Ca2+ responses to ATP via purinoceptors in the early embryonic chick retina.

Sugioka, Miho; Fukuda, Yutaka; Yamashita, Mitsuo

doi:10.1113/jphysiol.1996.sp021428

Cited by 72 publications

(50 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Purinergic signaling, mainly mediated by ATP, has been speculated to regulate adult neurogenesis because it is important for the proliferation of various cell types during development (Zimmerman, 2006), including cortical radial glial cells (Weissman et al, 2004), retinal progenitors (Sugioka et al, 1996;Pearson et al, 2002;Nunes et al, 2007), and olfactory epithelium progenitors (Hassenklöver et al, 2009) in the CNS. Purinergic signaling receptors and nucleotide breakdown enzymes such as ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2) and tissue-nonspecific alkaline phosphatase are also present in the SVZ (Braun et al, 2003;Langer et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Purinergic Signaling Promotes Proliferation of Adult Mouse Subventricular Zone Cells

Suyama¹,

Sunabori²,

Kanki³

et al. 2012

Journal of Neuroscience

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Purinergic Signaling Promotes Proliferation of Adult Mouse Subventricular Zone Cells

Suyama¹,

Sunabori²,

Kanki³

et al. 2012

Journal of Neuroscience

View full text Add to dashboard Cite

“…Suramin blocked the wave, but pyridoxalphosphate-6-azophenyl-2 0 ,4 0 -disulphonic acid (PPADS) did not have a consistent antagonist action. A study of embryonic chick neural retina [151] (Fig. 8) has shown that the ATP-induced rise in intercellular Ca 2?…”

Section: Retinamentioning

confidence: 99%

Purinergic signaling in embryonic and stem cell development

Burnstock

Ulrich

2011

Cell. Mol. Life Sci.

112

View full text Add to dashboard Cite

Nucleotides are of crucial importance as carriers of energy in all organisms. However, the concept that in addition to their intracellular roles, nucleotides act as extracellular ligands specifically on receptors of the plasma membrane took longer to be accepted. Purinergic signaling exerted by purines and pyrimidines, principally ATP and adenosine, occurs throughout embryologic development in a wide variety of organisms, including amphibians, birds, and mammals. Cellular signaling, mediated by ATP, is present in development at very early stages, e.g., gastrulation of Xenopus and germ layer definition of chick embryo cells. Purinergic receptor expression and functions have been studied in the development of many organs, including the heart, eye, skeletal muscle and the nervous system. In vitro studies with stem cells revealed that purinergic receptors are involved in the processes of proliferation, differentiation, and phenotype determination of differentiated cells. Thus, nucleotides are able to induce various intracellular signaling pathways via crosstalk with other bioactive molecules acting on growth factor and neurotransmitter receptors. Since normal development is disturbed by dysfunction of purinergic signaling in animal models, further studies are needed to elucidate the functions of purinoceptor subtypes in developmental processes.

show abstract

“…This suggests that endogenous noradrenaline, acting via ␣-adrenergic receptors, is part of the mechanism controlling neuronal differentiation in the central nervous system. Very little is known about the roles of extracellular ATP in early embryonic development, but this molecule has been shown to cause an increase in intracellular Ca 2ϩ (Ca 2ϩ i ) 2 concentration in a number of embryonic cell types, including dissociated cells from early chick embryos (18), early embryonic chick otocyst (19) and retina (20), cultured astrocytes from embryonic rat spinal cord (21), cultured neurons from embryonic rat brain (22), myotubes cultured from embryonic chick (23), and a murine myoblast cell line (24). Increases in Ca 2ϩ i are known to regulate cell proliferation, migration, and differentiation (15,25), all important processes during embryonic development.…”

mentioning

confidence: 99%

“…Increases in Ca 2ϩ i are known to regulate cell proliferation, migration, and differentiation (15,25), all important processes during embryonic development. The P2 receptor(s) responsible for most of these ATP-activated developmental signals have not been identified, and none have been cloned, although the response of embryonic chick retina is thought to be mediated by a P2Y receptor responsive to UTP (20).…”

mentioning

confidence: 99%

Early Expression of a Novel Nucleotide Receptor in the Neural Plate of Xenopus Embryos

Bogdanov

Dale

King

et al. 1997

Journal of Biological Chemistry

117

View full text Add to dashboard Cite

Extracellular ATP functions as a neurotransmitter and neuromodulator in the adult nervous system, and a signaling molecule in non-neural tissue, acting either via ligand-gated ion channels (P2X) or G-protein-coupled receptors (P2Y Receptors for extracellular nucleotides (P2 receptors) are found on the cell surface of all higher animal tissues, where they regulate a broad range of physiological processes (1). These receptors have been categorized into two major groups (P2X and P2Y), based on their pharmacological and electrophysiological properties, as well as their molecular structure (2, 3). P2X receptors are members of the ligand-gated ion channel superfamily, while P2Y receptors have seven transmembrane domains and belong to the G-protein-coupled-receptor superfamily. To date, seven P2X (P2X 1-7 ) and seven P2Y (P2Y 1-7 ) receptors have been cloned from mammalian and avian species (3). Different P2Y receptors show preferential selectivity for purine and pyrimidine nucleotides; whereas P2Y 1 is responsive to ATP but not UTP (4), P2Y 2 is equally responsive to both ATP and UTP (5) and P2Y 4 is responsive to UTP and much less to ATP (6, 7). p2y3 1 and P2Y 6 are selective for nucleoside diphosphates (8, 9), while p2y5 and P2Y 7 bind ATP with a greater avidity than UTP (10, 11). In most cell types P2Y receptor activation results in the hydrolysis of phosphatidylinositol (4,5)-bisphosphate to the Ca 2ϩ

show abstract

Ca2+ responses to ATP via purinoceptors in the early embryonic chick retina.

Cited by 72 publications

References 38 publications

Purinergic Signaling Promotes Proliferation of Adult Mouse Subventricular Zone Cells

Purinergic Signaling Promotes Proliferation of Adult Mouse Subventricular Zone Cells

Purinergic signaling in embryonic and stem cell development

Early Expression of a Novel Nucleotide Receptor in the Neural Plate of Xenopus Embryos

Contact Info

Product

Resources

About