Breath pentane concentrations during labor and the effect of epidural analgesia on the pentane concentration

Shin, Young Kwan; Collea, Joseph V.; Kim, Y.D.; Kim, S.Y.

doi:10.1016/s0959-289x(97)80002-7

Cited by 8 publications

(2 citation statements)

References 21 publications

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“…The result was demonstrated by the box-and-whisker plots as shown in Figure b. Higher concentrations of n -butane and n -pentane were found in three smokers, which was consistent with literature reports that oxidative stress might be induced by the toxicity of xenobiotics (free radicals) from cigarette smoke and oxidative injury could be reflected by elevated concentrations of exhaled n -alkanes. − Generally, the median concentrations of exhaled n -butane, n -pentane, and n -hexane in 20 healthy nonsmokers were 5.55, 1.41, and 0.83 ppbv, respectively, which was similar to the literature report. − This result has demonstrated that HPPI-OCI MS is a robust and reliable method for real sample analysis.…”

Section: Resultssupporting

confidence: 87%

Direct Detection of Small n-Alkanes at Sub-ppbv Level by Photoelectron-Induced O₂⁺ Cation Chemical Ionization Mass Spectrometry at kPa Pressure

Wang

Lee

et al. 2018

Anal. Chem.

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Direct mass spectrometric measurements of saturated hydrocarbons, especially small n-alkanes, remains a great challenge because of low basicity and lack of ionizable functional groups. In this work, a novel high-pressure photoelectron-induced O cation chemical ionization source (HPPI-OCI) at kPa based on a 10.6 eV krypton lamp was developed for a time-of-flight mass spectrometer (TOFMS). High-intensity O reactant ions were generated by photoelectron ionization of air molecules in the double electric field ionization region. The quasi-molecular ions, [M-H], of C3-C6 n-alkanes, gradually dominated in the mass spectra when the ion source pressure was elevated from 88 to 1080 Pa, with more than 3 orders of magnitude improvement in signal intensity. As a result, the achieved limits of detection were lowered to 0.14, 0.11, 0.07, and 0.1 ppbv for propane, n-butane, n-pentane, and n-hexane, respectively. The performance of the HPPI-OCI TOFMS was first demonstrated by analysis of exhaled small n-alkanes from healthy smokers and nonsmokers. Then the concentration variations of exhaled small n-alkanes of four healthy volunteers were analyzed after alcohol consumption to explore the alcohol-hepatoxicity-related oxidative stress. In summary, this work provides new insights for controlling the O-participating chemical ionization by adjusting the ion source pressure and develops a novel direct mass spectrometric method for sensitive measurements of mall n-alkanes.

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Section: Resultssupporting

confidence: 87%

Direct Detection of Small n-Alkanes at Sub-ppbv Level by Photoelectron-Induced O₂⁺ Cation Chemical Ionization Mass Spectrometry at kPa Pressure

Wang

Lee

et al. 2018

Anal. Chem.

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“…Thus, ethane reflects the main source of oxidative degradation of PUFAs. Measurements of breath ethane may provide a sensitive marker of in vivo lipid peroxidation that directly indicates when physiological events in the subject occur (Shin et al, 1997;Knutson et al, 2000).…”

Section: Hydrocarbonsmentioning

confidence: 99%

Human exhaled air analytics: biomarkers of diseases

Buszewski

Kęsy

Ligor

et al. 2007

Biomedical Chromatography

692

531

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Over the last few years, breath analysis for the routine monitoring of metabolic disorders has attracted a considerable amount of scientific interest, especially since breath sampling is a non-invasive technique, totally painless and agreeable to patients. The investigation of human breath samples with various analytical methods has shown a correlation between the concentration patterns of volatile organic compounds (VOCs) and the occurrence of certain diseases. It has been demonstrated that modern analytical instruments allow the determination of many compounds found in human breath both in normal and anomalous concentrations. The composition of exhaled breath in patients with, for example, lung cancer, inflammatory lung disease, hepatic or renal dysfunction and diabetes contains valuable information. Furthermore, the detection and quantification of oxidative stress, and its monitoring during surgery based on composition of exhaled breath, have made considerable progress. This paper gives an overview of the analytical techniques used for sample collection, preconcentration and analysis of human breath composition. The diagnostic potential of different disease-marking substances in human breath for a selection of diseases and the clinical applications of breath analysis are discussed.

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Clinical Applications

Gruber

2014

Practical Gas Chromatography

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Breath pentane concentrations during labor and the effect of epidural analgesia on the pentane concentration

Cited by 8 publications

References 21 publications

Direct Detection of Small n-Alkanes at Sub-ppbv Level by Photoelectron-Induced O₂⁺ Cation Chemical Ionization Mass Spectrometry at kPa Pressure

Direct Detection of Small n-Alkanes at Sub-ppbv Level by Photoelectron-Induced O₂⁺ Cation Chemical Ionization Mass Spectrometry at kPa Pressure

Human exhaled air analytics: biomarkers of diseases

Clinical Applications

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Breath pentane concentrations during labor and the effect of epidural analgesia on the pentane concentration

Cited by 8 publications

References 21 publications

Direct Detection of Small n-Alkanes at Sub-ppbv Level by Photoelectron-Induced O2+ Cation Chemical Ionization Mass Spectrometry at kPa Pressure

Direct Detection of Small n-Alkanes at Sub-ppbv Level by Photoelectron-Induced O2+ Cation Chemical Ionization Mass Spectrometry at kPa Pressure

Human exhaled air analytics: biomarkers of diseases

Clinical Applications

Contact Info

Product

Resources

About

Direct Detection of Small n-Alkanes at Sub-ppbv Level by Photoelectron-Induced O₂⁺ Cation Chemical Ionization Mass Spectrometry at kPa Pressure

Direct Detection of Small n-Alkanes at Sub-ppbv Level by Photoelectron-Induced O₂⁺ Cation Chemical Ionization Mass Spectrometry at kPa Pressure