Bürgerinformationssysteme

Ultrastructural Changes in Rat Hepatocytes After Prolonged Fasting

“…In the hepatocytes of fasting animals, the authors found a distrupted structure of the nuclear membranes and mitocondria along with vacuolization and degranulation of the rough endoplasmic reticulum.Hepatocytes demonstrated a drastic hypertrophy of the GER zone. The most significant changes were seen in the glycogen deposits and smooth-granular endoplasmic reticulum (6,7,8,9). Similar to our findings the glikogen particles were reported to becoming uniformly distributed into the cytoplasm and rich in b particles as fasting prolonged.…”

“…The early effects of starvation hepatocytes is reported previously (7,8,9). Glycogen alterations in the parenchmal cell of the liver after varions of fasting were predicted ann, indeed, have been reported by early workers using the light microscope as well as by later investigators using electron microscope (10).…”