Histologically, breast hamartomas resembled normal breast, although their stromal component was predominant, separating randomly scattered epithelial elements with areas of pure collagenous stroma. Pseudoangiomatous stromal hyperplasia (PASH) was present in 93.6% of cases and CD34 antibody highlighted intralobular, perilobular and interlobular distribution of CD34-positive fibroblasts. By comparison, CD34 was mainly expressed in the intralobular normal breast tissue stroma. Hamartoma stromal cells expressed HMGA2, ER and PR in 79%, 66% and 76.3% of our cases, respectively, compared to 7.7%, 23% and 19% in normal breast tissue, respectively (P < 0.0001; P = 0.0005; P < 0.0001). Conclusions: After ascertaining that core needle biopsy is effectively intralesional, breast hamartomas can be diagnosed with confidence by taking into account the presence of stromal changes, PASH, interlobular distribution of CD34-positive fibroblasts, HMGA2 and hormonal receptor stromal expression.

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“…They usually present at 45 years of age as a painless mass approximately 5 cm in diameter. They may reach a considerable size, the largest reported being 18 cms in diameter and weighing 1400 grams 3 . They occur unilaterally and never recur after excision.…”

Section: Discussionmentioning

confidence: 99%

An Uncommon Benign Breast Tumour – Hamartoma

Thirumavalavan¹,

Rufaie²

1993

Int J Clinical Practice

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SUMMARYTwo patients who presented with mobile breast lumps which were later diagnosed to be hamartomas are presented, along with a brief review of current literature. These benign lesions are likely to be increasingly diagnosed because of routine mammographic screening and hence clinical awareness is paramount to prevent these lesions from being overtreated.Hamartoma of the breast is a rare benign breast lesion which is unfamiliar to most clinicians. We herein report two examples of such a lesion and review the recent literature. The hamartoma presents as a soft well‐defined lump, causing considerable asymmetry of the breasts.

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Breast hamartomas

Cited by 54 publications

References 3 publications

A Rare Case of Recurrent Myoid Hamartoma Mimicking Malignancy: Imaging Appearances

A Rare Case of Recurrent Myoid Hamartoma Mimicking Malignancy: Imaging Appearances

Breast hamartoma: reassessment of an under‐recognised breast lesion

An Uncommon Benign Breast Tumour – Hamartoma

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