Burden of Cervical Cancer in Indonesia: Findings From the Global Burden of Disease Study 1990–2017

Wahidin, Mugi; Febrianti, Rini; Susanty, Frides

doi:10.2991/ahsr.k.200215.040

Cited by 9 publications

(9 citation statements)

References 2 publications

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“…Pada tahun 2018, kanker serviks diperkirakan telah menelan sekitar 311 ribu korban (55%) dari 570 ribu penderita [1][2][3]. Di Indonesia, tercatat ada hampir 22,5 ribu penderita dan 135 ribu prevalensi pada tahun 2017, dimana 9,6 ribu diantaranya berakhir pada kematian [4].…”

Section: Pendahuluanunclassified

Potensi Senyawa Hidrazon berbasis Turunan 2-Tiohidantoin dan Hidrazida sebagai Inhibitor Protein E6 pada Kanker Serviks secara In Silico

Alam

Abidiy

Gunawan

et al. 2022

Akta Kimia Indonesia

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Every year, the prevalence of cervical cancer in the world is increasing. Cervical cancer can occur as a result of Human Papillomavirus (HPV) infection. Currently, E6 oncoprotein inhibition targeting tends to be chosen because it is safer and better as a therapeutic agent of cervical cancer. In addition, E6 is also a crucial virus that induces cervical cancer through the inactivation of the p53 protein so that effective materials are needed to inhibit the performance of E6 oncogenes. Hydrazone is a Schiff base compound that has an azomethine group (-NHN=CR-). It is this azomethine group that plays a role in various bioactivity, including antivirals and anticancer. In this study, hydrazone was derived from the derivatives of 2-thihidantoin and hydrazide. The compound 2-thihidantoin belongs to the heterocyclic group that plays an important role in drug chemistry such as anticonvulsant, antibacterial, antidiabetic, antiviral and anticancer. Thus, this compound can be an alternative agent for cervical cancer treatment. Before the synthesis of such materials, it is necessary to carry out bioactivity analysis using computing. The study of the in-silico method includes the creation of structures using Avogadro, optimization of molecular geometry using Gaussian 16, as well as the results of ligand-protein interactions (RMSD, KI, Binding Affinity, ADME, Binding Pocket, and Drugability score) using AutoDock 4.2, PyMol, LigPlot, SwissADME, PLIP Tools, and Protein Plus. The results showed that hydrazone compounds derived from 2-thiohidantoin and hydrazide derivatives have the potential to inhibit the E6 protein and can be used as oral drugs..

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Section: Pendahuluanunclassified

Potensi Senyawa Hidrazon berbasis Turunan 2-Tiohidantoin dan Hidrazida sebagai Inhibitor Protein E6 pada Kanker Serviks secara In Silico

Alam

Abidiy

Gunawan

et al. 2022

Akta Kimia Indonesia

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“…Various risk factors have been shown to increase the incidence of cervical cancer. Predispositions that are often reported include sociodemographic factors, including age, occupation, socioeconomic status, and sexual activity factors, including age at first sex, exposure to diethylstilbestrol (DES), sex with many sex partners, parity, low genital hygiene, smoking, history of venereal disease, chronic trauma to the cervix, not doing the HPV vaccine, and oral contraceptive use (larger than four years) [6,7]. This has certainly contributed to an increase in the number of cervical cancer cases.…”

Section: Introductionmentioning

confidence: 99%

Detection of Candida in Cervical Cancer Tissue by Periodic Acid Shiff and Gomori Methenamine Silver Staining

2023

Journal of Chemical Health Risks

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Introduction and Aim: Cervical cancer is a global health burden. Of all the cancer incidences reported in Indonesia, cervical cancer occupies the second position as the highest contributor to the incidence throughout the year, and the third position is the leading cause of death. Tissue culture and staining methods were used to diagnose the cervical cancer. This study aimed to compare Candida detection and the possibility of vulvovaginal candidiasis risk factors in cervical cancer tissue blocks stained with periodic acid-Schiff (PAS) and Gomori methenamine silver (GMS). Methods: This was an analytical observational study using a cross-sectional approach. This study compared PAS and GMS staining to detect Candida fungi in paraffin block tissue from individuals diagnosed with cervical cancer at the Anatomical Pathology Laboratory of Kediri Regency Regional General Hospital in 2021-2022. The sampling used Total sampling was carried out from March to December 2022. Data analyses were descriptively performed. Results: The incidence of cervical cancer was dominated by patients aged 51-60 years who belonged the decade 6. In this study, 32 blocks of cervical cancer tissues were deparaffinized and analyzed. A histopathological diagnosis of the examined cervical biopsy samples was obtained. A total of 81.25% had cervical squamous cell carcinoma, in 18.75% of the patients and cervical adenocarcinoma. The findings of this study show that staining with GMS can detect more Candida fungi than PAS staining. Microscopic examination showed that GMS staining had a more obvious contrast, marked by black structures in the green area. Thirteen samples (40.7%) of the 32 examined for vulvovaginitis. However, this study did not show that Candida invasion of the cervix is a risk factor for cervical cancer. Conclusion: PAS and GMS staining can be used to detect Candida fungi in cervical cancer tissue. GMS staining has higher accuracy in detecting Candida in cervical squamous cell carcinoma and cervical adenocarcinoma. The risk factors for fungal infections and the occurrence of cervical cancer require further investigation.

