Breast tumor hemodynamic response during a breath-hold as a biomarker to predict chemotherapeutic efficacy: preclinical study

Lee, Songhyun; Kim, Jae Gwan

doi:10.1117/1.jbo.23.4.048001

Cited by 3 publications

(6 citation statements)

References 22 publications

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“…In this study, the average SpO 2 changed from 98.6% to 94.4% as the supplied gas was changed from 50% O 2 gas balanced by N 2 gas to 16% O 2 gas balanced by N 2 gas. While the drop of SpO 2 in this study was smaller (98.6% → 94.4%: 4.2% difference) than the one of the previous study (97% → 91%: 6% difference) [ 28 ], the drop of SpO 2 , which is observed in a human study during breath-holding [ 63 ], guarantees that the protocol used in this study can mimic breath-holding as well. At the same time, 94.4% SpO 2 can assure the safety of the animal because this value is higher than the one (92% SpO 2 ) of people living in Aspen, Colorado where people do not have any critical health issues [ 28 ].…”

Section: Discussionmentioning

confidence: 55%

“…Since animals cannot perform breath-holding spontaneously, the hypoxic respiratory challenge was used to mimic breath-holding even though hypoxic respiratory challenge may not be able to mimic breath-holding perfectly. The experimental protocol used in the work (50% O 2 gas balanced by N 2 gas for 10 min → 16% O 2 gas balanced by N 2 gas for 5 min as hypoxic gas challenge → 50% O 2 gas balanced by N 2 gas for 15 min) was based on a protocol used in a previous breast cancer study by S. Lee and J. G. Kim (100% O 2 gas for 3 min → 21% O 2 gas balanced by N 2 gas for 10 min as the hypoxic gas challenge) with a minute modification [ 28 ]. In the previous study, the average pulmonary oxygen saturation (SpO 2 ) of rats changed from 97% to 91% as the supplied gas was changed from 100% O 2 gas to 21% O 2 gas balanced by N 2 gas.…”

Section: Discussionmentioning

confidence: 99%

“…The unit of hemoglobin concentration was set to be mM/DPF, which is equivalent to setting DPF as 1 at different wavelengths [ 24 ]. Note that considering DPF as a part of the unit of hemoglobin concentration is one of the widely accepted approaches [ 12 , 24 , 25 , 28 ]. In this study, 808 nm was selected because it is known as one of the isosbestic points of the extinction coefficients of

and

[ 29 ].…”

Section: Methodsmentioning

confidence: 99%

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Use of Hypoxic Respiratory Challenge for Differentiating Alzheimer’s Disease and Wild-Type Mice Non-Invasively: A Diffuse Optical Spectroscopy Study

Seong

Park

et al. 2022

Biosensors

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Alzheimer’s disease is one of the most critical brain diseases. The prevalence of the disease keeps rising due to increasing life spans. This study aims to examine the use of hemodynamic signals during hypoxic respiratory challenge for the differentiation of Alzheimer’s disease (AD) and wild-type (WT) mice. Diffuse optical spectroscopy, an optical system that can non-invasively monitor transient changes in deoxygenated () and oxygenated () hemoglobin concentrations, was used to monitor hemodynamic reactivity during hypoxic respiratory challenges in an animal model. From the acquired signals, 13 hemodynamic features were extracted from each of and (26 features total) for more in-depth analyses of the differences between AD and WT. The hemodynamic features were statistically analyzed and tested to explore the possibility of using machine learning (ML) to differentiate AD and WT. Among the twenty-six features, two features of and one feature of showed statistically significant differences between AD and WT. Among ML techniques, a naive Bayes algorithm achieved the best of 84.3% when whole hemodynamic features were used for differentiation. While further works are required to improve the approach, the suggested approach has the potential to be an alternative method for the differentiation of AD and WT.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

and

[ 29 ].…”

Section: Methodsmentioning

confidence: 99%

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Use of Hypoxic Respiratory Challenge for Differentiating Alzheimer’s Disease and Wild-Type Mice Non-Invasively: A Diffuse Optical Spectroscopy Study

Seong

Park

et al. 2022

Biosensors

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“… 16 A preclinical study of a rat breast cancer model yielded results consistent with these findings, demonstrating that changes in

during simulated breath holds could differentiate treatment and control groups and that optical changes preceded tumor volume changes. 50 Another clinical study demonstrated that compression-induced hemodynamics were able to differentiate responders from nonresponders within the first month of chemotherapy. 51 …”

