Burn wound healing effects of the root hydroethanolic extract of Cochlospermum planchonii in mice

Metowogo, Kossi; Fankibe, Nakpane; Kantati, Yendubé T.; Adi, Kodjo; Darré, Tchin; Eklu-Gadégbéku, Kwashie; Aklikokou, Kodjo

doi:10.4314/ijbcs.v14i9.24

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Quelle que soit l'étiologie, la brûlure provoque une destruction d'un certain nombre de cellules, de capillaires superficiels et d'ailleurs de nombreuses études se sont intéressées au processus de cicatrisation (Metowogo et al, 2020;Sene et al, 2020). Les zones brûlées sont sujettes à un oedème massif avec ischémie et augmentation de la perméabilité capillaire et cellulaire avec fuite massive d'eau, de protéines et d'électrolytes.…”

Section: Discussionunclassified

Profil de l’ionogramme sanguin chez les enfants brûlés du Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle de Ouagadougou (Burkina Faso)

Soudre¹,

Kiba²,

Kouraogo³

et al. 2021

Int. J. Bio. Chem. Sci

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Les brûlures de l’enfant peuvent être à l’origine de troubles ioniques graves, entrainant une morbi-mortalité importante. Ce travail avait pour objectif de décrire les perturbations de l’ionogramme sanguin chez les enfants brûlés, afin de contribuer à l’amélioration des soins. Il s’est agi d’une étude transversale rétrospective allant du 01 janvier 2017 au 30 juin 2019. Ont été inclus les enfants hospitalisés dans le service de chirurgie du CHU pédiatrique Charles de Gaulle pour brûlure et chez lesquels un ionogramme sanguin a été réalisé. L’étude a porté sur 212 enfants, avec un âge moyen de 38,52 mois et un sex ratio de 1,12. La surface corporelle brûlée moyenne était de 26,60% et le délai moyen d’admission de 5,71 heures. La mortalité était de 16,98%. L’ionogramme sanguin à l’entrée a retrouvé une hyponatrémie (27,88%), une hypobicarbonatémie (53,95%), une hypoprotidémie (26,67%) et une hyperchlorémie (53,59%). Au contrôle, ces troubles ioniques étaient toujours présents. S’y sont associées une hypocalcémie (30,43%), une hypomagnésémie (27,27%) et une hyperphosphatémie (28,79%). La natrémie, la bicarbonatémie et la protidémie à l’entrée étaient significativement plus basses chez les patients décédés. Les brûlures de l’enfant sont fréquentes. Leur évolution est marquée par des perturbations de l’ionogramme sanguin et une mortalité élevée.Mots clés : Brûlure, Ionogramme sanguin, Enfants, Burkina Faso. English title: Blood ionogram profile in burned children at the Charles de Gaulle University Pediatric Hospital of Ouagadougou (Burkina Faso)Burns in children can be the cause of serious ionic disorders, leading to significant morbidity and mortality. The aim of this study was to describe the disturbances in the blood ionogram of burnt children, in order to contribute to the improvement of care. This was a retrospective cross-sectional study from 01 January 2017 to 30 June 2019. Children hospitalised in the surgery department of the Charles de Gaulle Pediatric University Hospital for burns and in whom a blood ionogram was carried out were included. Our study involved 212 children, with an average age of 38.52 months and a sex ratio of 1.12. The average body surface area burned was 26.60% and the average admission time was 5.71 hours. Mortality was 16.98%. The blood ionogram at the entrance showed hyponatremia (27.88%), hypobicarbonatremia (53.95%), hypoprotidemia (26.67%) and hyperchloremia (53.59%). At the control, these ionic disorders were still present. They were associated with hypocalcaemia (30.43%), hypomagnesemia (27.27%) and hyperphosphatemia (28.79%). Natremia, bicarbonateemia and protidemia were significantly lower on admission in patients who died in the course of the evolution. Childhood burns are frequent at the CHUP-CDG; their evolution is marked by disturbances of the blood ionogram and high mortality.Keywords: Burns, Blood Ionogram, Children, Burkina Faso.

