Bronchodilator activity of aqueous extract of stem bark of<i>Ailanthus excelsa</i>Roxb.

Kumar, Dinesh; Bhujbal, Santosh S.; Deoda, R. S.; Mudgade, S. C

doi:10.4103/0974-8490.62955

Cited by 15 publications

(4 citation statements)

References 5 publications

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“…Neubaur’s chamber was charged with above fluid and eosinophilis were counted. The difference in eosinophil count before and after 24 h of the treatment was calculated [ 32 , 33 ].…”

Section: Methodsmentioning

confidence: 99%

In vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of Gymnemic Acid Isolated from Gymnema sylvestre R Br

Arun

Arunachalam

et al. 2014

BMC Complement Altern Med

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BackgroundGymnema sylvestre is a highly valued ethno pharmacologically important medicinal plant used currently in many poly-herbal formulations due to its potential antidiabetic activity and other health benefits. The present study was carried out to analyze the anti-stress, anti-allergic, and antiulcer activity of the bioactive compounds present in Gymnema sylvestre leaves.MethodsThe preliminary phytochemical screening for bioactive compounds from aqueous extracts revealed the presence of alkaloids, triterpenes, flavonoids, steroids, and saponins. The antioxidant activities were investigated using DPPH radical scavenging method. The characterization of the extract was carried out using standard compound by High Performance Thin Layer Chromatography (HPTLC) and phytochemical analysis in terms of total phenol, total flavonoids, reducing power and antioxidant potentials, etc. The in vivo studies on albino mice proved the purified fraction has anti-stress/anti-allergic activity against milk induced leucocytosis/eosinophilia and able to inhibit the aspirin induced gastric ulcers.ResultsThe quantitative estimation for aqueous extract exhibited total antioxidant (9.13 ± 0.04 μg/g), flavonoids (125.62 ± 26.84 μg/g), tannin (111.53 ± 15.13 μg/g), total phenol content (285.23 ± 1.11 μg/g) and free radical scavenging (52.14 ± 0.32%). Further the aqueous extract was consecutively purified by TLC and silica column chromatography. The purified fractions were characterized by HPTLC and GC-MS and the component was identified as gymnemic acid. The potency of the antimicrobial activity of the extract was studied with bacteria. Pharmacological experiments clearly demonstrated that the extracts of all plants given orally showed significant gastric protection against the asprin-induced gastric ulcer model in mice. Furthermore, healing effects were also confirmed through histopathological examination.ConclusionsThe aqueous extracts of the leaves of Gymnema sylvestre possess anti ulcerogenic, Anti allergic, Anti stress, properties that may be due to cytoprotective mechanism. These results support the ethno medical uses of the plant in the treatment of gastric ulcer.

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“…Neubaur’s chamber was charged with above fluid and eosinophilis were counted. The difference in eosinophil count before and after 24 h of the treatment was calculated [ 32 , 33 ].…”

Section: Methodsmentioning

confidence: 99%

In vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of Gymnemic Acid Isolated from Gymnema sylvestre R Br

Arun

Arunachalam

et al. 2014

BMC Complement Altern Med

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“…They have tested its bronchodilator efficacy in a variety of animal and human models, including those with milk-induced leukocytosis and eosinophilia, clonidine-induced mast cell degranulation, bronchoalveolar lavage fluid (BALF) and lung histology. Significant action was observed at 100, 200 and 400 mg/kg of the aqueous extract of stem bark 21 .…”

Section: Antifertility Activity: Ravichandran Et Al; Evaluated the Ac...mentioning

confidence: 99%

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2023

IJPSR

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The genus Ailanthus, which includes both evergreen and deciduous species, is native to both Asia and northern Australia. Traditional medicine relies heavily on this plant, and various components of the plant are utilized to treat a wide range of illnesses. Herbal and ayurvedic drugs have gained worldwide attention over the past decade for their potential health and financial benefits. There are now major worries about the quality, safety, and efficacy of herbs due to their regular and extensive use around the world. As a result, credible scientific data or evaluation is required before health claims made about herbs may be considered valid. The foundation for this tree's status as a plant of heaven includes the traditional assertions, phytochemical studies, pharmacological examination and some ayurvedic formulations. Therapeutic effects are found throughout the plant. The bark is employed in treating dysentery, earaches, skin diseases, rectum problems, fever related to tridosha and alleviating thirst. Furthermore, it is prescribed for patients suffering from bronchitis, asthma, bronchitis, dyspepsia, gout and rheumatism. In Ayurveda, it is recommended for those with a sour palate. Extracts from the bark of the stem were shown to have strong antibacterial and antifungal properties. Flavonoids, quassinoids, alkaloids, terpenoids, sterols and saponins have all been found in this plant. Ethnobotanical research shows that Ailanthus excelsa Roxb (AER) is full of different chemical compounds that may have a wide range of effects on living things. The traditional claims, as well as the pharmacognostical, phytochemical, pharmacological, and future potential of this plant are discussed in this review. Researchers are still looking for ways to use naturally occurring molecules to treat human diseases, according to new information. This information also points the way toward discovering more naturally occurring and new semisynthetic or synthetic compounds with similar effects.

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“…Based on the results of preliminary toxicity testing the doses of 100, 200 and 400 mg/kg p.o. were chosen for further experiments (Kumar D et al, 2010c).…”

Section: Acute Toxicity Studiesmentioning

confidence: 99%

“…In addition, Ailanthus excelsa was shown to have antipyretic activity (Suresh et al, 1995). Even though A. excelsa was reported to be useful in a many ailments like stem bark of A. excelsa was potent antiasthmatic, bronchodilator (Kumar D et al, 2010a;Kumar D et al, 2010b;Kumar D et al, 2010c). From a pharmaceutical perspective flavonoids possess a remarkable spectrum of biochemical and pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Antiasthmatic and antiallergic potential of methanolic extract of leaves of Ailanthus excelsa

Kumar¹,

Bhat²,

Singh³

et al. 2011

Rev. bras. farmacogn.

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The aim of study was antiasthmatic potential of methanolic extract of leaves of Ailanthus excelsa Roxb., Simaroubaceae. Traditionally or in Indian system of medicine, A. excelsa is used in the treatment of asthma, cough, colic pain, cancer, diabetes and also used as antispasmodic, antifertility, bronchodilator. Stem bark of A. excelsa already reported for its potential against asthma. The pollens of Ailanthus excelsa reported allergic in nature and the time of collection of leaves were important in this study, generally the fl owering stage of plant was avoided for the collection due to maximum chance of pollens at that time. Methanolic extract of leaves of A. excelsa was evaluated using in vitro goat tracheal chain preparation model and in vivo-Milk induced leucocytosis, eosinophilia, Clonidine induced catalepsy in mice model while Passive paw anaphylaxis and Clonidine induced mast cell degranulation in rat model. The extract showed the presence of fl avonoids, terpenoids, saponins, quassonoids and test was also positive for alkaloids and steroids. The extract also showed the presence of quercetin which is fl avonoid and detected on the preparative TLC plate with the help of standard quercetin. Dose response studies of methanolic extract of leaves of A. excelsa Roxb. were conducted at 100 µg mL

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Bronchodilator activity of aqueous extract of stem bark ofAilanthus excelsaRoxb.

Cited by 15 publications

References 5 publications

In vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of Gymnemic Acid Isolated from Gymnema sylvestre R Br

In vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of Gymnemic Acid Isolated from Gymnema sylvestre R Br

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Antiasthmatic and antiallergic potential of methanolic extract of leaves of Ailanthus excelsa

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