Section: Discussionmentioning

confidence: 99%

High optode-density wearable diffuse optical probe for monitoring paced breathing hemodynamics in breast tissue

et al. 2021

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. Significance: Diffuse optical imaging (DOI) provides in vivo quantification of tissue chromophores such as oxy- and deoxyhemoglobin ( and HHb, respectively). These parameters have been shown to be useful for predicting neoadjuvant treatment response in breast cancer patients. However, most DOI devices designed for the breast are nonportable, making frequent longitudinal monitoring during treatment a challenge. Furthermore, hemodynamics related to the respiratory cycle are currently unexplored in the breast and may have prognostic value. Aim: To design, fabricate, and validate a high optode-density wearable continuous wave diffuse optical probe for the monitoring of breathing hemodynamics in breast tissue. Approach: The probe has a rigid-flex design with 16 dual-wavelength sources and 16 detectors. Performance was characterized on tissue-simulating phantoms, and validation was performed through flow phantom and cuff occlusion measurements. The breasts of healthy volunteers were measured while performing a breathing protocol. Results: The probe has 512 unique source–detector (S-D) pairs that span S-D separations of 10 to 54 mm. It exhibited good performance characteristics: drift of 0.34%/h, precision of 0.063%, and mean up to 41 mm S-D separation. Absorption contrast was detected in flow phantoms at depths exceeding 28 mm. A cuff occlusion measurement confirmed the ability of the probe to track expected hemodynamics in vivo . Breast measurements on healthy volunteers during paced breathing revealed median signal-to-motion artifact ratios ranging from 8.1 to 8.7 dB. Median and amplitudes ranged from 0.39 to and 0.08 to , respectively. Median oxygen saturations at the respiratory rate ranged from 82% to 87%. Conclusions: A wearable diffuse optical probe has been designed and fabricated for the measurement of breast tissue hemodynamics. This device is capable of quantifying breathing-related hemodynamics in healthy breast tissue.

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“…Many optical imaging methods for diagnosis and treatment monitoring have been reported [10][11][12][13], and we have established a two-dimensional optical imaging system with time-resolved spectroscopy (TRS) for breast cancer surveillance, as previously reported [14]. TRS is a technique that measures the time of flight, in addition to the light intensity, at the boundary of a medium.…”

Section: Introductionmentioning

confidence: 98%

Early Therapeutic Prediction Based on Tumor Hemodynamic Response Imaging: Clinical Studies in Breast Cancer with Time-Resolved Diffuse Optical Spectroscopy

Ueda

Sendo

2018

Applied Sciences

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This study reports data from three clinical studies using the time-resolved diffuse optical spectroscopy (TRS) system among breast cancer patients. The parameters of oxy-hemoglobin (O2Hb), deoxy-hemoglobin (HHb), total hemoglobin (tHb), and oxygen saturation (SO2) were evaluated using TRS, and its efficacy was tested in three trials. In trial 1, we recruited 118 patients with primary breast cancer to estimate the tumor detection rate. The cumulative detection rate was 62.7%, while that in T stage 0 was 31.3% and in T stage 1 was 44.7%. These were lower than those of T stage 2 (78.9%) and T stage 3 (100%). Next, we used TRS to monitor tumor hemodynamic response to neoadjuvant chemotherapy (n = 100) and found that pathological complete response (pCR) tumors had significantly lower tumor tHb than non-pCR tumors; a similar result was observed in estrogen receptor (ER)-negative tumors, but not in ER-positive tumors. The third trial monitored hemodynamic response to antiangiogenic therapy, bevacizumab (n = 28), and we demonstrated that sequential optical measurement of tumor SO2 might be useful for detecting acute hypoxia 1–3 days after bevacizumab initiation. Next, response monitoring of neoadjuvant endocrine therapy (n = 30) suggested that changes in tumor tHb during treatment can predict and distinguish between responsive and non-responsive tumors early in letrozole therapy. In conclusion, our results show that hemodynamic monitoring of tumors by TRS could pair the unique features of tumor physiology to drug therapy and contribute to patient-tailored medicine. We recently established a platform for performing TRS in patients with breast cancer.

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Breast tumor hemodynamic response during a breath-hold as a biomarker to predict chemotherapeutic efficacy: preclinical study

Cited by 3 publications

References 22 publications

Use of Hypoxic Respiratory Challenge for Differentiating Alzheimer’s Disease and Wild-Type Mice Non-Invasively: A Diffuse Optical Spectroscopy Study

Use of Hypoxic Respiratory Challenge for Differentiating Alzheimer’s Disease and Wild-Type Mice Non-Invasively: A Diffuse Optical Spectroscopy Study

High optode-density wearable diffuse optical probe for monitoring paced breathing hemodynamics in breast tissue

Early Therapeutic Prediction Based on Tumor Hemodynamic Response Imaging: Clinical Studies in Breast Cancer with Time-Resolved Diffuse Optical Spectroscopy

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