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“…The mortality rate is also increased, which 3,3 per 100.000 in 1990 and 3,7 per 100.000 in 2017. 1 The incidence rate of cervical cancer in pregnancy is extremely low. Of all women who were diagnosed with cervical cancer, 1 -3% were diagnosed when pregnant or postpartum.…”

Section: Introductionmentioning

confidence: 99%

Treatment Approach for A Rare Case of Cervical Cancer in Pregnancy

Putri¹,

Wiranegara²

2022

Indones J Obstet Gynecol

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Abstract Objective: To add a new overview of cervical cancer in pregnancy and to review several treatment approaches using available guidelines. Methods: Case report. Case: A 29 years old woman, gravida 3 para 2 in 10 weeks of pregnancy, was presented with vaginal bleeding and bloody vaginal discharge. Ultrasound examination showed a 10 weeks single live intrauterine fetus and a mass on the cervix. The histopathological report revealed a poorly differentiated cervical adenocarcinoma without invasion of lymphovascular space. Patient was diagnosed with cervical carcinoma FIGO stage IB3 in 10 weeks of pregnancy. The patient opted to unpreserved the pregnancy. Radical hysterectomy with fetus in situ and bilateral pelvic lymphadenectomy was performed. Patient was referred to undergo adjuvant radiation therapy. Conclusion: Cervical cancer in pregnancy is a rare and special condition that requires individual planning for the diagnostic and treatment approaches. Keywords: cervical cancer, cervical cancer in pregnancy, fetus in situ hysterectomy, pregnancy, radical hysterectomy. Abstrak Tujuan: Untuk menambah gambaran kasus mengenai kanker serviks dalam kehamilan serta membahas pendekatan terapi menggunakan pedoman – pedoman yang ada. Metode: Laporan kasus. Kasus: Seorang perempuan berusia 29 tahun dengan G3P2 usia kehamilan 10 minggu datang dengan keluhan perdarahan pervaginam dan keputihan bercampur darah. Hasil dari USG menunjukkan adanya janin berusia 10 minggu serta massa pada serviks. Hasil pemeriksaan histopatologi menunjukkan adanya adenokarsinoma serviks berdiferensiasi buruk tanpa invasi limfovaskuler. Pasien didiagnosis dengan kanker serviks stadium FIGO IB3 dalam kehamilan 10 minggu. Pasien setuju untuk dilakukan terminasi kehamilan. Pada pasien kemudian dilakukan laparotomi histerektomi radikal dengan fetus in situ serta limfadenektomi pelvik bilateral. Pasien kemudian dirujuk untuk dilakukan terapi ajuvan dengan radiasi. Kesimpulan: Kanker serviks pada kehamilan merupakan suatu kondisi khusus sehingga perencanaan diagnostik dan manajemen terapi membutuhkan perencanaan secara individual di setiap kasusnya. Kata kunci: Kanker, kanker serviks, kanker serviks dalam kehamilan, kehamilan, , histerektomi radikal, histerektomi dengan fetus in situ.

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Burden of Cervical Cancer in Indonesia: Findings From the Global Burden of Disease Study 1990–2017

Cited by 9 publications

References 2 publications

Potensi Senyawa Hidrazon berbasis Turunan 2-Tiohidantoin dan Hidrazida sebagai Inhibitor Protein E6 pada Kanker Serviks secara In Silico

Potensi Senyawa Hidrazon berbasis Turunan 2-Tiohidantoin dan Hidrazida sebagai Inhibitor Protein E6 pada Kanker Serviks secara In Silico

Detection of Candida in Cervical Cancer Tissue by Periodic Acid Shiff and Gomori Methenamine Silver Staining

Treatment Approach for A Rare Case of Cervical Cancer in Pregnancy

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