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Cancer is an emerging public health problem in sub-Saharan Africa. Several medicinal plants are used by traditional healers to treat tumors. In Togo, there are no recorded data for these plants but traditional healers claim to cure tumors with some success. So, information on medicinal plants used to cure human tumors and cancer could be of great importance for their widespread use and scientific validation. e present ethnopharmacological survey aims to record information on antitumor plants in central and Kara regions of Togo. Semistructured validated questionnaires were administered to fifty-seven traditional healers specialized in tumor management in 7 prefectures of Togo. Good practices and know-how were recorded. Quantitative ethnobotanical tools were used to analyze and summarize the data collected. 85 recipes of medicinal plants for tumors management are provided. In the local dialect, 78.95% of traditional healers do not have a clear tumor designation and 29.90% find that the causes of tumors remain unknown. According to 48.78% of traditional healers, the diagnosis of tumors in patients is made in the hospital. e types of tumors frequently treated are those of the breast (43.75%) and the lung (16.67%). e seventy listed medicinal plants belong to thirty-nine families, the most represented being Rubiaceae (17.95%), Caesalpiniaceae (12.82%), Fabaceae (10.26%), and Annonaceae (7.69%). e ten most cited species were Xylopia aethiopica, Aframomum melegueta, Khaya senegalensis, Parkia biglobosa, Piliostigma thonningii, Blighia sapida, Vitellaria paradoxa, Adansonia digitata, Annona muricata, and Parinari curatellifolia. Most of the recipes are prepared as decoction (40%) and administered orally (54.12%). Both regions of our study have a wealth of medicinal plants, and traditional healers would use their local knowledge in the management of various tumors and chronic wounds.

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Cochlospermum planchonii is traditionally used in Togo in treating several diseases, including burn wounds which achievement requires anti-infective and good cicatrisation processes. This study aims to evaluate the antimicrobial properties of hydroethanolic extracts from leaves and roots of C. planchonii and its phytochemical composition. Five (05) bacterial strains were suspended in liquid media with plant extracts at various concentrations and then spread, after 24 h incubation, on solid media. The minimum inhibitory (MIC) and minimal microbicidal (MMC) concentrations were assessed. Phytochemical characterization tests were performed and flavonoids, tannins and total phenol contents were also determined. Hydroethanolic extracts from the leaves and roots of C. planchonii were active on all the germs tested, with MICs ranging from 0.782 to 50 mg/mL and MMCs ranging from 1.563 to 100 mg/mL. The bests activities were recorded with root extract against Staphylococcus aureus: MIC=0.782 mg/mL and MMC =1.563 mg/mL. The MMC/MIC ratios are all equal to 2, indicating that both roots and leaves have bactericidal activities rather than inhibitory activities. Phytochemical tests have demonstrated the presence of metabolites such as flavonoids, tannins, carbohydrates, sterols, triterpenes, saponosides, and an absence of alkaloids. Total phenols, tannins and total flavonoids amounts found were respectively 85.466 ± 0.289; 33.566 ± 0.503; 218.333 ± 0.577 µgRE/mg in root extracts, and 75.833 ± 0.289; 26.533 ± 0,053; 183.666 ± 0.577 µgRE/mg in leaf extracts. Both root and leaf hydroethanolic extracts of C. planchonii could be potential natural antimicrobial remedies.

Anogeissus leiocarpus (Combretaceae) is a medicinal plant used by traditional practitioners to treat people living with diabetes mellitus in Togo. The objective of this work was to evaluate the hypoglycemic activity of the plant. The hydroalcoholic extract and fractions of A. leiocarpus roots was evaluated on hyperglycemic mice by oral glucose tolerance test (OGTT) and on normoglycemic mice. The effect of the total extract and fractions was also measured on the adsorption and absorption of glucose respectively in vitro and ex vivo. At 30 minutes after glucose overload, the total extract and all fractions (supernatant and pellet) significantly (p< 0.0001) reduced hyperglycemia compared to controls. However, this reduction in hyperglycemia was greater in mice treated with the supernatant fraction at 100 mg.kg-1 during 180 minutes (p < 0.01). In our conditions, the extract at the 500 mg.kg-1 of the total extract in normoglycemic mice did not significantly decrease (p>0.05) basal blood glucose levels compared to controls. In vitro, the extract and fractions of A. leiocarpus adsorbed glucose and inhibited glucose intestinal absorption ex vivo. The results of this study support the use of A. leiocarpus as an antidiabetic plant. Keywords:  Anogeissus leiocarpus- fractions- antihyperglycemic- adsorption – absorption.