C-reactive protein and cardiovascular risk in bipolar disorder patients: A systematic review

Marshe, Victoria S.; Pira, Shamira; Mantere, Outi; Bosche, Bert; Looper, Karl; Herrmann, Nathan; Müller, Daniel J.; Rej, Soham

doi:10.1016/j.pnpbp.2017.07.026

Cited by 28 publications

(15 citation statements)

References 81 publications

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“…10,64,79 Twin studies and molecular genetic studies have revealed relatively modest genetic correlations between cardio-metabolic abnormalities, CHD and mental disorders. 9,20,63 These observations suggest potential pleiotropic effects of a shared gene locus that is associated with mental disorders and cardiometabolic diseases. 10…”

Section: Genetic Mechanismsmentioning

confidence: 94%

“…These physiological processes are all involved in the development and progression of CHD. 9,11,12,17,19,20,44,47,52,57,[59][60][61]63,64 T r a n s l a t i o n a l r e s e a r c h…”

Section: Biological Mechanismsmentioning

confidence: 99%

“…The use of antipsychotic medication and, to a lesser extent, antidepressants and mood stabilizers, may increase the risk of CHD. 14,39,63,77 In addition to obesity and other cardio-metabolic-related mechanisms, a direct effect of antipsychotics on cardiovascular risk may exist. For example, ANS dysfunction triggered by schizophrenia may be exacerbated by antipsychotic treatment through blockade of peripheral dopamine receptors, increasing sympathetic activity.…”

Section: Medicationmentioning

confidence: 99%

“…59 In individuals with BPD psychological factors such as childhood trauma, stress, and some personality features have been hypothesized to contribute to both CHD in BPD patients and BPD itself. 63…”

Section: Psychological Mechanismsmentioning

confidence: 99%

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The intriguing relationship between coronary heart disease and mental disorders

Hert

Vancampfort

2018

Dialogues in Clinical Neuroscience

366

159

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Coronary heart disease (CHD) and mental illness are among the leading causes of morbidity and mortality worldwide. Decades of research has revealed several, and sometimes surprising, links between CHD and mental illness, and has even suggested that both may actually cause one another. However, the precise nature of these links has not yet been clearly established. The goal of this paper, therefore, is to comprehensively review and discuss the state-of-the-art nature of the epidemiological and pathophysiological aspects of the bidirectional links between mental illness and CHD. This review demonstrates that there exists a large body of epidemiological prospective data showing that people with severe mental illness, including schizophrenia, bipolar disorder, and major depressive disorder, as a group, have an increased risk of developing CHD, compared with controls [adjusted hazard ratio (adjHR)=1.54; 95% CI: 1.30-1.82, P<0.0001]. Anxiety symptoms or disorders (Relative Risk (RR)=1.41, 95% CI: 1.23-1.61, P<0.0001), as well as experiences of persistent or intense stress or posttraumatic stress disorder (PTSD) (adjHR=1.27, 95% CI: 1.08-1.49), although to a lesser degree, may also be independently associated with an increased risk of developing CHD. On the other hand, research also indicates that these symptoms/mental diseases are common in patients with CHD and may be associated with a substantial increase in cardiovascular morbidity and mortality. Finally, mental diseases and CHD appear to have a shared etiology, including biological, behavioral, psychological, and genetic mechanisms.

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Section: Genetic Mechanismsmentioning

confidence: 94%

“…These physiological processes are all involved in the development and progression of CHD. 9,11,12,17,19,20,44,47,52,57,[59][60][61]63,64 T r a n s l a t i o n a l r e s e a r c h…”

Section: Biological Mechanismsmentioning

confidence: 99%

Section: Medicationmentioning

confidence: 99%

Section: Psychological Mechanismsmentioning

confidence: 99%

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The intriguing relationship between coronary heart disease and mental disorders

Hert

Vancampfort

2018

Dialogues in Clinical Neuroscience

366

159

View full text Add to dashboard Cite

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“…Genel nüfusta kanda artmış seviyelerinin KVH riski oluşturduğu öne sürülmüştür (13). Ciddi mental bozukluklarda CRP'de artış olduğu gösterilmiştir (14,15,16). Bu bozukluklarda KVH risk faktörlerinden bağımsız olarak da inflamasyon belirteçlerinde düzensizlik olabildiği bulunmuştur (17).…”

Section: Introductionunclassified

Assessment of cardiovascular risk for serious mental disorders (tur)

Çınar¹,

Dürmüş²

2019

J Clin Psy

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Objective: Incidence and prevalence of cardiovascular diseases in patients with severe mental disorders are higher than the general population. It was aimed to calculate the 10 year cardiovascular disease risk by using Framingham risk scoring (FRS) and investigate the relationship between this score and C-reactive protein in psychiatric inpatients of a university hospital. Method: Inpatients with the diagnosis of major depression, bipolar disorders and psychotic disorders in six months time were included in the study.Participants were assessed based on their gender, age, body mass index, waist circumference, FRS, and CRP levels. Results: The calculated 10 year cardiovascular disease development risk did not differ between the diagnosis (p=0,39), but found to be significantly higher in males than females (p=0,002). FRS levels showed positive correlations with male gender (p=0,002), age (p=0,000), waist circumference (p=0,001), and body mass index (p=0,001). Discussion: We have to evaluate coesisting somatic diseases of psychiatric patients as well as behavioral and psychological problems. Using FRS, evaluating body mass index and waist circumference could help us predict the risky population and we could consider our drug treatment choices accordingly.

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