Bupivacain ile Yapılan Spinal Anestezi ile Spinal Sıvı Lipid Peroksidasyon Düzeyi ve Antioksidan Sisteminde Meydana Gelen Değişiklikler

Kamiloğlu, Nadide Nabil; Beytut, Enver; Kamiloğlu, Alkan

doi:10.9775/kvfd.2010.2322

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Changes in the enzyme’s activity could be related to differences in metabolic features between these cell types and call for further investigation. Nevertheless, lower GPx activity after ketamine treatment is in line with one previous report ( 38 ).…”

Section: Resultssupporting

confidence: 93%

The effects of ketamine on viability, primary DNA damage, and oxidative stress parameters in HepG2 and SH-SY5Y cells

Jurič,

Lovaković,

Zandona

et al. 2023

Archives of Industrial Hygiene and Toxicology

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Ketamine is a dissociative anaesthetic used to induce general anaesthesia in humans and laboratory animals. Due to its hallucinogenic and dissociative effects, it is also used as a recreational drug. Anaesthetic agents can cause toxic effects at the cellular level and affect cell survival, induce DNA damage, and cause oxidant/antioxidant imbalance. The aim of this study was to explore these possible adverse effects of ketamine on hepatocellular HepG2 and neuroblastoma SH-SY5Y cells after 24-hour exposure to a concentration range covering concentrations used in analgesia, drug abuse, and anaesthesia (0.39, 1.56, and 6.25 µmol/L, respectively). At these concentrations ketamine had relatively low toxic outcomes, as it lowered HepG2 and SH-SY5Y cell viability up to 30 %, and low, potentially repairable DNA damage. Interestingly, the levels of reactive oxygen species (ROS), malondialdehyde (MDA), and glutathione (GSH) remained unchanged in both cell lines. On the other hand, oxidative stress markers [superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT)] pointed to ketamine-induced oxidant/antioxidant imbalance.

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Section: Resultssupporting

confidence: 93%

The effects of ketamine on viability, primary DNA damage, and oxidative stress parameters in HepG2 and SH-SY5Y cells

Jurič,

Lovaković,

Zandona

et al. 2023

Archives of Industrial Hygiene and Toxicology

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“…α2-agonists, including xylazine, medetomidine and dexmedetomidine, are the most widely used sedatives in veterinary medicine [3,21,[48][49][50][51] . These drugs are also administered during general anaesthesia to improve analgesia and to decrease the dose of the anaesthetics used.…”

Section: Combination Of αLpha2-agonists With Anticholinergics For Anamentioning

confidence: 99%

Nasıl Daha İyi Anestezi Kombinasyonları Yapılabilir? Güncel Bilgilerin İncelenmesi

Pekcan¹

2016

Kafkas Univ Vet Fak Derg

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In the ever-developing world, the recent years have brought about a wide range of novelties and significant developments in the fields of veterinary anaesthesia and analgesia. In the not-too-distant past, it was believed that the pain threshold of animals was high and that pain was not felt by animals during surgery, when they were anaesthetised. It was considered that the only analgesic drugs that could be used during operation were non-steroidal anti-inflammatory drugs. Today, these suppositions are all accepted as fallacies across the world, and it is well-known that the administration of analgesic drugs should be started in the preoperative period. This article describes pain in animals, how pain perceived by the operated animal can be recognised, and if not treated, to which complications pain may lead. Furthermore, in the last part of the manuscript, complications associated with the use of atropine and α2-agonist combinations, and the adverse effects of anaesthesia-induced hypotension are also explained. This review is intended to provide an insight into recently developed novel practices and to elucidate some main issues, which may be confusing for the veterinary practitioner. Keywords: Anaesthesia, Analgesia, Pain, Cat, Dog Nasıl Daha İyi Anestezi Kombinasyonları Yapılabilir? Güncel Bilgilerin İncelenmesi ÖzetGelişen dünya ile beraber son zamanlarda veteriner anestezi ve analjezi alanında da pek çok değişiklikler, yenilikler ve ilerlemeler kaydedilmiştir. Eskiden hayvanların ağrı eşiklerinin yüksek olduğuna ve operasyon sırasında anestezi altında iken ağrının hissedilmediğine inanılırdı. Operasyon sırasında tek kullanılabilecek analjezik ilacın nonsteroidal antiinflamatuvar olabileceği düşünülüyordu. Bu inanışların yanlış olduğu artık tüm dünyada kabul edilmektedir, analjezik ilaçların uygulanmasına preoperatif dönemde başlanması gerekliliği bilinmektedir. Bu makalede, hayvanlardaki ağrı, operasyon sırasında gelişen ağrının nasıl anlaşılabileceği ve tedavi edilmediği takdirde gelişebilecek komplikasyonlar anlatılmıştır. Ayrıca, makalenin sonunda atropin ile α2-agonist kombinasyonlarının komplikasyonları ve anestezi sırasında oluşan hipotansiyonun yan etkileri üzerinde de durulmaya çalışılmıştır. Bu derleme ile veteriner hekimlerin kafalarında karışıklık yaratan bazı konulara ışık tutulması, son yıllarda gelişen yeni uygulamalara ve ilaç kombinasyonlarına yer verilmesi amaçlanmıştır.

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Bupivacain ile Yapılan Spinal Anestezi ile Spinal Sıvı Lipid Peroksidasyon Düzeyi ve Antioksidan Sisteminde Meydana Gelen Değişiklikler

Cited by 2 publications

References 22 publications

The effects of ketamine on viability, primary DNA damage, and oxidative stress parameters in HepG2 and SH-SY5Y cells

The effects of ketamine on viability, primary DNA damage, and oxidative stress parameters in HepG2 and SH-SY5Y cells

Nasıl Daha İyi Anestezi Kombinasyonları Yapılabilir? Güncel Bilgilerin İncelenmesi

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