Cadmium Chloride Toxicity Revisited: Effect on Certain Andrological, Endocrinological and Biochemical Parameters of Adult Male Rabbits

Sajjad, S.; Malik, Hira; Farooq, Umer; Rashid, Fouzia; Nasim, Hayati Roudbari; Tariq, Saeed; Rehman, Shafiqur

doi:10.33549/physiolres.932641

Cited by 13 publications

(4 citation statements)

References 27 publications

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“…The present study demonstrated that four weeks of CdCl 2 exposure (5 mg/kg BW) in the absence of EBN supplement adversely affected body weight and OBWR; Cd at a lower dose has shown an adverse effect on the body weight of female rats, as demonstrated by previous studies (Nampoothiri et al, 2007;Nna et al, 2017;Samuel et al, 2011). A study conducted by Sajjad et al (2014) had found a relationship between body weight loss and concentration of Cd in hypothalamus and pituitary of Cd exposed animals. The loss in body weight due to Cd exposure may be associated with the formation of free radicals resulting in oxidative stress (Patra et al, 2011).…”

Section: Results and Discussion Body And Ovary Weightsupporting

confidence: 79%

Protective Effect of Edible Bird’s Nest on Ovaries of Cycling Female Rats Subjected to Cadmium Toxicity

Quddus¹,

Yimer²,

Jesse³

et al. 2021

JAHP

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| Cadmium (Cd), a toxic heavy metal, is often associated with the reproductive disorders of mammals. The edible bird's nest (EBN) is a naturally occurring food product made from the saliva of swiftlet birds (Aerodramus fuciphagus & Aerodramus maximus) in the form of a nest, and it has been consumed as healthy food or tonic for decades. This research aimed to study the possible protective effects of EBN against Cd toxicity in ovaries of Sprague Dawley rats. Thirty (30) female Sprague Dawley rats were assigned into five groups as follows: group 1-Negative control (NC) received distilled water; group 2-positive control (PC) administered with CdCl 2 , 5mg/kg BW; while groups EBN 1, EBN 2, and EBN 3 received CdCl 2 (5mg/kg BW) concurrently with graded concentrations of 60, 90 and 120 mg/kg BW of EBN, respectively. After four weeks of treatment, rats were euthanized to collect ovaries for histopathological studies using hematoxylin and eosin (H&E) stain. Expressions of vascular endothelial growth factor (VEGF) were analyzed through immunohistochemistry, and levels of superoxidase dismutase (SOD) were assessed using a SOD assay kit. Oral administration of CdCl 2 without EBN supplement resulted in significantly decreased (p<0.05) immunohistochemical expressions of VEGF in ovarian tissue and a decrease (p<0.05) in the activity of SOD. Moreover, ovarian histopathological changes, including follicular cysts and a significant increase (p<0.05) in the number of atretic follicles, while a decrease in the number of growing follicles was noted in Cd only treated group. Animals treated with CdCl 2 and EBN at three different dosages resulted in significantly increased (p<0.05) expressions of VEGF in ovarian tissues, low degenerative changes with normal histomorphology as well as significantly increased (p<0.05) SOD activity as compared to the PC group. Overall, the findings revealed that oral exposure to Cd at a dose rate of 5 mg/kg BW resulted in significant alterations in ovaries, as evidenced by a lower degree of VEGF expression along with reduced antioxidant activity and histomorphological changes. Meanwhile, EBN proved to exhibit a significant protective role against Cd toxicity in ovaries, possibly through its antioxidant effect.

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Section: Results and Discussion Body And Ovary Weightsupporting

confidence: 79%

Protective Effect of Edible Bird’s Nest on Ovaries of Cycling Female Rats Subjected to Cadmium Toxicity

Quddus¹,

Yimer²,

Jesse³

et al. 2021

JAHP

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“…(1) it is noticed that the treatment of rats with cadmium chloride led to a significant increase (P≤ 0.05) in the level of ALT, AST and ALP compared to the control group. These results agreed with the results of Mohamed et al [20] , And Sajjad et al [21] . who found that levels of liver enzymes increased significantly in the group of animals treated with cadmium chloride due to the occurrence of hepatocyte toxicity.…”

