C(-260)T Polymorphism in CD14 Receptor Gene of Egyptians with Acute Myocardial Infarction

Hossni, Nancy Mahmoud; Rahman, Mohamed F. Abdel; Shehata, Mohamed; Shaban, Gamal M.

doi:10.2174/1389201019666180605125803

Cited by 4 publications

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“…Inflammation is one of the most important risk factors in the pathogenesis of ACS. Variations in multiple genes involved in inflammation, and previous studies showed that there were close relationships between PPARα, interleukin 18 (IL-18), IL-1β, SIRT2, and CD14 receptor and incidence of acute myocardial infarction [24][25][26][27] . In the present study, we found the polymorphism (rs755622) of MIF gene was significantly associated with the risk of ACS in Chinese Han population.…”

Section: Discussionmentioning

confidence: 98%

MIF gene rs755622 polymorphism positively associated with acute coronary syndrome in Chinese Han population: case–control study

Luo

Wang

et al. 2020

Sci Rep

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Macrophage migration inhibitory factor (MIF) has been recognized as a major player in the pathogenesis of atherosclerosis. This study determined the association between polymorphisms of MIF gene and acute coronary syndrome (ACS). The polymorphism of MIF gene (rs755622, rs1007888 and rs2096525) was analyzed in 1153 healthy controls and 699 ACS cases in Chinese Han population. Plasma MIF level was also measured in part of ACS patients (139/19.9%) and healthy controls (129/11.2%) randomly. Most participants including healthy controls and ACS patients carried rs755622 GG (63.1% vs. 56.7%) and CG genotypes (33.1% vs. 38.9%) and G allele of rs755622 (79.6% vs. 76.1%, respectively), while CC genotype (3.8% vs. 4.4%) and C allele (20.4% vs. 23.9%) carriers were the lowest. Multivariate logistic regression analysis showed that carriers with rs755622 C allele had a higher risk of ACS compared to other genotypes (AOR = 1.278, 95% CI: 1.042-1.567). In addition, CC genotype carriers had the highest plasma levels of MIF than other genotype carriers. The MIF level in ACS patients with CC genotype was significantly higher than ACS patients carrying GG genotype and healthy controls carrying 3 different genotypes of MIF gene rs755622. Our findings indicate that MIF gene rs755622 variant C allele is associated with increased risk of ACS. Identification of this MIF gene polymorphism may help for predicting the risk of ACS. Coronary artery disease (CAD) is the leading cause of mortality worldwide, accounting for about 30% of deaths globally in 2012 and approximately 70% of deaths in developing countries 1. Acute coronary syndrome (ACS) is an urgent condition of CAD due to a rupture of the atherosclerotic plaque in coronary arteries. The complexity of CAD pathogenesis poses significant challenges to decision making for effective interventions. Use of multi-marker algorithms including biological markers and genetic markers will improve prediction of CAD risk in clinic 2. Inflammation plays critical roles in CAD and participates pivotally in almost every stage of atherosclerosis including initiation, progression and destabilization of plaque and myocardial infarction 3. MIF is produced by different cell types such as immune cells (monocytes, macrophages and lymphocytes) and endocrine, endothelial and epithelial cells 4. It has been proved that MIF plays an essential role in a variety of acute and chronic inflammatory disorders 5,6 as well as in cancer 7,8. Previous studies have also revealed a critical role of MIF in atherosclerosis 9,10 , therefore, MIF is very likely associated with the risk of ACS. The human MIF gene locates at chromosome region 22q11.2 comprising approximately 800 nucleotides and containing 3 exons and 2 introns 11. At least five single nucleotide polymorphisms (SNPs) in the human MIF gene locating at-173G/C (rs755622), +254 (rs2096525), +656 (rs2070766), 3.8 kb 3′ of the translation termination

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Section: Discussionmentioning

confidence: 98%

MIF gene rs755622 polymorphism positively associated with acute coronary syndrome in Chinese Han population: case–control study

