Brucellosis with pulmonary involvement in a premature infant

Köklü, Esad; Büyükkayhan, Derya; Akçakuş, Mustafa; Kurtoğlu, Selim; Köklü, Selmin; Güneş, Tamer

doi:10.1179/146532806x152917

Cited by 15 publications

(14 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The main findings in congenital brucellosis cases reported in the literature was respiratory distress syndrome associated with sepsis, preterm birth and meconium aspiration syndrome (33,(66)(67)(68). Brucella species can be transmitted transplacentally during delivery and by breast feeding in postpartum period (69). In endemic regions, the mother and newborn should be examined cautiously and an efficient drug therapy should be planned by the clinician as soon as brucellosis is diagnosed.…”

Section: Congenital Brucellosismentioning

confidence: 99%

The Effect of Brucellosis on Women’s Health and Reproduction

Kurdoğlu¹,

Cetin²,

Kurdoğlu³

et al. 2015

IJWHR

View full text Add to dashboard Cite

IntroductionBrucellosis is a zoonotic disease of worldwide distribution which still remains endemic in some developing countries, causing devastating economic losses. Since it is transmissible to humans through direct contact with infected animals, consumption of their milk and dairy products, or inhalation of contaminated aerosols, it is considered a big threat for public health. At this point, the effect of Brucella infection on women's health and reproduction gains an extraordinary importance due to its potential harmful effects on female reproductive system and pregnancy. Therefore, in this report we aimed to review the available literature related to human brucellosis in order to characterize the basic microbiological features as well as the risk factors and clinical presentations of the disease and its complications related to various aspects of reproductive health. Materials and MethodsIn order to look for original articles, review articles, case series, case reports and editorials related to the effects of brucellosis on women's health and reproduction, various internet engines including PubMed, Up To Date, Google, Google Scholar and Cochrane Library were searched between February 2015 and June 2015. Directly or indirectly related information from 75 reports, the earliest reported in 1917 and the latest in 2015 were identified. The words used during the search process were "Brucella," "brucellosis, " "women's health, " "human pregnancy, " "human reproduction, " "abortion, " "preterm birth, " "intrauterine fetal demise, " and "intrauterine fetal death". Results General Features of Brucella Species and InfectionThe main pathogenic species worldwide are Brucella abortus (B. abortus), responsible for bovine brucellosis, Brucella melitensis (B. melitensis), the main etiologic agent of ovine and caprine brucellosis, and Brucella suis (B. suis), which has a wide host range, not being confined to swine (1). B. melitensis is responsible for the majority of human infections and is primarily food-borne. B. abortus and B. suis infections are generally sporadic and Brucella canis infections are the least common in humans and are generally laboratory-acquired (2,3). AbstractDue to its potential harmful effects on the general health and reproductive life of the women, in the light of available literature, it was aimed to review the effect of human brucellosis on women's health and reproduction. Data from 75 reports belonging to the years 1917 through 2015, obtained via a search on various internet sources by the words "Brucella", "brucellosis, " "women's health, " "human pregnancy, " "human reproduction, " "abortion, " "preterm birth, " "intrauterine fetal demise, " and "intrauterine fetal death" were used to characterize basic microbiological features together with the risk factors, clinical presentations and complications of the human brucellosis related to various aspects of reproductive well-being. A high rate of spontaneous abortion was a more consistent finding rather than high rates of preterm delivery and intra...

show abstract

Section: Congenital Brucellosismentioning

confidence: 99%

The Effect of Brucellosis on Women’s Health and Reproduction

Kurdoğlu¹,

Cetin²,

Kurdoğlu³

et al. 2015

IJWHR

View full text Add to dashboard Cite

show abstract

“…Premature delivery of a congenitally infected newborn presenting with disseminated brucellar disease and nonspecific signs of septicemia that were similar to those observed in patient 2 has also been repeatedly documented [21][22][23][24]. The negative Rose-Bengal screening test result observed in the neonate (patient 2) is consistent with the fact that IgG antibodies begin to be transferred from mother to fetus by an active transport mechanism after the 17th week of gestation, and IgM does not normally cross the placental barrier [25].…”

Section: Discussionmentioning

confidence: 73%

The Many Faces of Human-to-Human Transmission of Brucellosis: Congenital Infection and Outbreak of Nosocomial Disease Related to an Unrecognized Clinical Case

Mesner

Riesenberg

Biliar

et al. 2007

Clinical Infectious Diseases

View full text Add to dashboard Cite

Background. Because person-to-person transmission of brucellosis is exceptional, physicians who care for patients with this disease are not considered to be at increased risk. A woman in her 24th week of pregnancy who had received a diagnosis of placenta previa presented to the hospital with massive vaginal bleeding and hypovolemic shock, requiring performance of an emergency Cesarean delivery. Two physicians who assisted the surgical delivery developed culture-proven Brucella melitensis infection. The organism was also recovered from cultures of blood samples obtained from the mother and the premature newborn. The mother had been observed since early pregnancy because of an undiagnosed febrile hepatitis, but no specific tests for brucellosis had been performed. Retrospective testing of serum samples obtained at the onset of disease were positive for Brucella antibodies, indicating that the disease could have been diagnosed earlier.Methods. Hospital records of the obstetric, intensive care, and surgical departments were examined to identify all staff members who took care of the mother and her offspring. The identified personnel were interrogated about exposure to potentially infective blood and fomites and were screened by blood cultures and serologic tests for Brucella species.Results. An additional physician who assisted in the resuscitation of the newborn had a blood culture positive for B. melitensis and a positive result of a diagnostic serological test. Ninety-five other members of the hospital staff, who were potentially exposed to the organism, were found to be uninfected. Conclusions. Although rare, transmission of B. melitensis from patients to medical personnel may occur. Strict adherence to universal precautions, especially during performance of medical procedures characterized by massive blood exposure, should be reinforced.

show abstract

“…5,6,10,11 Congenital brucellosis associated with sepsis and pulmonary involvement has rarely been described. 4,5,7,8 Haematological and biochemical tests used in neonatal sepsis are of limited value for the diagnosis of brucellosis. In brucellosis, the white blood cell count is often normal or low.…”

Section: Discussionmentioning

confidence: 99%

“…Our infant presented initially with a high WBC, increased polymorphonuclear leucocytes and high CRP levels, all of which are associated with sepsis rather than brucellosis. Transplacental, perinatal [3][4][5][6][7][8][9][10][11] and via breast-milk 12,13 are among the main routes of Brucella transmission in mammalian reservoirs. It seems that in most cases Brucella passes through the placenta.…”

Section: Discussionmentioning

confidence: 99%