Section: Image (6) Section Of the Rat Liver Of The Group Treated With Cadmium Chloride And Mustard Seed Extract Showing The Central Vein supporting

confidence: 93%

Toxicity of Cadmium Chloride on White Rats Liver and the Protective Role of Brassica Nigra Seed Extract

Asaad¹,

Razooqi²,

Mustafa³

2021

Indian Journal of Forensic Medicine & Toxicology

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The study designed for the toxic role of cadmium chloride on the liver of mice from both a physiological and histological aspects. The animals were treated with a dose of 5 mg/kg of body weight for 30 days. And the protective role of Brassica nigra seed extract against cadmium chloride toxicity. This pilot study was conducted on 20 adult white rats divided into 4 equivalent groups including the control group: Animals in this group received a dosed of distilled water for 30 days. The placebo group was treated with cadmium chloride at a dose of 5 mg/kg of body weight for 30 days and returned as an infected control group. While in the third group, animals treated with cadmium chloride were dosed with Brassica nigra seed extract at a dose of 200 mg/kg of body weight for 30 days. The fourth group was dosed with Brassica nigra seed extract at a dose of 200 mg/kg of body weight for 30 days. After 30 days, liver enzymes including aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were measured by spectrophotometric method. In addition to making tissue sections of the liver. The treatment of rats led to a significant increase (P≤0.05) in liver enzymes compared with the control group. It also led to histopathology in the liver tissue, while the Brassica nigra seed extract acted as a protective role against the toxicity of cadmium chloride.

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“…Testicular tissue is particularly susceptible to cadmium-induced damage. Cd causes degeneration of rats' epididymis, seminal vesicles and spermatozoa (Sajjad et al, 2014).…”

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confidence: 98%

“…Testicular tissue is particularly susceptible to cadmium-induced damage. Cd causes degeneration of rats' epididymis, seminal vesicles and spermatozoa (Sajjad et al, 2014).Cd, other heavy metals and oestrogenic-based compounds may explain the recent deterioration in male fertility in industrialised regions in the form of sperm count and testicular function reduction. This may involve the fact that Cd disrupts endocrine control of testicular tissue and induces oxidative damage (Siu et al, 2009).Cd exposure is linked with the generation of free radicals in acute toxicity and reactive oxygen species (ROS) in chronic toxicity.…”

mentioning

confidence: 99%

Caffeine versus antioxidant combination (Antox) and their role in modifying cadmium‐induced testicular injury in adult male albino rats

Labib

Galal

2020

Andrologia

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The unfavourable outcome of cadmium (Cd) on male fertility, sex hormones' production and sperm criteria have been reported in literature (Medina et al., 2017). Testicular tissue is particularly susceptible to cadmium-induced damage. Cd causes degeneration of rats' epididymis, seminal vesicles and spermatozoa (Sajjad et al., 2014). Cd, other heavy metals and oestrogenic-based compounds may explain the recent deterioration in male fertility in industrialised regions in the form of sperm count and testicular function reduction. This may involve the fact that Cd disrupts endocrine control of testicular tissue and induces oxidative damage (Siu et al., 2009). Cd exposure is linked with the generation of free radicals in acute toxicity and reactive oxygen species (ROS) in chronic toxicity. Cdgenerated superoxide anion, hydrogen peroxide and hydroxyl radicals have been reported and are usually associated with redox reactions and ROS-related genetic alterations. It is, therefore, stated that oxidative damage plays an integral part in cadmium toxicity (Liu et al., 2009). In rats subjected to prenatal Cd exposure, plasma testosterone concentrations are drastically lowered and expression of

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Cadmium Chloride Toxicity Revisited: Effect on Certain Andrological, Endocrinological and Biochemical Parameters of Adult Male Rabbits

Cited by 13 publications

References 27 publications

Protective Effect of Edible Bird’s Nest on Ovaries of Cycling Female Rats Subjected to Cadmium Toxicity

Protective Effect of Edible Bird’s Nest on Ovaries of Cycling Female Rats Subjected to Cadmium Toxicity

Toxicity of Cadmium Chloride on White Rats Liver and the Protective Role of Brassica Nigra Seed Extract

Caffeine versus antioxidant combination (Antox) and their role in modifying cadmium‐induced testicular injury in adult male albino rats

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