Buspirone Treatment of Anxious Alcoholics

Kranzler, Henry R.; Burleson, Joseph A.; Boca, Frances K. Del; Babor, Thomas F.; Korner, P.; Brown, Joseph; Bohn, Michael J.

doi:10.1001/archpsyc.1994.03950090052008

Cited by 229 publications

(84 citation statements)

References 53 publications

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“…Buspirone has been studied in such patients. One study (Kranzler et al, 1994) found an advantage in terms of drinking and anxiety but an earlier study (Malcolm et al, 1992) did not.…”

Section: Anxiety and Panic Disordermentioning

confidence: 93%

Medication in the treatment of alcohol dependence

Chick¹

1996

Adv. psychiatr. treat

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Social, cultural, emotional and biological influences determine whether people drink to excess and whether they then experience harm or cause harm to others (Cook, 1994). Psychosocial treatments for alcohol dependence are only modestly successful, with most studies finding that at least 50% of patients return to harmful drinking in the following year. In the past decade there has been new evidence for the role of pharmacological treatments in reducing harm from drinking and in preventing relapse.

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“…Buspirone has been studied in such patients. One study (Kranzler et al, 1994) found an advantage in terms of drinking and anxiety but an earlier study (Malcolm et al, 1992) did not.…”

Section: Anxiety and Panic Disordermentioning

confidence: 93%

Medication in the treatment of alcohol dependence

Chick¹

1996

Adv. psychiatr. treat

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“…[7] Depreşmeyi önlemek için uygulanan programlar istek azaltıcı veya anksiyolitik ilaç-larla birlikte de kullanılabilmektedir. [50][51][52] İlaçların genellikle uzun süre ve düzenli kullanılması gerekmektedir. Ancak konu ile ilgili yapılan araştırmalarda hastaların ilaç almayı reddetme, tedaviyi yarıda bırakma, düzenli kullanım konusunda aile üyeleri ve sağlık ekibiyle işbirliği yapmama gibi tedaviye uyumsuzluk olarak tanımlanabilecek davranışlar gösterdikleri saptanmıştır.…”

Section: Depreşmeyi öNlemede Bilişsel Davranışçı Modelunclassified

Remission and Relapse in Alcohol and Substance Addiction

Yılmaz¹,

Can²,

Bozkurt³

et al. 2014

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖzetAlkol ve madde bağımlılığı kronik bir hastalık olup alkol madde bağımlılığı geliştikten sonra yaşam boyunca devam etmektedir. Bu yüzden doğal gidişi remisyon ve depreşmeler belirler. Alkol madde bağımlılarında zaman zaman remisyon dönemleri arkasından depreşme dönemleri ortaya çıkabil-mekte ve bu depreşme dönemleri de kişileri alkol maddenin tüm olumsuz etkileri ile karşı karşıya bırakabilmektedir. Depreşme riskini belirleyen günümüze kadar pek çok faktörden söz edilmiştir. Bu faktörler bireysel, durumsal olabildiği gibi fizyolojik temelleri de olan faktörlerdir. Bunların birbirleri ile karşılıklı etkileşimi depreşme açısından oldukça önemlidir. Depreşme bağımlılık gelişmiş kişilerin tekrar alkol madde kullanmaya başlamalarını önlemek için üzerinde oldukça fazla çalışılmış bir alandır. Bağımlı hastaların remisyon dönemlerinde yaşadıkları zorlukların veya tekrarlayan depreş-me süreçlerinin ayrıntılı olarak tanımlanabilmesi alkol madde bağımlılığında tedavi stratejilerinin belirlenmesi ve sonraki depreşme süreçlerinin önlenmesi konusunda bağımlılık alanında çalışan klinisyenlere yol gösterici olacaktır.Anahtar sözcükler: Alkol ve madde bağımlılığı, remisyon, depreşme. AbstractAlcohol and substance addiction is a chronic disease and continues throughout individual's life once after addiction develops. Therefore its natural course is characterized by remissions and relapses. In addiction, relapse periods can be followed by remission periods and individuals encounter with negative effects of alcohol and substances in these relapse periods. Many factors have been defined to determine the risk of relapse up to the date. These factors can be situational or personal and they also have physiological bases. Interaction of these factors with each other is critical in terms of relapse. Relapse is a quite well studied area in the literature, in order to prevent the individuals from restarting alcohol and substance use again. Defining the challenges of addicted patients in remission periods and recurrent periods of relapse in detail will guide clinicians to determine treatment strategies in addiction and to prevent subsequent relapse periods.

