Bulk nanobubbles: Production and investigation of their formation/stability mechanism

Michailidi, Elisavet D.; Bomis, George; Varoutoglou, Athanasios; Kyzas, George Z.; Mitrikas, George; Mitropoulos, Athanasios C.; Efthimiadou, Eleni K.; Favvas, Evangelos P.

doi:10.1016/j.jcis.2019.12.093

Cited by 138 publications

(89 citation statements)

References 69 publications

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“…However, recent experimental studies showed that BNBs exist stably under atmospheric pressure, and their lifespan exceeds analytic expectations [17][18] . In addition, other investigators revealed that the interface of BNBs consists of hard hydrogen bonds that are similar to hydrogen bonds found in ice and gas hydrates 8,[19][20] .…”

Section: Resultsmentioning

confidence: 99%

Coarsening Behavior of Bulk Nanobubbles in Water

Lee

Huh

Park

et al. 2021

Preprint

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In recent years, extremely small gas bubbles called bulk nanobubbles (BNBs) have drawn great attention due to their impressive effects and their wide applicability in a variety of technological fields, including biomedical engineering, water treatment, and nanomaterials. However, unsolved questions remain regarding the stability and behavior of BNBs. In the present work, BNBs were generated in water using a gas-liquid mixing method. To investigate the coarsening behavior of BNBs in water over time, particle analysis was performed using a nanoparticle tracking analysis (NTA) method. Over time, the BNB diameter continuously increased (from 88.50 nm to 201.00 nm), and its cubic radius increased linearly (r3 ~ t). While the concentration of BNBs decreased (from 3.47 ×108 particles/mL to 0.61 ×108 particles/mL), the total volume of BNBs remained the same. Moreover, the size distribution broadened over time, and the concentration of larger BNBs gradually increased over time. These results indicate that relatively small BNBs disappear and larger BNBs grow through mass transfer between BNBs instead of dissolution of the gas and coalescence. In other words, BNBs underwent Oswald ripening; that is, gas molecules detached from smaller BNBs, diffused into the continuous phase, and then were absorbed into larger BNBs.

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Section: Resultsmentioning

confidence: 99%

Coarsening Behavior of Bulk Nanobubbles in Water

Lee

Huh

Park

et al. 2021

Preprint

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“…In other words, the bubble growth rate by coalescence and rectified diffusion extremely decreased compared with the bubbles in supersaturated DI water, because there are few bubble and low concentrated dissolved gas around the bubble interface in undersaturated DI water. Some of these bubbles diffused and disappeared in the water, and others existed as NBs through the stabilization process 38 , 39 . As a results, a large number of NBs can be easily generated and stably existed on undersaturated condition compared to supersaturated condition.…”

Section: Resultsmentioning

confidence: 99%

Effect of dissolved-gas concentration on bulk nanobubbles generation using ultrasonication

Lee

Yim

Kim

2020

Sci Rep

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In this study, the effects of dissolved-gas concentration in liquid water on the nucleation and growth of bubbles and nanobubble (NB) generation were investigated by measuring the concentration and size distribution of NBs. Three types of liquids with different dissolved-gas concentrations—undersaturated, saturated, and supersaturated deionized (DI) water—were prepared, and NBs were generated via ultrasonic irradiation. As the dissolved-gas concentration increased, a large number of bubbles with relatively large diameters (several tens of micrometers or more) were generated, but the NB concentration decreased. The surface tension decreased with an increase in the dissolved gas concentration, and thus, the tensile strength which required for bubble growth became lower. Therefore, there were barely any NBs in supersaturated conditions because of the accelerated nucleation and bubble growth.

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“…Lennar-Jones (LJ) interaction Matrix in Martini model. Energy parameters ( ε kJ/mol) summarized from the work of Marrink et al [1] =0.47 nm for all interaction groups except =0.62 nm for C1 bead interacting with charged beads (Q). Figure S1.…”

Section: Discussionmentioning

confidence: 99%

“…In other words, the feasibility of the above-obtained gas coarse-grained model can be further evaluated by the lipid nanobubble self-assembly simulations. In order for this, we set up the initial simulation systems as follows: (1) gas nanobubble, who owns varying radius and number of molecules, was placed at the center of the simulation box (12×12×12 nm 3 ). (2) 180 or 256 DPPC molecules were evenly dispersed in other spaces except the gas nanobubble.…”

Section: Lipid Nanobubble Self-assembly Simulations Further Validatedmentioning

confidence: 99%

“…Nanobubbles have many unique physicochemical properties and are reported to have better stability than microbubbles [1][2] , which show great potential in a series of biomedical applications including ultrasound molecular imaging [3][4] , drug/gene delivery [5][6] , water treatment [7][8] , sonoimmunotherapy [9] , and so on. Amphiphilic molecules such as lipids can self-assemble along the air-water interface of nanobubbles.…”

Section: Introductionmentioning

confidence: 99%

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Developing Martini Coarse-Grained Nitrogen Gas Model for Lipid Nanobubble Simulations

Tian¹,

Lin

2021

Preprint

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<p>By integrating the advantages of lipids’ biocompatibility and nanobubbles’ potent physicochemical properties, lipid nanobubbles show a great potential in ultrasound molecular imaging and biocompatible drug/gene delivery. However, under the interactions of the ultrasound, lipid nanobubbles may fuse with the cell membrane, changing the local membrane component and re-distributing encapsulated gas molecules into the hydrophobic region of the cell membrane, which may greatly affect the dynamics of certain membrane proteins and thus functions of cells. Although molecular dynamics simulation provides a useful computational tool to reveal the related molecular mechanisms, the lack of coarse-grained gas model greatly restricts this purpose. In the current work, we developed a Martini-compatible coarse-grained gas model based on the results of previous experiments and atomistic simulations, which could be used for lipid nanobubble simulations with complicated lipid components. By comparing the results of well-designed lipid nanobubble, lipid bi-monolayer and lipid bilayer simulations, we further revealed the role of membrane curvature and interleaflet coupling in the liquid-liquid phase separation of lipid membranes. It is worth mention that our developed coarse-grained nitrogen gas model can also be used for other gas-water interface systems such as pulmonary surfactant, which may overcome the possible artefacts arising from the usage of vacuum for gas phase. </p>

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Bulk nanobubbles: Production and investigation of their formation/stability mechanism

Cited by 138 publications

References 69 publications

Coarsening Behavior of Bulk Nanobubbles in Water

Coarsening Behavior of Bulk Nanobubbles in Water

Effect of dissolved-gas concentration on bulk nanobubbles generation using ultrasonication

Developing Martini Coarse-Grained Nitrogen Gas Model for Lipid Nanobubble Simulations

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