Cadmium in Human Diseases: It’s More than Just a Mere Metal

Fatima, Ghizal; Raza, Ammar Mehdi; Hadi, Najah R; Nigam, Nitu; Mahdi, Abbas Ali

doi:10.1007/s12291-019-00839-8

Cited by 174 publications

(69 citation statements)

References 54 publications

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“…Cadmium (Cd) is one of them [3,6]. The growing industrial use of this element in the last decades has resulted in the contamination of the natural environment with this xenobiotic, and unavoidable human exposure to it during a lifetime [7][8][9]. Nowadays, this heavy metal belongs to the main environmental contaminants in economically developed countries [3,7,9].…”

Section: Introductionmentioning

confidence: 99%

“…Cadmium is a pollutant of air, water, and soil, as thus it is present in food, which is the main source of the general population's exposure to this heavy metal [9][10][11]. Furthermore, an additional source of intoxication with this xenobiotic is tobacco smoking [8,12]. Cadmium concentrations in the blood and urine of habitual smokers are markedly higher than in non-smokers [8,12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, an additional source of intoxication with this xenobiotic is tobacco smoking [8,12]. Cadmium concentrations in the blood and urine of habitual smokers are markedly higher than in non-smokers [8,12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Because current environmental exposure to cadmium creates a threat to the health of the general population [3,8,10,11,13,[15][16][17][18] and the lifetime human exposure to this xenobiotic will increase [9][10][11], the attention of researchers in recent years has been focused on finding effective ways to prevent the unfavourable health effects of exposure to this heavy metal. Taking into account the strong pro-oxidative properties of cadmium and the involvement of oxidative stress in the mechanisms of its damaging impact on various organs and systems [3,5,14,[19][20][21][22][23], the greatest interest among the possible protective agents has been paid to natural products characterized by strong antioxidative properties, including polyphenol-rich ones [14,[24][25][26].…”

Section: Introductionmentioning

confidence: 99%

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Beneficial Impact of an Extract from the Berries of Aronia melanocarpa L. on the Oxidative-Reductive Status of the Submandibular Gland of Rats Exposed to Cadmium

Dąbrowski¹,

Onopiuk²,

Car

et al. 2020

Antioxidants

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Oxidative stress underlies the pathomechanisms of toxic action of cadmium (Cd), including its damaging impact on the oral cavity. This study investigated whether the administration of an extract from Aronia melanocarpa L. berries (AME), characterized by their strong antioxidative potential, may have a beneficial impact on the oxidative-reductive status of the submandibular gland in an experimental model of low-level and moderate human environmental exposure to cadmium. The main markers of the antioxidative status (glutathione reductase, superoxide dismutase, catalase, reduced glutathione, total antioxidative status (TAS)), total oxidative status (TOS), oxidative stress index (OSI = TOS/TAS), and lipid peroxides, as well as cadmium concentration, were evaluated in the submandibular gland tissue of female Wistar rats who received a 0.1% aqueous AME and/or a diet containing 0, 1, and 5 mg Cd/kg for 3 and 10 months. The treatment with cadmium decreased the activities of antioxidative enzymes (29%–74%), reduced glutathione concentration (45%–52%), and TAS and increased TOS, resulting in the development of oxidative stress and enhanced concentration of lipid peroxides in the submandibular gland. The administration of AME at both levels of exposure to cadmium offered significant protection against these actions of this xenobiotic. After the 10 month exposure to the 1 and 5 mg Cd/kg diet, TAS was decreased by 77% and 83%, respectively, TOS, OSI, and lipid peroxides concentration were increased by 50% and 52%, respectively, 11.8-fold and 14.4-fold, respectively, and 2.3-fold and 4.3-fold, respectively, whereas, in the case of the extract co-administration, the values of these parameters did not differ compared to the control group. The results indicate that the consumption of aronia products under exposure to cadmium may have a beneficial impact on the oxidative-reductive status of the submandibular gland and prevent oxidative stress development and enhanced lipid peroxidation in this salivary gland.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Beneficial Impact of an Extract from the Berries of Aronia melanocarpa L. on the Oxidative-Reductive Status of the Submandibular Gland of Rats Exposed to Cadmium