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“…Esta resultaría de la interacción disfuncional de mecanismos serotoninérgicos, noradrenérgicos, gabérgicos y glutaminérgicos, estando relacionado el "reinforcement" o refuerzo primario con mecanismos dopaminérgicos y endorfínicos (110) . En consonancia con este modelo se han realizado estudios con antagonistas serotoninérgicos como ritanserina (111) ; antagonistas serotoninérgicos como buspirona (112,113,114) ; inhibidores de la recaptación de serotonina como fluvoxamina, fluoxetina, citalopram, zimelidina (115) ; sustancias dopaminérgi-cas como lisuride y tiapride (116) y, actualmente, se está estudiando la efectividad de flupentixol; antagonistas opiáceos como naltrexona (117,118) ; finalmente, sustancias antiglutaminérgicas como el acamprosato (119) . Mientras que los psicofármacos clásicos parecen ser efectivos en pacientes que presentan comorbilidad psiquiátrica, los resultados clínicos de la incorporación de sustancias anti-craving resultan dispares según qué grupo de pacientes con enfermedad alcohólica sea tratado.…”

Section: Medidas Terapéuticas Y Preventivas Tras El Tratamiento De Deunclassified

Estrategias en el tratamiento de desintoxicación alcohólica

Stauber¹

2003

Adicciones

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Antecedentes: El alcoholismo es uno de los problemas más graves con los que se enfrentan los sistemas de salud, tanto por el alto grado de morbilidad como por el índice de discapacidad y por las complicaciones médicas y psicosociales. La fase de desintoxicación supone la piedra angular en el tratamiento del paciente alcohólico.Métodos: Partimos de una revisión bibliográfica crítica del TDA y de una discusión teórica de las dimensiones que ha de atender un tratamiento eficaz.Resultados: Proponemos una secuencia de fases con características propias ( proceso diagnóstico y primeras medidas, decisiones médicas y psicoterápicas, coordinación multiprofesional del tratamiento, planificación del alta y seguimiento) y discutimos un conjunto de técnicas adaptadas a cada fase del tratamiento (arsenal farmacológico, estandarización de la exploración, trabajo de motivación, prevención secundaria). Proponemos un protocolo de tratamiento escalonado para los diferentes cuadros en orden a su gravedad; éste incluye fármacos eficaces (clometiazol, diazepam, tiapride, clonidina, carbamacepina, haloperidol, disulfiram, acamprosato y naltrexona) así como técnicas psicoterápicas (terapia grupal de confrontación constructiva, análisis de los mecanismos de defensa patológicos, self-management guiado por una reorientación de valores y por técnicas de modificación de conducta).Conclusión: El TDA tiene una dimensión fundamentalmente médica pero su éxito depende de un plan terapéutico multidimensional, pluriprofesional y personalizado que incluya un trabajo de motivación a la abstinencia así como una profilaxis de recaída. SUMMARYBackground: Due to high morbidity as well as severe medical and psychosocial consequences, alcoholism is one of our society's most serious health and social problems. Inpatient detoxification is probably the decisive phase in the whole treatment strategy. Method:We review the related literature and discuss the relevant dimensions of alcohol-withdrawal syndrome treatment strategies.Results: Our discussion is based on an incremental treatment program with specified characteristics at each stage. The stages include: diagnostic process, first measures after admission, medical and psychotherapeutic issues, treatment coordination, and finally, discharge and follow-up planning. We advocate appropriate measures at each stage (pharmacology, examination guide, motivation program, relapse prevention). After reviewing the most prevalent pharmaceutical treatments for alcohol withdrawal, we outline recommended treatments according to the degree of withdrawal, from mild symptoms to delirium tremens. Some drugs were effective, such as: clomethiazole, haloperidol, carbamazepine, tiapride, diazepam, clonidine, disulfiram, acamprosate and naltrexone. There were also effective psychotherapeutic approaches (group psychotherapy with confrontation techniques, defence-mechanism analysis, selfmanagement led by value reorientation and behaviour therapy). Conclusion:The treatment of alcohol-withdrawal syndrome entails a substantial medical ...

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Buspirone Treatment of Anxious Alcoholics

Abstract: Buspirone appears to have a useful role in the treatment of anxious alcoholics. Further research is needed to clarify which patient characteristics and concomitant treatments result in optimal response to buspirone therapy.

Cited by 229 publications

References 53 publications

Medication in the treatment of alcohol dependence

Medication in the treatment of alcohol dependence

Remission and Relapse in Alcohol and Substance Addiction

Estrategias en el tratamiento de desintoxicación alcohólica

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