Bronchiectasis: functional significance of areas of decreased attenuation at expiratory CT.

Hansell, David M.; Wells, Adrian; Rubens, M B; Cole, P J

doi:10.1148/radiology.193.2.7972745

Cited by 165 publications

(86 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The nature of the link between bronchial and bronchiolar abnormalities is unclear. It has previously been suggested that decreased airflow in the small airways may reduce the efficacy of clearance of secretions in the large airways during coughing, increasing susceptibility to bronchial infection and thus leading to damage [116]. However, given the anatomical continuity of the bronchial tree, it may be that the wall thickening of macroscopic bronchi, visible on thin-section CT, is merely a surrogate for invisible bronchiolar abnormalities; the original insult to the airways having affected both the bronchi and bronchioles equally ( fig.…”

Section: Morphological-functional Correlations In Constrictive Bronchmentioning

confidence: 99%

Small airways diseases: detection and insights with computed tomography

Dm¹

2001

Eur Respir J

146

View full text Add to dashboard Cite

Diseases affecting the small airways are difficult to detect by traditional diagnostic tests. Widespread involvement is needed before symptoms and abnormalities on pulmonary function testing or chest radiography become apparent. Obstruction of the bronchioles may be detected indirectly by computed tomography (CT) because regional under-ventilation results in reduced perfusion which in turn is shown as a mosaic attenuation pattern of the lung parenchyma. When there is inflammation of the bronchioles with accompanying exudate, the airways may become directly visible on CT, for example in cases of diffuse panbronchiolitis.Quantification of the various morphological features of small airways disease is possible from CT images and this increased precision has aided investigations of structure/function relationships.An understanding of the pathology and microscopic distribution of disease in relation to the airways allows some prediction of the likely computed tomography appearances in this wide spectrum of conditions, and thus helps to refine the differential diagnosis.

show abstract

Section: Morphological-functional Correlations In Constrictive Bronchmentioning

confidence: 99%

Small airways diseases: detection and insights with computed tomography

Dm¹

2001

Eur Respir J

146

View full text Add to dashboard Cite

show abstract

“…11,12 The mechanisms of airway obstruction are not fully known but possibly involve the collapse of large airways at expiration, the bronchial wall thickening, retention of endobronchial secretion, and obliterative bronchitis. 13,14 Interestingly, many patients with bronchiectasis may also show a concomitant restrictive defect. Some authors believe that the progressive bronchiectatic changes may be the cause of the mixed pulmonary function defect.…”

mentioning

confidence: 99%

Impact of Different Etiologies of Bronchiectasis on the Pulmonary Function Tests

Lopes

Camilo

Menezes

et al. 2014

Clinical Medicine & Research

View full text Add to dashboard Cite

show abstract

“…A number of individual morphological features identifiable on CT in patients with bronchiectasis have functional significance [10][11][12]. Thus, there are potential roles for serial CT in mapping the evolution of bronchiectasis and providing explanations for fluctuations in PFTs during follow-up.…”

mentioning

confidence: 99%

A comparison of serial computed tomography and functional change in bronchiectasis

Sheehan¹,

Wells²,

Copley³

et al. 2002

Eur Respir J

130

View full text Add to dashboard Cite

In bronchiectasis the morphological determinants of (marginal) fluctuations in pulmonary function tests are uncertain. The aim of the present study was to evaluate serial computed tomography (CT) changes in relation to pulmonary function trends in patients with bronchiectasis.The relationships between pulmonary function indices and CT scans in 48 adult patients with bronchiectasis were evaluated at baseline and at follow-up, at a median interval of 28 months (range 6-74 months). Two independent observers semiquantitatively scored CT features of bronchial and small airways disease.At initial assessment, the severity of airflow obstruction was linked primarily to the extent of mosaic attenuation. However, serial changes in pulmonary function indices were only associated with serial changes in mucous plugging scores. Alterations in mucous plugging on serial CT were associated with changes in the severity of bronchiectasis and bronchial wall thickness. Greater severity of all three morphological abnormalities at baseline CT were predictive of significant declines in forced expiratory volume in one second, with severe bronchial wall thickness being the most adverse prognostic determinant.Variations in mucous plugging on computed tomography correlate with minor fluctuations in pulmonary function tests in bronchiectasis. However, the severity of bronchial wall thickness is the primary determinant of subsequent major functional decline. Eur Respir J 2002; 20: 581-587.

show abstract

Bronchiectasis: functional significance of areas of decreased attenuation at expiratory CT.

Abstract: Areas of decreased attenuation on expiratory CT scans are common in severe bronchiectasis. Such areas in lobes without overt bronchiectasis suggest that small airways disease may precede the development of bronchiectasis.

Cited by 165 publications

References 0 publications

Small airways diseases: detection and insights with computed tomography

Small airways diseases: detection and insights with computed tomography

Impact of Different Etiologies of Bronchiectasis on the Pulmonary Function Tests

A comparison of serial computed tomography and functional change in bronchiectasis

Contact Info

Product

Resources

About