Luo

Wang

et al. 2020

Sci Rep

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“…After the assessment of eligibility using the full‐text, 19 articles were excluded. Following this procedure, we finally identified 14 relevant case–control studies (Haberbosch et al, ; Hashad et al, ; Hohda et al, ; Hubacek et al, ; Koch et al, ; Liu, Liu, & Wei, ; Longobardo et al, ; Lorenzova et al, ; Morange et al, ; Nauck et al, ; Sediri et al, ; Shimada et al, ; Unkelbach et al, ; Zee, Lindpaintner, Struk, Hennekens, & Ridker, ) containing 18 data sets. The study performed by Koch et al () contains two sub‐studies which involved MI and AMI.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 18 data sets included, 14 were recorded among Caucasians, three among Asians, and only one among Africans. In only one study were the controls recruited from the common population (Hubacek et al, ) and in one study the genotype frequency distributions in the control groups deviated from the HWE (Hashad et al, ). It is well established that deviations in HWE deviations, especially for a control group, are a strong indicator of technical errors during genotyping (Hosking et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…A common single nucleotide polymorphism in the CD14 promoter (rs2569190) has been found to be related to a decreased affinity for Sp1 protein binding (LeVan et al, ). More recently, many studies have reported that the −260C>T change (sometimes referred to as position −159) (Raza et al, ) in CD14 is related to a higher risk of MI (Hohda et al, ; Hubacek et al, ; Shimada et al, ; Unkelbach et al, ); however, other studies have failed to confirm such an association between this polymorphism and risk of MI (Haberbosch et al, ; Hashad et al, ; Koch, Kastrati, Mehilli, von Beckerath, & Schomig, ; Longobardo et al, ; Lorenzova et al, ; Sediri et al, ). Therefore, a meta‐analysis was performed to conclude a more comprehensive estimation of the relationship between CD14−260C>T polymorphism and MI susceptibility.…”

Section: Introductionmentioning

confidence: 99%

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Association between the CD14−260C>T gene polymorphism and susceptibility to myocardial infarction: Evidence from case−control studies

Zhao

Xie

et al. 2019

Int J Immunogenetics

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Numerous published studies have investigated the relationship between the CD14−260C>T (rs2569190) polymorphism and the risk of myocardial infarction (MI). However, the results are still conflicting and inconclusive. Potentially eligible published articles were searched in four databases including PubMed, Web of Science, EMBASE and Chinese Biomedical Database (CBM). The odds ratio (OR) with its 95% confidence interval (CI) was used to estimate the strength of the associations. Thirteen papers including 17 case–control studies were included, reporting a total of 6,443 MI patients and 6,315 controls. A significant increase in overall MI susceptibility was identified in the homozygote model. In the subgroup analysis, with respect to the type of MI, a significantly increasing acute MI susceptibility was found in the homozygote model. In the subgroup analysis for ethnicity, a significant increased susceptibility was found in Asian populations in allele, homozygote, recessive and dominant models. However, no significant association was found among Caucasian populations. In conclusion, there may be a moderate association between the CD14−260C>T polymorphism and acute MI susceptibility. This association may be different between ethnicities with the CD14−260C>T polymorphism being a risk factor for myocardial infarction in Asian populations.

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Associations of CD14 variants with the triglyceride levels and risk of myocardial infarction in an Eastern Chinese Han population

Pan

Ding

2021

International Immunopharmacology

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C(-260)T Polymorphism in CD14 Receptor Gene of Egyptians with Acute Myocardial Infarction

Abstract: CD14 C-(260)T polymorphism is not associated with incidence of acute myocardial infarction in Egyptians who showed elevated serum CD14 levels in comparison to healthy individuals.

Cited by 4 publications

References 0 publications

MIF gene rs755622 polymorphism positively associated with acute coronary syndrome in Chinese Han population: case–control study

MIF gene rs755622 polymorphism positively associated with acute coronary syndrome in Chinese Han population: case–control study

Association between the CD14−260C>T gene polymorphism and susceptibility to myocardial infarction: Evidence from case−control studies

Associations of CD14 variants with the triglyceride levels and risk of myocardial infarction in an Eastern Chinese Han population

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