Cadmium, Gene Regulation, and Cellular Signalling in Mammalian Cells

Beyersmann, Detmar; Hechtenberg, Stefan

doi:10.1006/taap.1997.8125

Cited by 499 publications

(255 citation statements)

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“…A major shared feature of the rodent and human renal systems was clearly demonstrated in the capacity for Cd2+ exposure to induce a large increase in MT protein within the renal proximal tubule. In general, it has been shown in numerous rodent studies that Cd2+ is a potent inducer of the hepatic and renal MT-1 and MT-2 genes, which leads to large increases in MT protein accumulation (1,(28)(29)(30) (36)(37)(38). This increase occurs particularly in the outer cortex and outer stripe of the outer medulla and is presumably due to increased transcription of the MT genes (3,9).…”

Section: Discussionmentioning

confidence: 99%

Exposure of Human Proximal Tubule Cells to Cd 2+ ,Zn 2+ , and Cu 2+ Induces Metallothionein Protein Accumulation but not Metallothionein Isoform 2 mRNA

Garrett¹,

Somji²,

Todd³

et al. 1998

Environmental Health Perspectives

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The oranization of the human meallothionein (MT) gene family is more complex than the commonly used mouse and rat models. The human MTs are encoded by a family of genes consisting of 10 functional and 7 nonfunctional MT isoforms. One objective of this study was to determine if the accumulation of MT protein in culue of human proximal tubule (HPI) cells exosed to metals is similar to that expected from the knowledge base obtained from rodent models. To accomplish this objective, HIT cells were exposed to both lethal and sublethal concentrations of Cd2, Zn2*, Cu2+ Ag2t Hg2, and Pb2+ and MT ptein l were determinedThe results were in general ment th animal modal suiehre were some : exceptions, mainly in areas w the model database was l Inlr aeement with animal models, Cd2, 7.2, a C2 were demonstted t b pot idcs of MT protein accumulation. In contrast to aity in MT protein expression, w eo evidence that the human renal MT-2 gene.hs a unique pattern of rlation cmred to both animal models and human-derived ceil cultures.. In the present study, we determined that MT-2A mRNA was not induced by exposure of HPT cells to Cd2 or the other metals, a finding in contrat to studies in both animal models and other human cel culture systems in which a high level ofMT-2 mRNA induction occurs upon eposure to Ct or Zn2+. While MT protein pression may be similar betwee humans and animal modals, this finding provides initial evidence that regulation of the genes underlying MT protein expression may be dierent beteen species.

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Section: Discussionmentioning

confidence: 99%

Exposure of Human Proximal Tubule Cells to Cd 2+ ,Zn 2+ , and Cu 2+ Induces Metallothionein Protein Accumulation but not Metallothionein Isoform 2 mRNA

Garrett¹,

Somji²,

Todd³

et al. 1998

Environmental Health Perspectives

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“…A number of recent reports have provided increasing information on selected aspects of Cd-dependent regulation of gene expression and signal transduction pathways. Cd ion can enter and accumulate into cells probably through voltage-sensitive calcium channels of the plasma membrane [3].…”

Section: Introductionmentioning

confidence: 99%

Effects of cadmium chloride on some mitochondria-related activity and gene expression of human MDA-MB231 breast tumor cells

Cannino

Ferruggia

Luparello

et al. 2008

Journal of Inorganic Biochemistry

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“…Cadmium has been shown to modulate second messenger metabolism, protein kinase and phosphatase activities, and transcription factor binding to DNA (14). Cadmium (15) and zinc (16,17) evoked the mobilization of Ca 2+ through the formation of inositol trisphosphate.…”

mentioning

confidence: 99%