Bronchial hypersensitivity to extract of Candida albicans

Itkin, Irving H.; Dennis, Macey

doi:10.1016/0021-8707(66)90113-4

Cited by 46 publications

(23 citation statements)

References 17 publications

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“…On the other hand, neither hyphae nor spores of O7/)rf/(/fl were detected in the involved tissues. It is, therefore, suggested that the disease may be caused by absorption of soluble antigenic substances of the fungus into the lymph and/or blood vessels rather than by growth of the fungus in the tissues, since atopic fungus allergy is usually caused by soluble fungal substances (Itkin & Dennis, 1966). If this disease is caused by absorption of such soluble substances., further questions remain to be answered, such as; why are there no systemic reactions or skin manifestations or disorders of the digestive tract?…”

Section: Discussionmentioning

confidence: 99%

Histological and immunological studies on eosinophilic granuloma of soft tissue, so‐called Kimura's disease

Takenaka¹,

Okuda

Usami

et al. 1976

Clin Experimental Allergy

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Summary Increase of serum IgE with frequent localization of IgE in the germinal centres, mast cell hyperplasia in lymph nodes and changes of specific granules in the infiltrated eosinophils, such as roughness of the matrix and appearance of tubular structures together with fusing and disappearance of the core, were demonstrated in eosinophilic granuloma of the soft tissue, so‐called Kimura's disease, in association with increase of anti‐Candida IgE antibody. It is suggested that this disease may be due to atopic allergy to Candida albicans.

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Section: Discussionmentioning

confidence: 99%

Histological and immunological studies on eosinophilic granuloma of soft tissue, so‐called Kimura's disease

Takenaka¹,

Okuda

Usami

et al. 1976

Clin Experimental Allergy

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“…To date, the significance of C. albicans in allergic respiratory disease is still unclear [4]. There have been reports indicating correlation between the immediate skin test, bronchial challenge test and radio-allergosorbent test (RAST) to C. albicans [1,[5][6][7][8]. However, lack of apparent clinical association with positive skin tests in many asthmatic patients results in uncertainty in the role of C. albicans in clinical allergy [4].…”

Section: Introduetionmentioning

confidence: 99%

Allergenic components of Candida albicans identified by immunoblot analysis

Shen

Choo

Tang

et al. 1989

Clin Experimental Allergy

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Allergenic components of Candida albicans fractionated by SDS-polyacrylamide gel electrophoresis (PAGE) and transferred to nitrocellulose membranes were identified using sera from 30 asthmatic patients who showed positive skin test and RAST (radio-allergosorbent test) to C. albicans. The IgE-binding yeast components in the complex antigen preparation were then detected by reaction with enzyme-labelled anti-human IgE antibodies. They were confirmed by Coomassie blue R-250 staining of the membrane to visualize all protein bands after reaction with the enzyme substrate. The IgE-binding patterns of the sera tested were heterogeneous, displaying a total of 16 identifiable components with molecular weights ranging from 20 to 94 kD. A 40 kD component showed the highest IgE-binding frequency, being recognized by 23 (77%) of the 30 sera examined. The other 15 allergenic components identified were recognized by less than 25% of the sera tested. Only two of the 30 serum samples contained IgE antibodies reactive with seven to eight allergenic components. Ten of the 30 sera reacted with only one allergenic component, and the remaining serum samples recognized two to five of the 16 identified allergens. Results described in this study are applicable to allergen standardization work and provide a basis for further study on the role of C. albicans in clinical allergy.

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“…Though evidence on Candida allergy has been shown (2,7,8,9), knowledge of the individual allergens is limited. Though evidence on Candida allergy has been shown (2,7,8,9), knowledge of the individual allergens is limited.…”

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confidence: 99%

IgE‐, IgA‐ and IgG‐antibody responses to carbohydrate and protein antigens of Candida albicans in asthmatic children

Savolainen

Viander

Koivikko

1990

Allergy

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Analysis of IgE, IgA and IgG antibodies directed against Candida albicans antigens in 28 asthmatic children was performed with immunoblotting after SDS-PAGE. Analysis with the purified cytoplasmic protein fraction revealed a major protein allergen with an MW of 46 kD. In addition to the major allergen, 15 other antigenic bands with molecular weights between 16 and 135 kD bound IgE. Ten of 13 anti-C. albicans IgE-positive children had IgE towards the 46 kD major allergen. None of the subjects in the study group or in the non-atopic controls had IgA or IgG antibodies towards this protein. Analysis of the crude surface extract showed that mannan, a carbohydrate, was an intermediate allergen contrary to being the major antigen in IgA and IgG antibody responses.

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Bronchial hypersensitivity to extract of Candida albicans

Cited by 46 publications

References 17 publications

Histological and immunological studies on eosinophilic granuloma of soft tissue, so‐called Kimura's disease

Histological and immunological studies on eosinophilic granuloma of soft tissue, so‐called Kimura's disease

Allergenic components of Candida albicans identified by immunoblot analysis

IgE‐, IgA‐ and IgG‐antibody responses to carbohydrate and protein antigens of Candida albicans in asthmatic children

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