Objective
Growing evidence indicates that ambient (AAP: NO2,
PM2.5, and O3) and traffic-related (TRAP) air
pollutants contribute to metabolic disease risk in adults; however, few
studies have examined these relationships in children.
Methods
Metabolic profiling was performed in 429 overweight and obese
African-American and Latino youth living in urban Los Angeles, California.
This cross-sectional study estimated individual residential air pollution
exposure and used linear regression to examine relationships between air
pollution and metabolic outcomes.
Results
AAP and TRAP exposure were associated with adverse effects on glucose
metabolism independent of body fat percent. PM2.5 was associated
with 25.0% higher fasting insulin (p<0.001), 8.3% lower
insulin sensitivity (SI) (p<0.001), 14.7% higher acute insulin
response to glucose (AIRg) (p=0.001), and 1.7%
higher fasting glucose (p<0.001). Similar associations were observed for
increased NO2 exposure. TRAP from non-freeway roads was
associated with 12.1% higher insulin (p<0.001), 6.9%
lower SI (p=0.02), 10.8% higher AIRg
(p=0.003), and 0.7% higher fasting glucose
(p=0.047).
Conclusions
Elevated air pollution exposure was associated with a metabolic
profile that is characteristic of increased risk for type 2 diabetes. These
results indicate that increased prior year exposure to air pollution may
adversely affect type 2 diabetes-related pathophysiology in overweight and
obese minority children.