Dąbrowski¹,

Onopiuk²,

Car

et al. 2020

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Cadmium is a highly toxic heavy metal with a long biological half-life, easily accumulates in organisms, and is difficult to eliminate [1][2][3]. The International Agency for Research on Cancer (IARC) has defined cadmium as a human carcinogen that can lead to liver cancer, kidney cancer, and osteomalacia, and cadmium is a soil and water contaminant strictly controlled by all countries [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Ammonium Pyrrolidine Dithiocarbamate-Modified CdTe/CdS Quantum Dots as a Turn-on Fluorescent Sensor for Detection of Trace Cadmium Ions

Yin

Yang

Liu

2020

Sensors

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In this work, ammonium pyrrolidine dithiocarbamate (APDC) was used as a surface etchant to modify CdTe/CdS core-shell quantum dots (QDs). The APDC etchant combines with the cadmium ions (Cd2+) on the surface of the QDs, resulting in the formation of surface holes. The formation of these holes changes the QD surface structure, which leads to fluorescence quenching of the QDs. Newly added Cd2+ can selectively recognize and combine with these holes; thus, the fluorescence intensity of the QDs can be restored. The linear response of this turn-on fluorescent sensor was found to be 0–100 μg/L and 100–600 μg/L under the determined optimal conditions, and its limit of detection (LOD) for Cd2+ was 2.642 μg/L (23.5 nmol/L).

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A Robust Electrochemical Sensor Based on Butterfly‐shaped Silver Nanostructure for Concurrent Quantification of Heavy Metals in Water Samples

et al. 2022

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Heavy metals in drinking water have become a severe threat to human health. Detection of heavy metals has been achieved by electrochemical sensors that are modified with complex nanocomposites; however, reproducibility of these sensors is still a big challenge when applied in commercial settings. Here, a simple, very robust, and sensitive electrochemical sensor based on a screen‐printed carbon electrode modified with butterfly‐shaped silver nanostructure (AgNS/SPCE) has been developed for the concurrent determination of cadmium (II), lead (II), copper (II), and mercury (II) in water samples. The electrochemical behavior of the modified electrodes was investigated using cyclic voltammetry and differential pulse anodic stripping voltammetry. The AgNS/SPCE showed distinct peak potentials and a significant increase in the peak currents for all heavy metals, attributed to the high electrical conductivity and electrocatalytic activity of the synthesized butterfly‐shaped AgNS. Moreover, the excellent stability and sensitivity towards simultaneous quantification of heavy metals have been obtained with detection limits of 0.4 ppb, 2.5 ppb, 7.3 ppb, and 0.7 ppb for Cd (II), Pb (II), Cu (II), and Hg (II), respectively. Besides, the constructed sensor was successfully applied to simultaneously quantify target heavy metals in spiked water samples. Owing to excellent sensitivity, high robustness, affordability, and fast response, the presented electrochemical sensor could be incorporated into a portable and miniaturized potentiostat device, making it a promising method for on‐site water analysis.

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Cadmium in Human Diseases: It’s More than Just a Mere Metal

Cited by 174 publications

References 54 publications

Beneficial Impact of an Extract from the Berries of Aronia melanocarpa L. on the Oxidative-Reductive Status of the Submandibular Gland of Rats Exposed to Cadmium

Beneficial Impact of an Extract from the Berries of Aronia melanocarpa L. on the Oxidative-Reductive Status of the Submandibular Gland of Rats Exposed to Cadmium

Ammonium Pyrrolidine Dithiocarbamate-Modified CdTe/CdS Quantum Dots as a Turn-on Fluorescent Sensor for Detection of Trace Cadmium Ions

A Robust Electrochemical Sensor Based on Butterfly‐shaped Silver Nanostructure for Concurrent Quantification of Heavy Metals in Water Samples

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