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Section: Discussionunclassified

Profil de l’ionogramme sanguin chez les enfants brûlés du Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle de Ouagadougou (Burkina Faso)

Soudre¹,

Kiba²,

Kouraogo³

et al. 2021

Int. J. Bio. Chem. Sci

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“…Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License of the camera from the wound. The pictures were then analyzed, and the wounds surfaces were evaluated on days 0, 3, 6, 9 and 12 post-excisions using the ImageJ 1.48v freeware [(National Institutes of Health, USA; https://imagej.nih.gov/ij), as previously described by Metowogo et al (2020). Contraction rates (Tx) were calculated using the formula:…”

Section: Measurement Of Wounds Surfacesmentioning

confidence: 99%

Hydroalcoholic extract of Adansonia digitatas trunk bark, in topical application, possess in vivo wound healing and in vitro anti-inflammatory and antioxidant activities

Abdou-Rachidou¹,

Yendubé²,

Komi³

et al. 2022

J. Pharmacognosy Phytother.

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Adansonia digitata is a tree plant used in west African local pharmacopoeia. This work aimed to evaluate the wound healing properties of its trunk bark's hydroethanolic extract in wistar rats. The model of excision wound was used. Wistar rats were treated post-excision topically with neutral carbopol gel (Control), carbopol gels containing 2.5 and 5% of A. digitata hydroethanolic trunk bark extract (ADHE) and L-Mesitran. Pictures were taken post excision for analysis. Biopsies were realized for histological examination of the skin excised and for hydroxyproline determination. In vitro membrane stabilization anti-inflammatory test, DPPH and FRAP antioxidant tests, and phytochemical tests were performed. The results show a better rate of contraction in ADHE 2.5 and 5% animals (+56 ± 0.52% and +68 ± 0.24% respectively) as earlier as on day three post-excision. The hydroxyproline assay confirmed a better collagen production in ADHE 2.5% and 5% animals (+102.5 ± 2.9%, and +107 ± 3.0% respectively). Histological analysis showed a rapid re-epithelialization in ADHE animals. The antiinflammatory test indicated an IC50 of 16.521 ± 0.525 µg/mL, very close to Aspirin (16.826 ± 0.341 µg/mL), showing a possible anti-inflammatory activity of ADHE. The extract reduced DPPH radical (IC50 of 344.985 ± 17.139 µg/mL) and ferric ions (EC50 = 178.689 ± 0.250 µg/mL). Phytochemical investigations revealed the presence of alkaloids, terpenoids, and polyphenolic compounds. Flavonoids in particular, with an amount of 51.694 ± 0.174 mgER/g, should explain the wound healing activity observed, making the hydroethanolic extract of A. digitata a potential remedy for excision wounds.

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Phytochemical screening and antimicrobial activities of hydroethanolic extracts from leaves and roots of Cochlospermum planchonii (Bixaceae)

Fankibe¹,

Metowogo²,

Kantati³

et al. 2020

J. Pharmacognosy Phytother.

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Cochlospermum planchonii is traditionally used in Togo in treating several diseases, including burn wounds which achievement requires anti-infective and good cicatrisation processes. This study aims to evaluate the antimicrobial properties of hydroethanolic extracts from leaves and roots of C. planchonii and its phytochemical composition. Five (05) bacterial strains were suspended in liquid media with plant extracts at various concentrations and then spread, after 24 h incubation, on solid media. The minimum inhibitory (MIC) and minimal microbicidal (MMC) concentrations were assessed. Phytochemical characterization tests were performed and flavonoids, tannins and total phenol contents were also determined. Hydroethanolic extracts from the leaves and roots of C. planchonii were active on all the germs tested, with MICs ranging from 0.782 to 50 mg/mL and MMCs ranging from 1.563 to 100 mg/mL. The bests activities were recorded with root extract against Staphylococcus aureus: MIC=0.782 mg/mL and MMC =1.563 mg/mL. The MMC/MIC ratios are all equal to 2, indicating that both roots and leaves have bactericidal activities rather than inhibitory activities. Phytochemical tests have demonstrated the presence of metabolites such as flavonoids, tannins, carbohydrates, sterols, triterpenes, saponosides, and an absence of alkaloids. Total phenols, tannins and total flavonoids amounts found were respectively 85.466 ± 0.289; 33.566 ± 0.503; 218.333 ± 0.577 µgRE/mg in root extracts, and 75.833 ± 0.289; 26.533 ± 0,053; 183.666 ± 0.577 µgRE/mg in leaf extracts. Both root and leaf hydroethanolic extracts of C. planchonii could be potential natural antimicrobial remedies.

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Burn wound healing effects of the root hydroethanolic extract of Cochlospermum planchonii in mice

Cited by 3 publications

References 25 publications

Profil de l’ionogramme sanguin chez les enfants brûlés du Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle de Ouagadougou (Burkina Faso)

Profil de l’ionogramme sanguin chez les enfants brûlés du Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle de Ouagadougou (Burkina Faso)

Hydroalcoholic extract of Adansonia digitatas trunk bark, in topical application, possess in vivo wound healing and in vitro anti-inflammatory and antioxidant activities

Phytochemical screening and antimicrobial activities of hydroethanolic extracts from leaves and roots of Cochlospermum planchonii (Bixaceae)

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