Today we are living a new industrial revolution, which has its origin in the vertiginous deployment of ICT technologies that have been pervasively deployed at all levels of the modern society. This new industrial revolution, known as Industry 4.0, evolves within the context of a totally connected Cyber-Physic world in which organizations face immeasurable challenges related to the proper exploitation of ICT technologies to create and innovate in order to develop the intelligent products and services of tomorrow's society. This paper introduces a semantic-driven architecture intended to design, develop and manage Industry 4.0 systems by incrementally integrating monitoring, analysis, planning and management capabilities within autonomic processes able to coordinate and orchestrate Cyber-Physical Systems (CPS). This approach is also intended to cope with the integrability and interoperability challenges of the heterogeneous actors of the Internet of Everything (people, things, data and services) involved in the CPS of the Industry 4.0.